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    Effects of letrozole on biochemical markers of bone and liver
    (Amer Assoc Clinical Chemistry, 2008) Yonden, Z.; Aydin, M.; Alcin, E.; Yilmaz, B.
    [Abstract Not Available]
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    Effects of letrozole on bone biomarkers and femur fracture in female rats
    (Servicio Publicaciones Universidad Navarra, 2009) Yonden, Z.; Aydin, M.; Alcin, E.; Kelestemur, M. H.; Kutlu, S.; Yilmaz, B.
    Z. YONDEN, M. AYDIN, E. ALCIN, M.H. KELESTEMUR, S. KUTLU and B. YILMAZ. Effects of letrozole on bone biomarkers and femur fracture in female rats. J Physiol Biochem, 65 (3), 267-276, 2009. We aimed to investigate the effects of the aromatase inhibitor letrozole on femur fracture and serum levels of alkaline phosphatase (ALP), calcium and phosphate in female rats. Intact 32 Sprague-Dawley female rats were divided into four groups (n=8): control, letrozole 0.2, letrozole 1 (treatment of 0.2 and 1 mg/kg for six weeks) and recovery (letrozole-treated 1 mg/kg for six weeks then allowed to recover for two weeks). Besides, 24 ovariectomized rats were divided into three groups (n=8): ovariectomized+control, ovariectomized+letrozole and ovariectomized+letrozole+ estradiol (10 mu g/rat). After experimental period, rats' femur bones were removed for biomechanical studies following decapitation. Serum ALP, calcium and phosphate were measured. Biomechanical values, ALP and phosphate significantly increased by letrozole in a dose-dependent manner (p<0.05) while calcium levels and net bone area decreased (p<0.05). Ultimate strength was positively correlated with ALP and phosphate and negatively correlated with calcium. The results indicate that letrozole may increase risk of bone fracture and affect bone biomarkers such as ALP, calcium and phosphate in both intact and ovariectomized rats.
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    Protective effects of caffeic acid phenethyl ester on iron-induced liver damage in rats
    (Springer, 2009) Oktar, S.; Yonden, Z.; Aydin, M.; Ilhan, S.; Alcin, E.; Ozturk, O. H.
    S. OKTAR, Z. YONDEN, M. AYDIN, S. ILHAN, E. ALCIN and O.H. OZTURK. Protective effects of caffeic acid phenethyl ester on iron-induced liver damage in rats. J Physiol Biochem, 65 (4), 339-344, 2009. Caffeic acid phenethyl ester (CAPE) is a natural product with potent anti-inflammatory, antitumor, and antioxidant activities, and attenuates inflammation and lipid peroxidation. The purpose of the present study was to investigate the effects of CAPE on iron-induced liver damage. Rats were divided into four groups and treated for 7 days with saline (control group), 10 mu mol kg CAPE/day s.c. (CAPE group), 50 mg iron-dextran/kg i.p. (IRON group) and CAPE and iron at the same time (IRON+CAPE group). Seven days later, rats were killed and the livers were excised for biochemical analysis. The administration of IRON alone resulted in higher myeloperoxidase (MPO) activity and lipid peroxidation than in the control and CAPE treatment prevented the increase in MPO activity and malondialdeyde (MDA) level. No differences were observed in all four groups with regards to superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities. Our results collectively suggest that CAPE may be an available agent to protect the liver from injury via inhibition of MPO activity.