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Öğe Effects of Desflurane and Isoflurane on Postanaesthetic Recovery Characteristics with Hepatic and Renal Functions in Dogs(Medwell Online, 2009) Altug, M. E.; Gonenci, R.; Durgut, R.; Karasu, A.; Abdulhayoglu, B.The aim of the study, was to investigate the effects of desflurane and isoflurane on postanaesthetic recovery characteristics with hepatic and renal functions in dogs. Sixteen adult mongrel dogs of both sexes weighing between 16-21 kg were equally divided into 2 groups. Anaesthesia was induced with 0.3 mg kg(-1) midazolam and 10 mg kg(-1) thiopental intravenously. Maintenance of anaesthesia was continued with 7.2-8% desflurane or 1.3-1.5% isoflurane. Heart and respiration rates, arterial haemoglobin oxygen saturation and rectal temperatures were monitored before, during, 1 h and 1 day after anaesthesia periodically and postanaesthetic recovery score times were also observed. Serum alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, blood urea nitrogen, total bilirubin and creatinine levels were measured in venous blood samples. Postanaesthetic recovery scores including time to standing, time to reaching sternal recumbency, eye opening and time to extubation were found shorter in desflurane group than isoflurane group (p<0.05). Alanine aminotransferase, aspartate aminotransferase and gamma-glutamyltransferase activities were non-significantly increased in the isoflurane group and there were no change between groups. Total bilirubin and creatinine levels were non-significantly decreased, blood urea nitrogen levels were non-significantly increased within normal range during and after the anaesthesia in both groups. The present study reveals 2 important results. Firstly, desflurane provided faster anaesthetic induction, recovery with less excitation and rapid recovery times (p<0.05) and the dogs stood up in shorter time than those of isoflurane. Secondly, this study indicates that both volatile agents have no harmful side effects on renal and hepatic functions in dogs.Öğe Effects of diazepam, ketamine HCl and sevoflurane anesthesia on vital and recovery values of nine long legged buzzards (Buteo rufinus) upon wing amputation(Hellenic Veterinary Medical Soc, 2018) Isler, C. T.; Altug, M. E.; Yurtal, Z.; Deveci, M. Z. Y.In this clinical study, effects of diazepam + ketamine HCl + sevoflurane anesthesia on vital functions and recovery duration and qualityofnine long legged buzzards were evaluated upon wing amputation. Operation was decided for long legged buzzards and heartand breathingrate, body temperature, and reflexes of long legged buzzards were evaluated before, during and after the anesthesia. Diazepam and ketamine HCl injection increased the heart rate whereas it was decreased by sevoflurane. Respiratory rate decreased upon sevoflurane application. Body temperature decreased during anesthesia. Recovery began in the 3rd minute after cessation of sevoflurane administration with return of eye reflexes and completedin the 35th minute. It was observed that although birdsrecovered from anesthesia, danger of hypothermia persisted for a long time. There was a significant difference between the respiratory and heart rates during the ketamine HCl and sevofluraneanesthesia from those in the preoperative period. However, there was no statistically significant difference between pre and post operative periods in terms of vital parameters. For the first time, effects of diazepam + ketamine HCl + sevoflurane anesthesia combination on vital parameters are evaluated in long legged buzzards in Turkey.Öğe Evaluation of Tear fluid secretion and Intraocular Pressure in normal Merinos Sheep and Saanen Goats(Ecole Nationale Veterinaire Toulouse, 2013) Isler, C. T.; Altug, M. E.; Kilic, S.This study aimed at determining the effects of the species, sex and age on normal tear secretion and intraocular pressure (IOP) in normal Merinos sheep and Saanen goats, and assess the effect of topically applied atropine on tear secretions in these species. The study used a total of 80 healthy Merinos sheep, Saanen goats, Merinos lambs and Saanen kids of 20 in each. The sheep and goat aged between 1-2.5 years and the lambs and kits between 15-20 days. The lambs and kits consisted of females and males of equal numbers. Tear secretion and intraocular pressure (IOP) were measured with Schirmer Tear Test (STT) and Schiotz Tonometry, respectively. All measurements were performed prior to and five minutes after the instillation of two-four eye drops of atropine sulfate between 6 and 10 p. m for three consecutive days. The present results demonstrated that with regard to tear secretion and IOP the differences between sheep and lambs, and that between goats and kids were statistically significant (p < 0.001) whereas the differences between the sheep and goats was non-significant (p > 0.05). On the other hand, the values of tear secretion and IOP in the lambs and kids were significantly lower (p < 0.001) than those of sheep and goats. It was determined that sex variation did not significantly influence the IOP and STT values (p > 0.05) but topical atropine administration significantly reduced tear volume (p < 0.001) in all cases.Öğe The Neuroprotective and Anti-inflammatory Effects of Diltiazem in Spinal Cord Ischaemia-Reperfusion Injury(Field House Publishing Llp, 2009) Fansa, I.; Altug, M. E.; Melek, I.; Ucar, E.; Kontas, T.; Akcora, B.; Atik, E.The protective effects of diltiazem were examined in a rabbit model of spinal cord ischaemia-reperfusion induced by infrarenal aortic occlusion for 30 min. In the diltiazem group (n = 6), an intravenous infusion (2 mu g/kg per min) was started 10 min before ischaemia induction; normal saline solution was infused in the control group (n = 6). Neurological function was assessed using modified Tarlov criteria 24 h after surgery. Plasma samples were analysed for interleukin (IL)-6 and IL-10. Spinal tissue was analysed for malondialdehyde, nitric oxide and reduced glutathione activities. Tarlov scores of the diltiazem-treated rabbits indicated significantly improved hind-limb motor function compared with the control group. The diltiazem group also had better quantitative and qualitative histopathological findings. Diltiazem infusion significantly reduced IL-6 levels 3 and 24 h after reperfusion compared with the control group. The mean IL-10 level in the diltiazem group was significantly higher than in the control group 24 h after reperfusion. It is concluded that diltiazem has cytoprotective and anti-inflammatory properties, leading to reduced spinal cord injury.Öğe Prevalence of Haemoproteus and Leucocytozoon spp. in Wild Birds in Hatay, Turkey(Hellenic Veterinary Medical Soc, 2023) Zerek, A.; Erdem, I; Alakus, H.; Yaman, M.; Altug, M. E.Hemosporidian parasites that cause infections in poultry and death in susceptible animals show a global distribution. Infected wild birds play an important role in this distribution due to seasonal migration among different regions. Hatay, where migratory birds enter Turkey, is an active region regarding vectors, disease agents and hosts. This study aimed to investigate the prevalence of Haemoproteus and Leucocytozoon parasites in wild birds of Hatay Province by microscopic and molecular methods. Blood samples were taken from a total of 50 wild birds belonging to three orders, eight species. In the microscopic examination, Haemoproteus spp. infection 18% (9/50) and coinfections (Haemoproteus spp. and Leucocytozoon spp.) 4% (2/50) were detected while in the PCR examination, coinfections 4% (2/50), H. columbae 20% (10/50) and Leucocytozoon spp. 2% (1/50) were detected. As a result, haemosporidian parasites were detected in approximately one of every four wild birds (microscopic 22%, molecular 26%).
