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    Evaluation of analgesic and antiinflammatory activity of Pimpinella anisum fixed oil extract
    (2006) Tas, A.; Özbek, H.; Atasoy, N.; Altug, M. Enes; Ceylan, E.
    In this study, fixed oil of P. anisum was investigated for anti-inflammatory activity using carrageenan-induced rat paw oedema test on the Sprague-Dawley rats and analgesic activity using tail-flick test on the Swiss-albino mice. Indomethacin and etodolac were treated reference drugs for the anti-inflammatory activity. Aspirin and morphine hydrochloride were treated reference drugs for the analgesic activity. The results showed that fixed oil of P. anisum has an anti-inflammatory action more than etodolac and this effect was as strong as indomethacin. P. anisum induces analgesic effect comparable to that of 100 mg/kg Aspirin and 10 mg/kg morphine at 30 th min. of the study. Analgesic effect of P. anisum was not significant at 90 th or 150 th min. of study.
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    Is CAPE a Therapeutic Agent for Wound Healing?
    (Medwell Online, 2009) Kontas-Askar, Tuenay; Altug, M. Enes; Karapehlivan, Mahmut; Atakisi, Emine; Hismiogullari, Adnan Adil
    Wound healing involves a number of processes, including an acute inflammatory response to production of Reactive Oxygen Species (ROS) and depression in antioxidant status. The aim of the study is to examine the therapeutic effects of Caffeic Acid Phenethyl Ester (CAPE), an antioxidant agent, on cutaneous wound healing in a rat model. There was a significant decrease in serum, wound and liver tissue TSA and serum LBSA levels in the CAPE group than in the control group. Also there was a significant decrease in serum and wound tissue TAC levels of the control group when compared to the CAPE group. But there was no difference between the groups in serum ADA activity, PBSA levels and liver tissue TAC levels. In conclusion, the present study showed the CAPE's efficacy in the treatment of cutaneous wounds by its antioxidant and ROS-scavenging capabilities.