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    DICLOFENAC SPONGIOUS MATRICES BASED ON COLLAGEN AND ALGINATE FOR RELIEVING INJURY PAINS
    (Incdtp-Icpi, 2018) Draghici, Roxana-Denisa; Marin, Maria Minodora; Ghica, Mihaela Violeta; Kaya, Madalina Georgiana Albu; Anuta, Valentina; Dinu-Pirvu, Cristina; Kaya, Durmus Alpaslan
    The sport injuries become more and more frequent so there is a need to discover new solutions for increasing the quality of life for people affected by such wounds. The aim of this study was to obtain a novel NSAID drug delivery system, topical diclofenac spongious matrices based on collagen and alginate for the treatment of injuries and relieving of pain. The samples were analyzed by flow analysis and after their freeze-drying were analyzed by FT-IR and in vitro release of sodium diclofenac.The results obtained from analyses confirmed that diclofenac spongious matrices based on collagen and alginate exhibit proper characteristics for the treatment of injuries and relieving of pain.
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    Formulation and Characterization of Niacinamide and Collagen Emulsion and Its Investigation as a Potential Cosmeceutical Product
    (Mdpi, 2024) Danila, Elena; Kaya, Durmus Alpaslan; Anuta, Valentina; Popa, Lacramioara; Coman, Alina Elena; Chelaru, Ciprian; Constantinescu, Rodica Roxana
    Cosmeceuticals are one of the fast-growing areas of the natural personal care industry. Cosmeceuticals are cosmetic products with medicinal or drug-like benefits that can affect the biological functioning of the skin depending on the ingredients in the composition. The development of one formulation acting on the dermis and stimulating the collagen production is very important for the hydration of the skin. The association of collagen with other ingredients can have a positive effect on increasing the natural production of collagen in the skin. An example of such an ingredient is niacinamide, which, having a recognized nutritional value, has been quite recently studied. Considering these aspects, this study focused on developing oil-in-water (O/W) emulsions, based on natural ingredients (vegetable oils, floral waters, and essential oils) and hydrolyzed collagen and niacinamide as active ingredients, and on evaluating the stability, pH, optical, superficial, rheological and textural properties, as well as microbiological tests of the emulsions, in order to investigate their potential as a cosmeceutical product. All the obtained emulsions proved to be stable at variable temperatures and had a pH value compatible with natural pH of the skin, allowing their safe application. Over goniometric analysis, a partial wetting and a hydrophilic character of the emulsions were emphasized. Following the rheological analyses, all dermatocosmetic emulsions exhibited non-Newtonian pseudoplastic behavior and a thixotropic character, these properties being very important for their production process and their application on the skin surface to generate an optimal therapeutic effect. The textural characteristics recorded for all emulsions indicated adequate spreadability at the application site. All tested samples respected the Pharmacopoeia limits of microbiological contamination. All prepared emulsions have good stability, are safe for the skin and have appropriate physicochemical and microbiological characteristics; therefore, they can be used as a cosmeceutical product.