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Öğe Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia: etiologic and therapeutic concerns(Springer Heidelberg, 2006) Ozgocmen, S; Ozyurt, H; Sogut, S; Akyol, O; Ardicoglu, O; Yildizhan, HWe proposed to assess the oxidant/antioxidant status, lipid peroxidation and nitric oxide (NO) in untreated fibromyalgia (FM) patients and controls. The effect of amitriptyline (A, 20 mg daily) and sertraline (S, 100 mg daily) treatment on patients' superoxide dismutase (SOD), xanthine oxidase (XO), adenosine deaminase (ADA) enzyme activities, thiobarbituric acid reactive substances (TBARS) and NO levels was investigated. Thirty female patients with primary FM and age-matched 16 healthy female controls were included. Patients received an 8-week course of treatment with either A or S. FM patients had higher serum levels of TBARS (particularly malondialdehyde) and lower levels of nitrite compared to controls whereas enzyme activities were similar. A and S significantly improved Fibromyalgia Impact Questionnaire (FIQ) pain scores, Hamilton anxiety and depression rating scales. But neither A nor S had significant effects on measured oxidative stress parameters, except SOD activity that was significantly reduced after S treatment. Total myalgic scores negatively correlated with XO activity, and depression scales negatively correlated with levels of TBARS. Our results indicate that patients with FM are under oxidative stress. These findings represent a rationale for further research assessing the effect of free radical scavengers or antioxidant agents like vitamins and omega-3 fatty acids on peripheral and central mechanisms in FM.Öğe Effect of fish oil supplementation on plasma oxidant/antioxidant status in rats(Churchill Livingstone, 2004) Erdogan, H; Fadillioglu, E; Ozgocmen, S; Sogut, S; Ozyurt, B; Akyol, O; Ardicoglu, OThe aim of this study was to investigate effect of dietary omega-3 fatty acid supplementation on the indices of in vivo lipid peroxidation and oxidant/antioxidant status of plasma in rats. The plasma thiobarbituric acid reactive substances (TBARS) and nitric oxide (NO) levels, and activities of xanthine oxidase (XO), superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) were studied in male Wistar Albino rats after ingestion of 0.4 g/ kg fish oil (rich in omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid) for 30 days and compared to untreated control rats. The rats in the treated group had significantly higher SOD activity (P < 0.001), NO levels (P < 0.01) and decreased TBARS levels (P < 0.05) with respect to controls whereas GSH-Px and XO activities were not significantly different between the groups. None of the measured parameters had significant correlation with each other in both groups. We conclude that dietary supplementation of omega-3 fatty acids may enhance resistance to free radical attack and reduce lipid peroxidation. These results support the notion that omega-3 fatty acids may be effective dietary supplements in the management of various diseases in which oxidant/antioxidant defence mechanisms are decelerated. (C) 2004 Elsevier Ltd. All rights reserved.Öğe Effect of systemically applied octreotide on serum oxidanvanti-oxidant parameters and lipid peroxidation in piristane-induced arthritis(Bmj Publishing Group, 2003) Ardicoglu, O; Ozgocmen, S; Pekkutucu, I; Ozyurt, H; Sogut, S; Kamanli, A[Abstract Not Available]Öğe Oxidant/anti-oxidant status, lipid peroxidation and nitric oxide in primary fibromyalgia syndrome and the effect of anti-depressant treatment(B M J Publishing Group, 2003) Ozgocmen, S; Ardicoglu, O; Yildizhan-Bulut, H; Ozyurt, H; Sogut, S[Abstract Not Available]
