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Öğe Angioleiomyoma of the gingiva: a report of two cases(Korean Acad Oral & Maxillofacial Surgery, 2016) Arpag, Osman Fatih; Damlar, Ibrahim; Kilic, Soydan; Altan, Ahmet; Tas, Zeynel Abidin; Ozgur, TumayLeiomyoma is a type of benign smooth muscle neoplasm that is a common neoplasm of the uterus and gastrointestinal tract but rarely affects the head and neck region and is especially unlikely to affect the oral cavity. The diagnosis of leiomyoma is mainly determined by histopathological studies due to variation in its clinical appearance and symptoms. In the present paper we report two rare cases of gingival angioleiomyoma in the posterior maxilla and mandible. After total excision, hematoxylin-eosin and smooth muscle actin staining confirmed the diagnosis of angioleimyoma.Öğe Biochemical Evaluation of the Effects of Concentrated Growth Factor Liquid on Osseointegration: A Split-Mouth Design Study(Quintessence Publishing Co Inc, 2023) Atilgan, Muhammet; Arpag, Osman Fatih; Ozcan, Oguzhan; Kacmaz, FilizPurpose: To investigate cytokine levels in peri-implant crevicular fluid and thus evaluate the effects of concentrated growth factor (CGF) on osseointegration. Materials and Methods: A total of 40 mandibular implants were symmetrically placed in a group of 20 systemically healthy patients enrolled in the study. In each patient, one implant wetted with liquid infiltrated from fibrin matrix was placed in the test side (Group L), and the other implant was placed in the control side without the application of any material (Group C). Peri-implant crevicular fluid was collected at 2, 4, and 12 weeks later. Marginal bone loss was measured with panoramic radiographs taken immediately after implant placement and at 12 weeks. Resonance frequency analysis (RFA) of the implants was performed intraoperatively and at 4 and 12 weeks. Results: Stability values of the implants in the CGF liquid-treated sites were higher than those of the control group at week 12 (P =.005). There was no statistically significant difference between the two groups in terms of marginal bone loss (MBL). Group L showed increased levels of tumor necrosis factor alpha (TNF-a) and receptor activator of nuclear factor kappa-B ligand (RANKL) at 2 and 4 weeks. Also, levels of osteoprotegerin (OPG) were higher in Group L at week 4 compared to Group C (P =.033). Conclusions: The increased TNF-a, RANKL, and OPG levels in this study demonstrate that CGF liquid can be used to accelerate peri-implant bone remodeling in the early phase of osseointegration. Int J Oral Maxillofac Implants 2023:38:1182-1190. doi: 10.11607/jomi.10066Öğe Bone cutting performance and mechanical properties of piezo-surgical tips: a nano-indentation study(Cukurova Univ, Fac Medicine, 2023) Guzel, Buenyamin; Arpag, Osman Fatih; Ozarslan, Selma; Haskan, Ahmet Can; Salimov, FarizPurpose: The aims of this study were to compare the mechanical properties of piezo-surgical tips such as nano -hardness, elastic modulus, surface roughness, and wear level, and to measure their cutting performance. Materials and Methods: In this study, 31 piezo-surgical tips were used, three for control and 28 for testing. The testing tips were equally divided into four groups with different numbers of osteotomies: the four-, 8-, 16-, and 32-osteotomy groups. The mean osteotomy duration was recorded during osteotomy. Scanning electron microscopy images of the tips in the test groups were obtained before and after osteotomy, and the wear level of the tips was measured. Results: A statistically significant increase was observed in the nano-hardness of the piezo-surgical tips depending on the number of osteotomy (for 4-use; 22.47 +/- 1.67H and for 32-use; 28.49 +/- 3.42H). The elasticity value of the testing tips was in the range of 218.55 +/- 15.74E to 241.26 +/- 10.46E, and all of the values were significantly higher than those in the control group (174.39 +/- 13.53E). As the frequency of use increased, a significant increase in surface roughness was observed (from 16.67 +/- 1.50 to 56.12 +/- 2.60). A positive correlation was found between the frequency of use and the wear level of the tips, and between the surface roughness and wear level of the tips. Conclusion: With the increase in the number of osteotomies, significant changes in the mechanical and physical properties of the piezo-surgical tips that affected their bone-cutting performance were observed.Öğe Comparison of Minimum Inhibitory Concentrations of Hypericum Perforatum L. Essential Oils, 0.2 % Chlorhexidine and 10 % Povidone-iodine Over Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis(Taylor & Francis Ltd, 2020) Arpag, Osman Fatih; Duran, Nizami; Acikgul, Funda Cimen; Turkmen, MusaHypericum perforatum is a useful plant because of its biological features, such as bactericidal, virucidal, and fungicidal effects. Elimination of periodontal pathogens, including Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, from the oral environment, is important for the stability of periodontal health. Therefore, we aimed to determine the antimicrobial activity of the Hypericum perforatum L. essential oils over these pathogens using cell cultures. The standard and clinical bacterial strains were used in this study. The essential oils extracted from Hypericum perforatum L. flowers were analyzed with gaschromatography/mass spectrometry. The antimicrobial activities of the essential oils along with 0.2 % chlorhexidine, 10 % povidone-iodine, and combinations of essential oils and 0.2 % chlorhexidine, and essential oils and 10 % povidone-iodine were evaluated by measuring the minimum inhibitory concentrations. Essential oils' minimum inhibitory concentration value for clinical A. actinomycetemcomitans strains was significantly lower than that of the povidone-iodine solution (P). However, despite the low minimum inhibitory concentration value of essential oils, when compared to 0.2 % chlorhexidine, there was no statistically significant difference between the agents (P=0.113). For clinical strains of Porphyromonas gingivalis, the essential oils showed a lower minimum inhibitory concentration value compared to chlorhexidine and povidone-iodine. The essential oils combined with chlorhexidine or povidone-iodine showed significantly lower minimum inhibitory concentration value for both strains of Aggregatibacter actinomycetemcomitans (P). With the lower minimum inhibitory concentration values, the essential oils showed strong antimicrobial activity. Moreover, when combined with chlorhexidine or the povidone-iodine, the antimicrobial effect of essential oils on Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis strains increased synergistically.Öğe Effects of caffeic acid phenethyl ester on palatal mucosal defects and tooth extraction sockets(Dove Medical Press Ltd, 2014) Gunay, Ahmet; Arpag, Osman Fatih; Atilgan, Serhat; Yaman, Ferhan; Atalay, Yusuf; Acikan, IzzetAim: The purpose of this study was to evaluate the effects of caffeic acid phenethyl ester (CAPE) on palatal mucosal defects and tooth extraction sockets in an experimental model. Materials and methods: Forty-two male Sprague-Dawley rats with a mean age of 7 weeks and weighing 280-490 g were used in this study. The rats were randomly divided into two groups: group A (the control group, n=21) and group B (the experimental group, n=21). Under anesthesia with ketamine (8 mg/100 g, intraperitoneally), palatal mucosal defects were created and tooth extraction was performed in the rats in groups A and B. Group A received no treatment, whereas group B received CAPE. CAPE was injected daily (10 mu mol/kg, intraperitoneally). The rats were killed on days 7, 14, and 30 after the procedures. Palatal mucosa healing and changes in bone tissue and fibrous tissue were evaluated histopathologically. Result: Pairwise comparisons showed no statistically significant difference between days 7 and 14 in either group (P>0.05). At day 30, bone healing was significantly better in group B (CAPE) than in group A (control) (P<0.05). Fibrinogen levels at day 30 were significantly higher in group A (control) than in group B (CAPE) (P<0.05). Pairwise comparisons showed no statistically significant difference in palatal mucosa healing levels between days 7 and 14 in both groups (P>0.05). Conclusion: In conclusion, the findings of this study suggest that CAPE can significantly improve tooth socket healing.Öğe Effects of Rhinoplasty on Smile Esthetic and Gingival Appearance(Lippincott Williams & Wilkins, 2020) Arli, Cengiz; Bilgic, Fundagul; Kaya, Abdullah; Arpag, Osman FatihRhinoplasty alone or combined with septoplasty is one of the cornerstone management techniques in facial esthetic surgery. The aim of the current study was to evaluate the effects of rhinoplasty maneuvers on facial and smile esthetics. The study included a total of 27 adult patients. Measurements of gingival length (GL), right and left maxillary incisor-upper lip distance (MIULD), right and left inter-lip distance (ILD), and right and left gingival pocket depth (GPD) were performed and rounded to the nearest millimeter in full smile and at rest. All measurements were obtained at baseline and at the postoperative 1st and 6th months by the same clinician. As compared with the baseline values, significant decreases were determined in the left and right GLs in full smile, left and right MIULD, and left ILD at the postoperative 1st month and in the GL, left and right MIULD, and left and right ILD at the postoperative 6th month. In conclusion, rhinoplasty maneuvers can improve smile esthetics by changing the GL thereby increase patient satisfaction.Öğe Effects of vector ultrasonic system debridement and conventional instrumentation on the levels of TNF-? in gingival crevicular fluid of patients with chronic periodontitis(Wroclaw Medical Univ, 2017) Arpag, Osman Fatih; Dag, Ahmet; Izol, Bozan Serhat; Cimitay, Gulcan; Uysal, ErsinBackground. Tumor necrosis factor alpha (TNF-alpha) is an inflammatory mediator whose levels are increased in the gingival crevicular fluid and blood serum in the case of chronic periodontitis. Objectives. The aim of this study was to determine the effect of vector ultrasonic system (VUS) on the levels of TNF-alpha in gingival crevicular fluid (GCF) and the clinical parameters in patients with chronic periodontitis. Material and methods. The study protocol was conducted using split-mouth design in 30 patients with chronic periodontitis. VUS and scaling and root planing (S/RP) were applied separately to 2 quadrants, including the upper and the lower jaws. At baseline and after 6 months, clinical parameters including plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL) were recorded, and concentrations of TNF-alpha in GCF were determined by enzyme-linked immunosorbent assay (ELISA). Intergroup comparisons were evaluated by the independent Students' t-test, and the Pearson correlation was used to determine the relationship between parameters. The level of significance was set at 5%. Results. Both treatment modalities provided statistically significant improvements in clinical periodontal parameters and TNF-alpha levels after 6 months (p < 0.05). Also, there were no significant correlations between the TNF-alpha levels in GCF and the clinical parameters in both treatment group at baseline and at the end of 6 months period (p > 0.05). Conclusions. The use of the vector ultrasonic system in the non-surgical treatment of chronic periodontitis presents beneficial improvements for the clinical attachment level and the probing pocket depth as well as TNF-alpha levels in GCF.Öğe Elution of monomer from different bulk fill dental composite resins(Elsevier Sci Ltd, 2015) Cebe, Mehmet Ata; Cebe, Fatma; Cengiz, Mehmet Fatih; Cetin, Ali Riza; Arpag, Osman Fatih; Ozturk, BoraObjective. The purpose of this study was to evaluate the elution of Bis-GMA, TEGDMA, HEMA, and Bis-EMA monomers from six bulk fill composite resins over four different time periods, using HPLC. Methods. Six different composite resin materials were used in the present study: Tetric Evo Ceram Bulk Fill (Ivoclar Vivadent, Amherst, NY), X-tra Fill (VOCO, Cuxhaven, Germany), Sonic Fill (Kerr, Orange, CA, USA), Filtek Bulk Fill (3M ESPE Dental Product, St. Paul, MN), SDR (Dentsply, Konstanz, Germany), EQUIA (GC America INC, Alsip, IL). The samples (4 mm thickness, 5 mm diameter) were prepared and polymerized for 20s with a light emitted diode unit. After fabrication, each sample was immediately immersed in 75 wt% ethanol/water solution used as extraction fluid and stored in the amber colored bottles at room temperature. Ethanol/water samples were taken (0.5 mL) at predefined time intervals:10 m (T1), 1 h (T2), 24h (T3) and 30 days (T4). These samples were analyzed by HPLC. The obtained data were analyzed with one-way ANOVA and Tukey HSD at significance level of p < 0.05. Results. Amount of eluted Bis-EMA and Bis-GMA from Tetric Evo Ceram Bulk Fill and amount of eluted TEGDMA and HEMA from X-tra Fill higher than others composites (p < 0.05). Significance. Residual monomers were eluted from bulk fill composite resins in all time periods and the amount of eluted monomers was increased with time. (C) 2015 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.Öğe Epidermolysis Bullosa in dentistry: Report of three cases and review of the literature(University of Dicle, 2015) Arpag, Osman Fatih; Arslanoglu, Zeki; Altan, Halenur; Kale, Ediz; Bilgic, FundagulEpidermolysis Bullosa is a congenital, genetic, vesiculobullous disease. It may be autosomal dominant and recessively inherited. The major types of Epidermolysis Bullosa are Epidermolysis Bullosa Simplex, Junctional Epidermolysis Bullosa, and Dystrophic Epidermolysis Bullosa. Due to the systemic disorders specific to the Epidermolysis Bullosa patient, approach to dental care has gain importance in these cases. This article presents improving of patient comfort with oral health maintenance and atraumatic dental interventions in three cases diagnosed with Epidermolysis Bullosa and reviews the literature regarding clinical applications in brief. Three patients - one with Epidermolysis Bullosa Simplex and two with Dystrophic Epidermolysis Bullosa - were referred to our clinic by other medical institutions because of discomfort due to dental complaints. Intra and extra oral symptoms were examined and treatment plans were arranged for each one of them. Dental treatment was carried out mainly by means of establishing non-invasive methods like oral hygiene motivation along with professional debridement and radical methods like tooth extraction. All the treatments were done with precision by experienced specialists in the field of dentistry. Treated successfully the patients were taken under control for regular observation of the disease's oral symptoms.Öğe Presence of Trichomonas tenax and Entamoeba gingivalis in peri-implantitis lesions(Quintessence Publishing Co Inc, 2020) Arpag, Osman Fatih; Kaya, Ozlem MakbuleObjective:The aim was to investigate the presence of Entamoeba gingivalis and Trichomonas tenax in peri-implantitis lesions. Method and materials: A total of 141 individuals were included in this study, of which 40 had clinically healthy implants (group H); the remaining were associated with peri-implantitis (group P). Gingival crevicular fluid was collected using absorbent paper, followed by a dental plaque sample from the pen-implant sulcus/pocket using a titanium curette. The samples were transferred into an Eppendorf tube. Each specimen was divided into two parts. One part was examined under a light microscope at a 10 x and 40 x magnification to detect parasites. The other part was spread on a microscope slide, stained with Giemsa stain, and examined under a microscope at 100 x magnification. Pearson chi-square test was used in the statistical analysis of data, with a significance level of P < .05. Results: Although there was no presence of parasite around the healthy implants, two parasites were detected in peri-implantitis lesions. Out of 101 lesions, 31 (30.7%) showed Egingivalis, and 34 (33.6%) presented with T tenax. There was a statistically significant difference between the presence of Egingivalis and demographic data including gender, education status, frequency of dental visits, and brushing frequency. Presence of Ttenax in lesions was correlated with frequency of dental visits (P < .05). It was observed that E gingivalis and T tenax were mostly detected in the mandible (P = .004 and .014, respectively) in comparison with the maxilla. Conclusion: This study showed that peri-implantitis lesions were involved with E gingivalis and T tenax, in contrast to the healthy areas.Öğe Retrospective Investigation Of the Prevalence of Impacted Teeth in Hatay(Cukurova Univ, Fac Medicine, 2014) Damlar, Ibrahim; Altan, Ahmet; Tatli, Ufuk; Arpag, Osman FatihPurpose: The purpose of this study were to examine localization, the prevalence of impacted permanent teeth and to perform the distributions according to sex and jaws in Hatay population. Material and Methods: In this retrospective study, up to 5227 orthopantomograms of the patients (2865 women, 2362 men) who were referred to Mustafa Kemal University, Faculty of Dentistry, Hatay from December 2010 to June 2013 were examined. Data including the age, gender, localization were evaluated by statistical tests. Results: There were 2187 (% 41,8) patients having impacted teeth. The age of the patients ranged from 18 to 80. Among the impacted teeth, mandibular third molars were the most common (% 64,7), followed by maxillary third molars (% 30,9), maxillary canines (% 3,1), mandibular premolars (% 0,4), mandibular canines (% 0,3), maxillary premolars (% 0,2), maxillary central and lateral incisors (% 0,2), mandibular central and lateral incisors (% 0,1), mandibular first and second molarlars (% 0,07), maxillary first and second molars (% 0,03) Conclusion: In later stages of the people who lives in Hatay's life, due to complications of impacted teeth usually extracted. The impacted teeth were seen without causing any symptoms in a small part of population.Öğe To what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit model(Univ Sao Paulo Fac Odontologia Bauru, 2018) Arpag, Osman Fatih; Damlar, Ibrahim; Altan, Ahmet; Tatli, Ufuk; Gunay, AhmetAmong the many graft materials that have been used for the treatment of bone defects in oral and maxillofacial regions is xenograft. To improve osteoconductive effects of xenografts, they have been combined with various biocompatible materials, such as hyaluronic acid and bone morphogenetic protein. Objective: To determine bone-healing capacity of high molecular weight hyaluronic acid (HA) combined with xenograft in rabbit calvarial bone defects. Material and methods: Ten adult male New Zealand rabbits (mean weight 3 kg) were included in the study. Three 6-mm-diameter bicortical cranial defects were created on calvarial bone of all rabbits. These defects were filled as follows: a) xenograft; b) HA+xenograft; c) autograft. One month after the first operation, rabbits were sacrificed. Specimens were evaluated histomorphometrically. Results: Considering multiple comparisons, differences regarding new bone were statistically significant between all groups (p<0.05). The volume of residual graft was significantly decreased in HA group compared to xenograft group (p=0.035). Marrow space, trabecular thickness (TbTh), trabecular width (TbWi), trabecular separation (TbSp), and number of node: number of terminus (NNd:NTm) in the autograft group were significantly better than xenograft and HA groups (p<0.05). However, regarding marrow space, TbTh, TbWi, TbSp, and NNd: NTm values, xenograft and HA groups showed similar results and the difference were not significant (p>0.05). Conclusion: These results support that high molecular weight hyaluronic acid could contribute to the healing of xenograft by improving the percentage of new bone formation and reducing the percentage of residual graft. However, HA did not significantly affect the quality of newly formed bone assessed by microarchitectural parameters.
