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  • Küçük Resim
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    CHANGES IN THE OXIDATIVE STATUS AND SERUM TRACE ELEMENT LEVELS IN DOGS WITH MAMMARY TUMOURS
    (De Gruyter Poland Sp Zoo, 2009) Askar, T. K.; Salmanoglu, B.; Salmanoglu, R.; Erkal, N.; Beskaya, A.
    The purpose of the study was to evaluate the changes in oxidative status and serum trace element levels by determining the concentrations of malondialdehyde (MDA), nitric oxide (NO), ascorbic acid, and certain trace elements. The study included 15 clinically healthy female dogs and 15 dogs with malignant mammary tumour Blood samples were taken from the jugular vein of the patient dogs just before the surgical treatment. The patients exhibited a significant increase in MDA (P<0.001), NO (P<0.001), Fe (P<0.001), and Cu (P<0.01) levels and a significant decrease in levels of ascorbic acid (P<0.001) and Zn (P<0.01). A strong correlation was observed in the patient group for ascorbic acid and Fe (r=-0.87) concentration, but there was a weak correlation between ascorbic acid and Cu (r=-0.69), and Zn (r=0.49) concentrations. Also there was a strong correlation between Zn and MDA (r=-0.84) concentrations, indicating oxidative stress. The results suggest that ROS generated by trace elements, like Fe and Cu may cause the mammary tumours.
  • Küçük Resim
    Öğe
    Evaluation of the hormones responsible for the gastrointestinal motility in cattle with displacement of the abomasum; ghrelin, motilin and gastrin
    (Bmj Publishing Group, 2013) Ozturk, A. S.; Guzel, M.; Askar, T. K.; Aytekin, I.
    This study provides the evidence of increased serum gastrointestinal motility hormone concentrations including ghrelin, motilin and gastrin in cattle with displacement of abomasum (DA). In this study, 38 cows with DA (21 left DA (LDA) and 17 right DA (RDA)) and 15 healthy controls were included. All cattle with DA were at the stage of postpartum one to eight weeks, and had clinical signs including anorexia, decreased milk yield and scanty, pasty faeces. Serum ghrelin, motilin and gastrin concentrations, and leptin concentration which is a functional antagonist of ghrelin, were determined by ELISA. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), Na, K, Cl, Ca and P concentrations were measured by spectrophotometer. In serum biochemical analysis, increases were seen on the serum ALT, AST and GGT activities; however, serum Na, K, Cl and P concentrations decreased in abomasal displacement compared with the control animals. The serum ghrelin, motilin and gastrin concentrations increased in the cattle with LDA and RDA, as compared with those in the healthy controls. On the other hand, serum leptin concentration decreased in the cattle with DA compared with the controls. Increases in the serum ghrelin, motilin and gastrin concentrations might be attributed to activation of gastrointestinal motility hormones to enhance of gastric emptying in impaired gastric motility and/or outlet occlusion in displaced abomasum.