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    Heat shock proteins and their physiological roles
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2007) Askar, Tuenay Kontas; Ergun, Nuray; Turunc, Vecihe
    Heat shock proteins (HSPs), also called stress proteins, are a group of proteins that are present in all cells in all life forms. The synthases of these proteins are induced when a cell undergoes various types of environmental stresses like heat, cold and oxygen deprivation. In this article we summarized the structure and physiology of heat shock proteins which is an important research area for biology and medicine.
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    The Investigation of Heat Shock Protein (HSP 27), Malondialdehyde (MDA), Nitric Oxide (NO) and Interleukin (IL-6, IL-10) Levels in Cattle with Anaplasmosis
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2009) Ergoenuel, Sema; Askar, Tuenay Kontas
    Blood parasitic diseases such as tropical theileriosis in cattles are observed in Turkey. On the other hand. babesiosis and anaplasmaosis are other primer tick-borne diseases. Anaplasmosis is generalised in all over the region of Turkey. In the present study. we aimed to reveal the alterations of immune system and oxidative stress in cattles; with anaplasmosis by analysing heat shock protein (HSP 27), malondialdehyde (MDA), nitric oxide (NO), interleukin-6 (IL-6) and interleukin-10 (IL-10) levels The research has been performed on 15 healthy and 15 cattles with anaplasmosis, aged 1-3 year's old. The plasma levels of malondialdehyde and nitric oxide were determined by spectrophotometric methods while the concentrations of heat shock protein and interleukin (IL-6 and IL-10) were detected by using commercial ELISA kits. The levels of plasma MDA (P < 0.001), NO (P < 0.001). HSP 27 (P < 0.01) and serum IL-6 levels were determined significantly higher in cattles with anaplasmosis than the control group. The levels of serum IL-10 was not showed significant differences between the control and the patient group. The increases in the levels of malondialdehyde, nitric oxide, HSP 27 and interleukin-6 of the cattles with anaplasmosis may indicate the stimulation of host immune system and the existence of oxidative stress. In conclusion, determination of the levels of malondialdehyde, nitric oxide, HSP 27 and interleukin-6 might be a indicator for diagnosis of cattle anaplasmosis.