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    The Determination of Oxidative Stress by Paraoxonase Activity, Heat Shock Protein and Lipid Profile Levels in Cattle with Theileriosis
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2012) Turunc, Vecihe; Askar, Tunay Kontas
    Theileriosis is a common illness that cause large economic losses. The aim this study was to define the oxidative status by determining the changes in levels of malondialdehyde, heat shock protein, paraoxonase activity and lipid profile (triglycerides, total cholesterol, very low-density lipoprotein, low-density lipoprotein, high-density lipoprotein) in cattle with tropical theileriosis. In the study, 15 healty cattle and 15 cattle with tropical theileriosis, between 1-3 years old, were used. Plasma malondialdehyde (P<0.001) and heat shock protein 27 (P<0.01) levels were determined significantly higher in cattles with Theileriosis than the control group. On the other hand, serum paraoxonase level was significantly lower than the control group. According to lipid profile analyses, while serum trigliserid (P<0.001) and very low-density lipoprotein (P<0.01) levels were found significantly higher in cattles with theileriosis, serum total cholesterol (P<0.001), low-density lipoprotein (P<0.001) and high-density lipoprotein (P<0.001) levels were found significantly lower in cattles with theileriosis than the control group. In conclusion, serum lipid profile could play role in pathogenesis of theileriosis because of the biochemical changes, such as degeneration of liver and increased levels of lipolysis for compansate the energy requirement which was increased due to theileriosis. In addition, determination of serum paraoxonase activity and heat shock protein 27 levels may be useful tools in the determination of oxidative stress in tropical theileriosis.
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    Öğe
    Evaluation of Motility Hormones in Dairy Cattle with Omasal Impaction and Caecal Dilatation
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2015) Ozturk, Aliye Sagkan; Askar, Tunay Kontas
    The aim of this study was to evaluate the motility hormones levels in cattle with caecal dilatation (CD) and omasal impaction (OI). In this study, four cows with OI, four cows with CD (without volvulus) and ten healthy controls were used. Serum ghrelin, motilin, gastrin and leptin concentrations were determined using ELISA. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT) activities and sodium (Na), potassium (K) and chloride (Cl) concentrations were measured using a spectrophotometer. Serum ALT, AST and GGT activities were higher in OI cows. Serum Cl concentrations were lower in OI cows than in CD cows. Higher gastrin and motilin levels in OI and lower leptin levels in CD cows were found. In conclusion, this study dose not supports the use of GI motility hormones agonists in cows suffering from omasal impaction and caecal dilatation. Leptin might be indicated in negative energy balance.
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    Öğe
    Serum sialic acids, total antioxidant capacity, and adenosine deaminase activity in cattle with theileriosis and anaplasmosis
    (Natl Veterinary Research Inst, 2008) Guzel, Murat; Askar, Tunay Kontas; Kaya, Galip; Atakisi, Emine; Avci, Gulcan Erbil
    In the present study, we aimed to provide information on the serum content of sialic acids (TSA, LBSA, and PBSA), total antioxidant capacity (TAC), and adenosine deaminase (ADA) activity in cattle affected with naturally acquired theileriosis and anaplasmosis. A total of 55 Holstein cattle, comprising of 15 clinically healthy control animals, 20 cattle with theileriosis, and 20 with anaplasmosis, were used. Diagnosis was based on clinical signs, Giemsa stained blood or lymph node aspirate, and PCR assay. For the PCR assay, Tams I primers were used. The obtained results suggested that the concentration of sialic acids and ADA activity were significantly higher; and TAC were significantly lower in the theileriosis and anaplasmosis groups in contrast to the control group. In conclusion, the increased level of sialic acids and ADA in theileriosis and anaplasmosis may be attributable to the stimulation of the host immune response. In contrast, the reduced level of TAC may reflect a decrease in the antioxidant capacity.