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    Ellagic acid prevents kidney injury and oxidative damage via regulation of Nrf-2/NF-?B signaling in carbon tetrachloride induced rats
    (Springer, 2020) Aslan, Abdullah; Gok, Ozlem; Beyaz, Seda; Agca, Can Ali; Erman, Orhan; Zerek, Aykut
    Phytochemicals, bioactive food compounds, found in plants have been described as protective agents against renal injury. This work was planned to evaluate the effects of EA on anti-oxidative and anti-inflammation pathways in kidney damage induced with carbon tetrachloride. In this study, experimental animals (n = 36, 8 weeks old rats) were divided into 4 groups as follows: 1) Control group 2) EA group (10 mg/kg body weight) 3) CCl4 group (1.5 ml/kg, body weight) 4) EA + CCl4 group. The potentially protective effect of EA on kidney damage exposed by CCl4 in rats were evaluated. EA administration protects CCl4 induced kidney damage against oxidative stress through its antioxidant protection. Treatment of EA significantly reduced lipid peroxidation and improved glutathione and catalase enzyme activity. Recently studies showed that EA activated caspase-3 and nuclear transcription factor erythroid 2 related factor driven antioxidant signal pathway and protected the kidney against damage induced by oxidative stress. Furthermore, EA also markedly decreased the level of cyclooxygenase-2, the vascular endothelial growth factor and tumor necrosis factor-alpha and suppressed the protein synthesis of nuclear factor-kappa-B. This study reveals that EA has kidney protective effect against CCl4 induced oxidative damage and inflammation. [GRAPHICS] .
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    The protective effect of Boswellic acid and Ellagic acid loaded, colon targeted, and pH-sensitive N-succinyl chitosan in ulcerative colitis rat model
    (Elsevier, 2022) Yipel, Mustafa; Tekeli, Ibrahim Ozan; Altinok-Yipel, Fulya; Coskun, Pinar; Aslan, Abdullah; Guvenc, Mehmet; Beyazit, Neslihan
    Targeted drug delivery systems that provide therapeutic activity with lower concentrations of both herbal and other substances, while reducing access to non-target sites and undesirable effects; have an important potential for future projections in terms of pharmacological and toxicological studies. The present study aimed to investigate the protective effects of Acetyl 11-keto-beta-boswellic acid (AKBA) and Ellagic acid (EA) loaded, colon targeted, and pH-Sensitive N-succinyl chitosans (NsCh) in ulcerative colitis (UC) model induced by acetic acid (AA) in rats. The physicochemical characterization (elemental analysis, FT-IR, DSC, XRD, SEM, NMR) analyses, swelling, and releasing tests of NsCh's suggested that AKBA and EA were successfully loaded to pH-sensitive polymer and targeted to the colon. The targeted AKBA and EA were administered to Wistar rats (n:30, 5 groups) and damage, inflammatory cytokine, protein expression, oxidative stress, and antioxidant parameter levels in colon tissues of the groups were determined. Increase in the levels of CAT, GPx activities, and decrease in necrosis, inflammation, and levels of MDA, TNF-alpha, COX-2, NF-kB were observed in the targeted EA and AKBA groups compared to the UC group. The potential protective effect of EA and AKBA loaded, colon-targeted, pH sensitive controlled releasing system against UC and the potential to be licensed preparations by completing the next stages of in vitro and in vivo studies were demonstrated.
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    Protective effect of Diospyros kaki L. leaves extract against oxidative damage and inflammation in the testicular ischemia-reperfusion model in rats
    (Natl Inst Science Communication-Niscair, 2023) Yurtal, Ziya; Kulualp, Kadri; Oezkan, Hueseyin; Kutlu, Tuncer; Alakus, Halil; Aslan, Abdullah; Altug, Muhammed E.
    The Oriental persimmon, Diospyros kaki L., native of China, with its bioactive compounds from leaves, flavonoids and polyphenols in particular, possess antibacterial, antiallergic, anti-inflammatory, neuroprotective and antihypertensive properties. Though, the anti-inflammatory and antioxidative effects of the D. kaki leaves have beneficial effects in I/R injury in the brain, the same has not been investigated in testicular I/R injury until now. Hence, in the present study, we investigated its leaf extract against oxidative damage and inflammation in the testicular ischemia-reperfusion model. Thirty-two male rats were randomly and equally divided into four groups. While saline (SF) was given to the control and ischemia/reperfusion (I/R) groups for 5 days, Diospyros kaki (DK) and I/R+DK were given 200 mg/kg of DK leaf extract. Afterwards, left orchiectomy was performed in control and DK, and testicular torsion was performed in I/R and I/R+DK for 2 hours. All rats were sacrificed 24 hours after procedures and samples were collected. Compared to the control, I/R had high MDA levels, low GSH and GSH-Px levels; compared to the I/R, MDA levels of the I/R+DK were lower, and the GSH and GSH-Px levels were higher. In I/R, the presence of congestion and hemorrhage were determined and the deterioration in seminiferous tubule structure and spermatogenesis were less in the I/R+DK. TNF-alpha, COX-2, BCL-2, and BAX genes expressions were significantly lower in the I/R+DK group. TNF-alpha and COX-2 proteins were higher in I/R and I/R+DK groups, while NRF2 was higher in I/R+DK. These results show that DK leaves extract has crucial protective effect against oxidative damage and inflammation in the I/R model of rats.
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    Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats
    (Springer Basel Ag, 2019) Tekeli, Ibrahim Ozan; Atessahin, Ahmet; Sakin, Fatih; Aslan, Abdullah; Ceribasi, Songul; Yipel, Mustafa
    ObjectiveTo compare the potential protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in rats.MethodsConventional and colon-targeted LC (10mg/kg) and LN (200mg/kg) were administered in vivo orally for 7days and sulfasalazine (100mg/kg) was also used as reference drug. Then, 4% AA was administered intrarectally to induce UC. Subsequently, the colon tissues were taken as samples for biochemical and histopathological analysis.ResultsMalondialdehyde (MDA), interleukin 1 (IL-1), IL-6, cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-B) levels were decreased (p<0.05) in the targeted groups compared to the AA group, whereas nuclear factor-erythroid 2-related factor 2 (Nrf-2) level was increased (p<0.05). Tumor necrosis factor (TNF-) level was also decreased (p<0.05) and catalase activity (CAT) was increased (p<0.05) in the TLC group compared to the AA group. IL-1 and IL-6 levels were lower in the TLC group compared to the conventional LC and sulfasalazine groups (p<0.05). COX-2 and NF-B levels were lower, while the Nrf-2 level was higher in the targeted groups compared to the conventional groups (p<0.05). Furthermore, COX-2 level was lower and Nrf-2 level was higher in the targeted groups compared to the sulfasalazine group (p<0.05).ConclusionAs expected, sulfasalazine was effective on all parameters analyzed, but the colon-targeted pretreatments were more effective from sulfasalazine on some parameters. Therefore, colon-targeted plant-derived therapies might be alternative approaches to provide protection against UC, which deserves to be investigated further.