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Öğe GASTRIC CANCER IN DIFFERENTIALDIAGNOSIS OFHYPEREMESIS GRAVIDARUM: CASE REPORT(Galenos Yayincilik, 2008) Aslan, Erdogan; Simsek, Erhan; Kilicdag, Esra; Bolat, Filiz; Nursal, Tarik Zafer; Haydardedeoglu, BulentGastric cancer in pregnancy is rare and, portends a grave prognosis probably due to its relatively late diagnosis at an advanced state. Because many nonspecific gastrointestinal symptoms are attributed mainly to nausea and vomiting of pregnancy which is a broad term and hesitation may exist subjecting pregnant women to extensive diagnostic procedures, delay in diagnosis usually ensues. A 30-year-old multigravida in her 22nd week of gestation was referred to our institution because of nausea, vomiting, heartburn, and epigastric pain resistant to therapy with antiacid, sucralfate, H2 receptor blockers, antibiotics and, antispasmodics which were given on multipl occations throughout her pregnancy. In abdominal ultrasonography a mass lesion adjacent to liver was detected. Gastric carcinoma was diagnosed by biopsy taken by endoscopy. The patient and family decided not to terminate the pregnancy. At 24th week of gestation subtotal gastrectomy, gastrojejunostomy, Witzel jejunostomy, and lymphadenectomy procedures were performed. Histopathology confirmed signet cell type gastric carcinoma. After corticosteroid therapy a 1450 gr weighing male baby was delivered by c/ s at 29 week and 3 days of gestation with the parents' insistence in order to institute chemotherapy as soon as possible. The baby was discharged from neonatal intensive care unit after 5 days. The patient is alive and disease free at 36 months postoperatively.Öğe THE INFLUENCE OF HORMONAL STATUS AND SOCIO-CULTURAL DETERMINANTS ON POSTMENOPAUSAL SEXUAL DYSFUNCTION(Galenos Yayincilik, 2008) Aslan, Erdogan; Pocan, Gurhan A.; Dolapcioglu, Kenan; Savas, Nazan; Bagis, TayfunObjective: To evaluate the hormonal and psycho-socio-cultural determinants that effect postmenopausal sexual dysfunction. Design: Case-control study. Setting: University hospital, Menopause clinics. Patients: 50 volunteers fit for inclusion criteria. Intervention: FSFI questionaire was applied to the participants after initial interview that preset questions evaluating psycho-socio-cultural determinants were directed. Vaginal pH, total testosterone, and SHBG levels were measured in addition to routine menopause investigations. Results: FSFI scores were accordingly low in women who considered that they had a sexual dysfunction (50%) and, in those who felt menopausal transition had a negative impact in their sexual relations (52%) (p=0.00). While 6% of participants found sex after menopause as either shameful-unappropriate or unnecessary, other 17% stated that sex after menopause should continue as a duty of woman. 33% of the participants outlined that motherhood is the most important goal of their lives. Stepwise logistic regression analysis revealed a correlation between FSFI scores and FAI. Conclusion: FSD is prevalent in our country. Questioning the patient about the presence of sexual dysfunction may be sufficient to disclose the problem. FAI is a more reliable parameter in selecting candidates for androgen therapy.Öğe The influence of Theranekron® on glucose-6-phosphate dehydrogenase activity in rat ovaries, intact and with ischemia-reperfusion injury(Univ Zagreb Vet Faculty, 2021) Kozlu, Tolunay; Guler, Fatma; Akalin, Pinar Peker; Kazak, Filiz; Ergun, Yasar; Aslan, ErdoganThe effect of Theranekron (R) on rat ovaries was evaluated in healthy and ischemia-reperfusion injury models. The rats were divided into four groups: group 1: control, group 2: Theranekron (R) (single dose of 0.3 mg/kg intraperitoneally), group 3: torsion + detorsion, and group 4: torsion + detorsion + Theranekron (R) (single dose 0,3 mg/kg. intraperitoneally). The ovaries were homogenized by sonication before the analysis and supernatant glucose-6-phosphate dehydrogenase activity, reduced nicotinamide adenine dinucleotide phosphate, reduced glutathione and total protein levels were evaluated spectrophotometrically. Ovary tissues were histologically examined. In group 2, glucose-6-phosphate dehydrogenase activity was significantly reduced (P<0.01) compared to the control group and an increased number of atretic follicles, and hyperaemic and haemorrhagic regions were seen histologically: in group 3. although glucose-6-phosphate dehydrogenase activity was not changed, intense hyperaemia and hemorrhage was observed in the veins of the medulla region and in the cortex. Group 4 showed a decrease in glucose-6-phosphate dehydrogenase activity compared to the control group (P<0.01). Histologically, when compared to group 3, group 4 showed fewer atretic follicles and decreased hyperaemia and hemorrhage in the ovaries, excluding the medulla region. There were no significant differences regarding reduced glutathione and reduced nicotinamide adenine dinucleotide phosphate levels between the groups. The Theranekron (R) dose applied had some negative effects, such as reduced glucose-6-phosphate dehydrogenase activity. an increased number of atretic follicles, and hyperemia in the corpus luteum and medulla region in intact rat ovaries. Although it reduced glucose-6-phosphate dehydrogenase activity, Theranekron (R) may have had slight remedial effects on rat ovaries with ischemia-reperfusion injury.Öğe Intraoperative mapping of anal and perineal anatomy using an electrostimulator(John Wiley and Sons Ltd, 2008) Aslan, ErdoganObjective: To present a new technique to identify perineal and anal sphincter anatomy using an electrostimulator in order to facilitate anatomical repair. Methods: A neglected perineal tear was repaired using the technique described. Results: The patient's St Mark's incontinence score improved from 22 out of 24 to 6 out of 24. Conclusions: This technique may be practical and useful for intraoperative mapping of distorted perineal and anal anatomy to assist surgical repair. © 2008 International Federation of Gynecology and Obstetrics.Öğe A right sliding indirect inguinal hernia containing paraovarian cyst, fallopian tube, and ovary: a case report(Springer Heidelberg, 2009) Ozkan, Orhan Veli; Semerci, Ersan; Aslan, Erdogan; Ozkan, Sebiha; Dolapcioglu, Kenan; Besirov, ElmirAlbeit very uncommon, the hernia sac may contain unusual structures such as vermiform appendix, acute appendicitis, ovary, fallopian tube and, urinary bladder. Most of the cases of hernia containing ovary and fallopian tubes were reported to be found in children and, often accompanied with other congenital anomalies of genital tract. We present the first case of sliding inguinal hernia containing right ovary and fallopian tube and a right paraovarian cyst in 80-year-old, multiparous patient without any associated genital anomaly. The hernia was repaired with plication darn, while the paraovarian cyst was excised and adnexa were preserved. It is of utmost importance to keep in mind that the hernia sac may contain almost any abdominal organ, and surgical dissection should be carried out accordingly. Pathophysiologically, the ovary might be simply pulled along with a sliding paraovarian cyst or the paraovarian cyst might be accompanying the maldescended ovary. There seems to be a need for clinical and experimental studies to further explain the mechanisms that apply to the pathogenesis of sliding inguinal hernias.Öğe Theranekron for treatment of endometriosis in a rat model compared with medroxyprogesterone acetate and leuprolide acetate(Elsevier, 2013) Dolapcioglu, Kenan; Dogruer, Gokhan; Ozsoy, Sule; Ergun, Yasar; Ciftci, Sinasi; Karapinar, Oya Soylu; Aslan, ErdoganObjectives: The aim of this study was to compare the effects of theranekron, medroxyprogesterone acetate (MPA), and leuprolide acetate (LA) on surgically induced endometriosis in a rat model. Study design: Endometriosis was surgically induced in forty female rats during estrus. After 3 weeks, a second operation was performed and the rats were randomized using a randomization table into theranekron, MPA, LA, and control groups. These treatments were continued for 3 weeks. A third operation was performed to evaluate treatment results. Then, the experimental treatments were halted and estrogen was initiated again to maintain estrus. After three additional weeks; i.e. after 9 weeks, the recurrence rate of endometrial foci was evaluated in a fourth operation and the rats were sacrificed. The volume of endometriotic foci and histopathology scores before and after treatment were compared. Results: The respective mean volumes of the endometriotic foci after 3, 6, and 9 weeks were 86.4 +/- 21.2, 16.4 +/- 8.2, and 20.1 +/- 9.6 mm(3) in the theranekron group, 78.3 +/- 20.4, 42.6 +/- 13.5, and 66.7 +/- 16.2 mm(3) in the MPA group, and 91.8 +/- 30.2, 34.4 +/- 11.4, and 72.4 +/- 21.9 mm(3) in the LA group. The respective mean histopathology scores were 2.4 +/- 0.6, 1.8 +/- 0.6, and 1.6 +/- 0.6 in the theranekron group, 2.5 +/- 0.8, 2.0 +/- 1.1, and 2.7 +/- 1.0 in the MPA group, and 2.3 +/- 0.5, 2.1 +/- 1.2, 2.4 +/- 0.8 in the LA group. After 9 weeks, the mean volume of endometriotic foci and histopathology scores were significantly lower in the theranekron group. Conclusions: Theranekron caused more evident regression of endometriotic foci than MPA or LA in a rat model. After stopping the theranekron treatment, the recurrence rate was also lower than that of the other groups. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
