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    Öğe
    Does helicobacter pylori cause psychiatric symptoms in dyspeptic patients?
    (Acta Medica Mediterranea, 2014) Kivrak, Yuksel; Kokacya, Hanifi; Copoglu, Umit Sertan; Dokuyucu, Recep; Ari, Mustafa; Sulu, Barlas; Atalay, Eray
    Objective: A good deal of researches regarding dyspepsia and Helicobacter Pylori (Hp), which are among the most important health problems, have been held. Both Hp and psychiatric symptoms can affect dyspepsia. However, it has not been researched whether Hp causes the psychiatric symptoms or not. In this study, it has been researched whether HP causes the psychiatric symptoms or not. Method: of the patients who applied with the problem of dyspepsia and were directed for endoscopy, 118 were evaluated. Scl-90 scale was applied. Those who proved biochemically and histopatologically HP and those who do not were compared. Results: It has been established that there is no meaningful difference in both groups in terms of somatization, obsessive-compulsive features, sensibility in interpersonal relations, anxiety, anger and hostility, phobic anxiety, paranoid thinking and psychoticism. While HP group got higher scores from the sub-groups of anxiety, obsession, depression, interpersonal sensibility, psychotic, paranoid and General Symptom Index , the HP (-) group got higher scores from sub-scales of somatization, anger and from additional ones. The scores that the both groups have obtained from the somatization sub-scale are above eleven, which is cutoff score. Besides the group with HP (+) has been detected to get a score over 1 from the subscales of anxiety, obsession, depression and interpersonal sensibility. Conclusion: HP does not cause psychiatric symptoms. Individuals who suffer from dyspepsia had better get examined.
  • [ N/A ]
    Öğe
    DOES HELICOBACTER PYLORI CAUSE PSYCHIATRIC SYMPTOMS IN DYSPEPTIC PATIENTS?
    (Carbone Editore, 2014) Kivrak, Yuksel; Kokacya, Hanifi; Copoglu, Umit Sertan; Dokuyucu, Recep; Ari, Mustafa; Sulu, Barlas; Atalay, Eray
    Objective: A good deal of researches regarding dyspepsia and Helicobacter Pylori (Hp), which are among the most important health problems, have been held. Both Hp and psychiatric symptoms can affect dyspepsia. However, it has not been researched whether Hp causes the psychiatric symptoms or not In this study, it has been researched whether HP causes the psychiatric symptoms or not. Method: of the patients who applied with the problem of dyspepsia and were directed for endoscopy, 118 were evaluated. Scl-90 scale was applied. Those who proved biochemically and histopatologically HP and those who do not were compared. Results: It has been established that there is no meaningful difference in both groups in terms of somatization, obsessive-coin. pulsive features, sensibility in interpersonal relations anxiety anger and hostility, phobic anxiety, paranoid thinking and psychoticism. While HP group :got higher scores from the sub groups of anxiety, Obsession, depression, interpersonal sensibility, psychotic, paranoid and General Symptom Index, the HP (-) group got higher scores from sub scales of somatization, anger and from additional ones. The scores that the both groups have obtained from the somatization sub scale are above eleven;. which is cutoff score. Besides the group with Hp (+) has been detected to get a score. over I from the subscales of anxiety, obsession, depression and interpersonal sensibility. Conclusion: HP does not cause psychiatric symptoms: Individuals who suffer from dyspepsia had better get examined.
  • Küçük Resim
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    Lack of association between obstructive sleep apnea syndrome and specular microscopic features of the corneal endothelium
    (Springer Heidelberg, 2021) Cakmak, Ayse Idil; Dikmen, Nursel; Eren, Ela; Atalay, Eray
    Background Obstructive sleep apnea syndrome (OSAS) is characterized by recurrent episodes of hypoxemia and hypercapnia during sleep. The aim of this study was to determine whether OSAS causes significant changes in corneal endothelium detectable by specular microscopy. Methods This prospective, cross-sectional study compared the specular microscopic features of the corneal endothelium of patients with OSAS and age-and gender-matched controls. Patients diagnosed with OSAS by polysomnography in the sleep unit were classified using apnea-hypopnea indexes into two groups as mild-moderate OSAS group and severe OSAS group. All participants were divided into three age groups: 30-45, 46-60, and > 60 years. Corneal endothelial cell density (ECD), percentage of hexagonal cells (Hex), and coefficient of variation of cell area (CV) were obtained using a non-contact specular microscope. The measurements of each group were compared statistically. Results A total of 66 patients (51.1 +/- 9.4 years) and 88 controls (49.2 +/- 10.5 years) were examined. The mild-moderate OSAS group and the severe OSAS group had no significant differences in measures of specular microscopy compared with the controls (ECD, p = 0.84; Hex, p = 0.18; CV, p = 0.41). The mean values of ECD, Hex, and CV were 2552.56 +/- 302.49 cells/mm(2), 54.13 +/- 8.13%, and 36.41 +/- 5.92, respectively, in the mild-moderate OSAS group; 2510.52 +/- 377.12 cells/mm(2), 54.85 +/- 8.68%, and 34.77 +/- 5.02, respectively, in the severe OSAS group; 2543.37 +/- 286.94 cells/mm(2), 51.89 +/- 9.09%, and 36.03 +/- 5.32, respectively, in the control group. Conclusions There were no significant differences in corneal endothelial features between patients and controls. Although OSAS causes systemic hypoxia, its effects do not appear to result in corneal endothelial alterations detectable by specular microscopy.
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    Optical coherence tomography angiography analysis of fabry disease
    (Springer, 2020) Cakmak, Ayse Idil; Atalay, Eray; Cankurtaran, Veysel; Yasar, Erdogan; Turgut, Faruk Hilmi
    Purpose Fabry disease (FD) is characterized by a deficiency in alpha-galactosidase A activity that leads to the cumulative deposition of unmetabolized glycosphingolipids within organs, including the vascular endothelium and the eyes. The purpose of this study was to assess the effects of FD on the retinal microvasculature, foveal avascular zone (FAZ), macular thickness and retinal nerve fiber layer (RNFL) using optical coherence tomography angiography (OCT-A). Methods Twenty-five patients (14 female and 11 male; mean age 33.16 +/- 11.44) with genetically verified FD were compared with 37 age- and sex-matched healthy controls (mean age 32.36 +/- 15.54). The vessel density (VD) values of the superficial and deep capillary plexuses (SCP and DCP), the area of the FAZ, the density of radial peripapillary capillaries (RPC), the macular thickness and the retinal nerve fiber layer thickness were measured by OCT-A examination. Results The patients showed significantly lower VD values than controls in the foveal regions of both SCP and the DCP (21.15 +/- 5.56 vs. 23.79 +/- 4.64 (p = 0.048), 37.92 +/- 6.78 vs. 41.11 +/- 5.59 (p = 0.048), respectively). The FAZ was significantly larger in the FD group than in the control group (0.3 +/- 0.1 vs. 0.24 +/- 0.08 (p = 0.011)). No significant difference was identified in measurements of RPC density, peripapillary RNFL thickness or macular thickness between the two groups (p > 0.05 for all). Conclusion Decreased VD and an enlarged foveal avascular area suggest possible changes in the retinal microvasculature of patients with FD. OCT-A can serve as a useful, noninvasive, quantitative tool for diagnosing FD and monitoring its progression.
  • Küçük Resim
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    Systemic and ocular determinants of mean ocular perfusion pressure in a population-based sample
    (Springer Japan Kk, 2020) Cakmak, Ayse Idil; Atalay, Eray; Gultekin Irgat, Saadet; Koktas, Zulfiye; Yildirim, Nilgun
    Purpose To investigate the associations between mean ocular perfusion pressure (MOPP) and several variables including body mass index (BMI), comorbid medical conditions and various ocular parameters in a population-based sample. Study design Cross-sectional. Methods Data of 2091 healthy participants from a previous population based cross-sectional study were reviewed. Inclusion criteria were adults >= 40 years of age who were screened on-site for glaucoma. Data on medical history, height, weight, systolic and diastolic blood pressures (SBP and DBP, respectively) were obtained. A basic ocular examination was performed which included intraocular pressure (Tono-Pen XL, Reichert Technologies) and central corneal thickness (Pacline pachymetry;) measurement, slit-lamp examination and non-mydriatic optic disc photography (nonmyd alpha fundus camera, Kowa). MOPP was calculated using the formula [2/3 x (DBP + 1/3(SBP-DBP)]-IOP and low MOPP was defined as MOPP <= 45 mmHg. Results Mean age of the subjects was 63.04 +/- 9.7 years (range: 44 and 99 years) and the majority were women (74.1%, n = 1549). Mean MOPP values in normal weight (BMI < 25), overweight (BMI = 25-29.9) and in obese individuals were 46.9 +/- 9.0 mmHg, 48.6 +/- 9.2 mmHg and 50.7 +/- 10.0 mmHg, respectively (p < 0.001, in all pairwise comparisons). In the multivariable logistic regression analysis, migraine and IOP elevation (per 1 mmHg increment) were significantly associated with a low MOPP (OR: 2.10 and 1.22, p = 0.008 and < 0.001, respectively). On the other hand, risk of low MOPP was reduced in subjects with hypertension, and with increasing age (per 1-year increment) and BMI (per 1-unit increment) (OR: 0.15, 0.97, and 0.95, respectively, and p < 0.001 for all). Conclusion Migraine and elevated IOP increase the risk of low MOPP and this may have a causal relationship with impaired optic nerve head blood flow.