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    Antimicrobial and antioxidant activities of medicinal plant Glycyrrhiza glabra var. glandulifera from different habitats
    (Taylor & Francis Ltd, 2016) Karahan, Faruk; Avsar, Cumhur; Ozyigit, Ibrahim Ilker; Berber, Ismet
    In this study, the antimicrobial and antioxidant activities of root methanolic extracts of Glycyrrhiza glabra var. glandulifera (Waldst. & Kit.) Boiss. (Fabaceae) were investigated. Plant samples were collected from different habitats in the East Mediterranean part of Turkey. The plant extracts were evaluated for antimicrobial activities against nine bacterial and two yeast strains using disc-diffusion and minimum inhibitory concentration methods. The antioxidant activity was determined by using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The antimicrobial assays indicated that the plant root extracts were more effective against Gram-positive bacteria than against Gram-negative ones. In addition, the extracts had higher antimicrobial effect against Candida species than against bacteria. The extracts showed good antioxidant activity, with a median inhibitory concentration (IC50) in the range of 588 +/- 0.86 mu g/mL to 2190 +/- 1.73 mu g/mL. Results indicated that different environmental conditions in each habitat might affect the contents of chemical compounds and biological activity in the natural licorice populations of. This study also supported the traditional use of licorice and as well as suggested that it may also be its beneficial role in the treatment of other infections. The obtained results indicated that different environmental conditions in each habitat might affect the contents of chemical compounds and the biological activity in the natural licorice populations.
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    Comparative Study on Phytochemical Profiles, Antiproliferative, Antimicrobial and Antioxidant Activities of Adonis Species from Turkey
    (Springer, 2022) Karahan, Faruk; Avsar, Cumhur; Turkmen, Musa; Gezici, Sevgi; Ilcim, Ahmet
    The present study aimed to determine antiproliferative, antimicrobial, antioxidant activities and also phytochemical composition of different nine Adonis L. species from Turkey. Leaves extracts of the plant samples were used to evaluate antimicrobial activity against 7 bacteria and 2 yeast strains using MICs and disc-diffusion methods. The antioxidant activity of plant samples was determined by using DPPH radical scavenging activity method. MTT assay was used for evaluation antiproliferative activities of the extracts against HL-60, HCA-7 and HUVEC human cells. Chemical composition of plant extracts were determined by Gas Chromatography/Mass Spectrometry. The antimicrobial analyses results showed Gram-negative bacteria more sensitive than Gram-positive against the extracts, and the values were varied from 3.1 to 13.4 mu g/mL. The leaf extract of different Adonis species exhibited remarkable antiproliferative activities towards tested human cancer cells in a dose and time dependently, and they were found to possess more antiproliferative activity against HL-60 cells than that of the HCA-7 cells. As for the chemical composition of Adonis species, they were found to contain many components with antimicrobial and beneficial effects, such as ethyl palmitate, ethyl linoleate. Overall, it was concluded that leaves extracts of Adonis species could have a great potential for use in medicinal drug sources.
  • Küçük Resim
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    Phytochemical Profiling and In Vitro Antioxidant, Antimicrobial, Cytotoxicity Effects of Some Glycyrrhiza Species from Turkey
    (Springer, 2024) Karahan, Faruk; Tuerkmen, Musa; Avsar, Cumhur; Gezici, Sevgi
    Glycyrrhiza (licorice) species, known as the grandfather of herbs is one of the most popular medicinal plants used in traditional medicines and ethnobotany since ancient times. The present study aimed to determine the chemical composition, anti-cancer, antimicrobial and antioxidant activities of Glycyrrhiza glabra L., G. flavescens Boiss., and G. echinata L. taxa from different ecological conditions in Turkey. Root and leaf extracts of the plant samples were used to evaluate antimicrobial activity against 7 bacteria and 2 yeast strains using MICs and disc-diffusion methods. The antioxidant activity of plant samples was determined by using the DPPH radical scavenging activity method. The antimicrobial analysis results show that Gram-negative bacteria are more sensitive to the extracts than Gram-positive, and antimicrobial values of the root extracts were also more effective than the leaf extracts. The antioxidant activities of the extracts varied from 4.2 to 2196 mu g/mL. Cytotoxicity activities of the Glycyrrhiza extracts were assessed in NCI-N87, LNCaP, and BxPC-3 human cancer cells, and the extracts exhibited remarkable activities towards the cells, with the IC50 value ranging from 16.28 +/- 1.08 to 171.04 +/- 0.68 mu g/mL. Moreover, the chemical contents of the extracts were analyzed, and toluene, phenol, palmitic acid, chroman, butyric acid and lidocaine were determined in both the roots and leaves of the extracts. In the present study, our results also revealed that ecological conditions might affect the chemical content and biological activities of the extracts. Overall, it was found that the tested Glycyrrhiza extracts could have rich sources of medicinal drugs and natural plant products in the future.