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Öğe Anti-inflammatory and antioxidant activity of thymoquinone in a rat model of acute bacterial prostatitis(Sage Publications Ltd, 2013) Inci, M.; Davarci, M.; Inci, M.; Motor, S.; Yalcinkaya, F. R.; Nacar, E.; Aydin, M.Prostatitis plays a major role in morbidity and mortality related to prostate diseases. The aim of this study was to detect whether thymoquinone (TQ) could ameliorate oxidative damage and the proliferative response induced by Escherichia coli (E. coli) in rats. A total of 42 adult male Wistar rats were used. The rats were randomly divided into seven groups (three treatment groups, three infected groups and one control group). Control group received saline and was killed 24 h after saline administration. Infected rats were killed after 24, 48 and 72 h following direct injection of E coli into the prostate. Treatment groups were administered with 10 mg/kg dose of TQ intraperitoneally following E. coli injection and after 24 and 48 h following E. coli injection. The rats were killed at 24, 48 and 72 h after the first drug administration. Each group was compared with each other and with the control group. In addition, infected groups were compared with treatment groups. Our findings show that the treatment with TQ has a protective effect against bacterial prostatitis-induced tissue injury. Increase in malondialdehyde levels and histological damage caused by E. coli were improved markedly with TQ treatment. TQ treatment particularly increased the activity of glutathione peroxidase and decreased the activities of catalase and superoxide dismutase. These observations might be attributed, at least in part, to the antioxidant effect of TQ and suggest that it could be a clinically valuable agent in the prevention of acute prostatitis caused by E. coli.Öğe BENEFICIAL EFFECT OF ERDOSTEINE ON METHOTREXATE-INDUCED TESTICULAR TOXICITY IN MICE(Elsevier Science Bv, 2010) Oktar, S.; Gokce, A.; Aydin, M.; Davarci, M.; Meydan, S.; Ozturk, O. H.; Koc, A.[Abstract Not Available]Öğe Direct and indirect effects of kisspeptin on liver oxidant and antioxidant systems in young male rats(Wiley, 2010) Aydin, M.; Oktar, S.; Yonden, Z.; Ozturk, O. H.; Yilmaz, B.Kisspeptin is a recently discovered hypothalamic peptide which plays an important role in the central control of reproductive functions We have investigated direct and indirect effects of kisspeptin on the liver oxidative stress in young male rats Twenty-four rats were divided into four groups (n = 6/group) First group served as control and received saline. Kisspeptin-10 was administered to the animals in the second group (20 nmol/rat/day), for a period of 7 days Rats were given only one dose gosereline (0 9 mg/rat), a GnRH agonist in the third group The last group received kisspeptin-10 with gosereline. The activities of catalase, superoxide dismutase (SOD), xanthine oxidase (XO), adenosine deaminase (AD) and level of malondialdehyde were studied in liver tissue Serum samples were separated for total antioxidant capacity (TAC), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, blood urea nitrogen (BUN), colesterol, lipoprotein (HDL) and triglyceride. Kisspeptin increased the activities of SOD and catalase (p < 0 05) When compared to the control group. the levels of malondialdehyde. TOS and AST were lower, but levels of BUN, cholesterole, HDL and AD were higher in the other three groups (p < 0.05) In conclusion, our findings suggest that kisspeptin may have antioxidant and thus protective effects on the liver tissue Copyright (C) 2010 John Wiley & Sons, LtdÖğe Effects of Composted Municipal Solid Wastes on Phenology and Yield Characteristics of Wheat (Triticum aestivum L.) in Eastern Mediterranean Region(Asian Journal Of Chemistry, 2009) Sener, O.; Aydin, M.; Tiryakioglu, M.This study was carried out to evaluate the effects of compost application produced from municipal solid wastes on growth and yield of wheat under semi-arid Mediterranean conditions. The compost was produced from mainly house-originated solid wastes, bay leaves and farmyard manure mixture in a ratio of 7.5:1.5:1.0, respectively. The treatments were: chemical fertilizer (160 kg N ha(-1) and 80 kg P2O5 ha(-1)); 20, 40, 60 and 80 tons compost ha(-1); 80 tons animal manure ha(-1) and control without treatments. The experimental design was randomized blocks with three replications. According to the results of a three-year experiment, application of 20 tons of compost ha(-1) appeared to be the most suitable treatment for satisfied yield. Moreover, some positive effects of the compost application on growth parameters of wheat were observed.Öğe Effects of letrozole on biochemical markers of bone and liver(Amer Assoc Clinical Chemistry, 2008) Yonden, Z.; Aydin, M.; Alcin, E.; Yilmaz, B.[Abstract Not Available]Öğe Effects of letrozole on bone biomarkers and femur fracture in female rats(Servicio Publicaciones Universidad Navarra, 2009) Yonden, Z.; Aydin, M.; Alcin, E.; Kelestemur, M. H.; Kutlu, S.; Yilmaz, B.Z. YONDEN, M. AYDIN, E. ALCIN, M.H. KELESTEMUR, S. KUTLU and B. YILMAZ. Effects of letrozole on bone biomarkers and femur fracture in female rats. J Physiol Biochem, 65 (3), 267-276, 2009. We aimed to investigate the effects of the aromatase inhibitor letrozole on femur fracture and serum levels of alkaline phosphatase (ALP), calcium and phosphate in female rats. Intact 32 Sprague-Dawley female rats were divided into four groups (n=8): control, letrozole 0.2, letrozole 1 (treatment of 0.2 and 1 mg/kg for six weeks) and recovery (letrozole-treated 1 mg/kg for six weeks then allowed to recover for two weeks). Besides, 24 ovariectomized rats were divided into three groups (n=8): ovariectomized+control, ovariectomized+letrozole and ovariectomized+letrozole+ estradiol (10 mu g/rat). After experimental period, rats' femur bones were removed for biomechanical studies following decapitation. Serum ALP, calcium and phosphate were measured. Biomechanical values, ALP and phosphate significantly increased by letrozole in a dose-dependent manner (p<0.05) while calcium levels and net bone area decreased (p<0.05). Ultimate strength was positively correlated with ALP and phosphate and negatively correlated with calcium. The results indicate that letrozole may increase risk of bone fracture and affect bone biomarkers such as ALP, calcium and phosphate in both intact and ovariectomized rats.Öğe Evaluation of estrogenic effects of polychlorinated biphenyls and organochlorinated pesticides using immature rat uterotrophic assay(Sage Publications Ltd, 2013) Uslu, U.; Sandal, S.; Cumbul, A.; Yildiz, S.; Aydin, M.; Yilmaz, B.In this study, we investigated the effects of polychlorinated biphenyls (PCBs) and organochlorinated pesticides on the serum levels of luteinising hormone (LH), follicle stimulating hormone (FSH) and weights and histomorphometry of uterine tissue in immature female rats using uterotrophic assay. A total of 36 rats were randomly divided into six groups (n = 6 per group) as control, oestradiol (E-2, 100 mu g/kg), PCB 180, Aroclor 1221, endosulfan and mirex at 10 mg/kg dosage. After 3 days of injections (subcutaneous), animals were decapitated and blood samples were collected. Uteri were dissected, weighed out and then fixed in 10% formaldehyde. They were processed for histomorphometry. The serum levels of LH and FSH were determined by enzyme immunoassay. Uterine weight was significantly increased by E-2 and reduced by mirex (p < 0.001 and p < 0.05, respectively). Total volume of uterus was significantly raised by E-2, Aroclor 1221 and endosulfan compared with that of the control group (p < 0.01). The ratio of epithelium was significantly increased by E-2, PCBs and pesticides (p < 0.01). The uterine cavity ratio was decreased by aroclor (p < 0.01), PCB 180 and mirex (p < 0.05). The serum levels of LH did not significantly differ among the groups but the levels of FSH were decreased by PCB 180 and endosulfan (p < 0.05 and p < 0.01, respectively). These findings suggest that PCB 180, Aroclor 1221 and endosulfan may be estrogenic in immature uterotrophic assay.Öğe For how many times can a partially absorbable monofilament mesh be sterilized? In vitro experimental study(Springer Wien, 2013) Ozkan, O. V.; Aydogan, A.; Akkucuk, S.; Aydin, M.; Nacar, E.; Ozer, B.; Mistikoglu, S.We investigated the effects of hydrogen peroxide gas plasma resterilization (HPS) on partially absorbable monofilament meshes in terms of their mechanical properties and risk of infection. A mesh was divided into small pieces which were categorized as HPS-1, HPS-2 and HPS-3 according to the number of HPS. To assess the strength of specimens, maximum load, elongation at maximum load and quantity of energy required for complete failure of the specimens were measured. Microbiological and ultrastructural analyses were also performed. There was not a significant relationship between control and HPS-1, HPS-2 groups in terms of maximum load and quantity of energy required for complete failure of the specimens. However, those parameters were statistically different between HPS-3 and control groups. We observed minor morphological changes in the HPS-3 group when compared to those of the control group. No risk of infection was detected by microbiological tests. It is advisable to apply HPS to partially absorbable monofilament meshes no more than twice since sterilization for three times leads to degeneration in mesh structure and strength.Öğe The impact of irrigation water quality on water uptake by orange trees(Academic Journals, 2010) Yang, S. L.; Aydin, M.; Kitamura, Y.; Yano, T.A greenhouse lysimeter study was carried out in Tottori (Japan) during August 2000 to explore the impacts of saline irrigation on water uptake by orange trees. Two lysimeters filled with sandy soil were used. Each lysimeter was planted with a tree. During the first half of August, both lysimeters (L1 and L2) were irrigated with non-saline water. In the second half of the month, L1 was irrigated with non-saline water (1.0 dS/m) and L2 with saline water (8.6 dS/m). At each irrigation event, 60 and 32 mm water was applied in the first and second half of August, respectively, when average water content of the soil profile was depleted to 70% of field capacity. Osmotic potential in L2 became more negative after application of the saline water. Evapotranspiration from L1 was consistently higher than that from L2. Average transpiration rate (T) reached 5.5 mm/day under non-saline irrigation, while T was only 3.8 mm/day under saline treatment. Up to 99.5% of roots were in the top 60 cm of soil and 73% of the total water uptake was extracted from the same layer. Maximum water withdrawal by the tree was observed at layer of 30 - 60 cm in accordance with root-weight distribution.Öğe Protective effect of caffeic acid phenethyl ester on cyclosporine A-induced nephrotoxicity in rats(Elsevier Science Bv, 2009) Gokce, A.; Oktar, S.; Aydin, M.; Ilhan, S.; Yonden, Z.; Ozkan, O. V.; Davarci, M.[Abstract Not Available]Öğe Protective effects of caffeic acid phenethyl ester on iron-induced liver damage in rats(Springer, 2009) Oktar, S.; Yonden, Z.; Aydin, M.; Ilhan, S.; Alcin, E.; Ozturk, O. H.S. OKTAR, Z. YONDEN, M. AYDIN, S. ILHAN, E. ALCIN and O.H. OZTURK. Protective effects of caffeic acid phenethyl ester on iron-induced liver damage in rats. J Physiol Biochem, 65 (4), 339-344, 2009. Caffeic acid phenethyl ester (CAPE) is a natural product with potent anti-inflammatory, antitumor, and antioxidant activities, and attenuates inflammation and lipid peroxidation. The purpose of the present study was to investigate the effects of CAPE on iron-induced liver damage. Rats were divided into four groups and treated for 7 days with saline (control group), 10 mu mol kg CAPE/day s.c. (CAPE group), 50 mg iron-dextran/kg i.p. (IRON group) and CAPE and iron at the same time (IRON+CAPE group). Seven days later, rats were killed and the livers were excised for biochemical analysis. The administration of IRON alone resulted in higher myeloperoxidase (MPO) activity and lipid peroxidation than in the control and CAPE treatment prevented the increase in MPO activity and malondialdeyde (MDA) level. No differences were observed in all four groups with regards to superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities. Our results collectively suggest that CAPE may be an available agent to protect the liver from injury via inhibition of MPO activity.Öğe What is the relationship between type 2 diabetes mellitus and urolithiasis?(Comenius Univ, 2011) Davarci, M.; Helvaci, M. R.; Aydin, M.Aim: Despite the high incidence of urolithiasis in general population, the exact underlying pathology is unknown. Possible association between urolithiasis and parameters of physical health were assesed in the presented study. Material and methods: The study was performed at an Internal Medicine out patient unit during routine check ups. Patients between the ages of 20 and 70 years were studied to prevent debility induced weight loss in elderly. Patients with devastating illnesses were excluded to avoid their possible effects on weight. Cases with urolithiasis were collected in one group, and age and sex-matched cases without urolithiasis were collected in other group. Results: Eighty cases with urolithiasis and 120 cases without were studied. Mean age of urolithiasis cases was 49.0 years, and 52.5 % of them were female. Mean weight of the urolithiasis cases was 76.0 kg, whereas it was 80.8 kg in the group without urolithiasis (p=0.013). The prevalence of type 2 diabetes mellitus (DM) was significantly higher in the urolithiasis group with unknown reasons (17.5 % vs 7.5 %, p<0.01). There was no significant difference as for the height, body mass index, prevalence of hypertension, and mean values of low density lipoprotein cholesterol, high density lipoprotein cholesterol, and triglyceride between the groups. Conclusion: In spite of several terrible effects of excess weight on health, we could not detect any association with urolithiasis, but there is a highly significant association between urolithiasis and type 2 DM, and it may have hundreds of mechanisms with variable priorities, which must be explained with further studies (Tab. 1, Ref. 21). 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