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Öğe The Relationship Between the Neuron Density of the Trigeminal Ganglion and the Posterior Communicating Artery Vasospasm in Subarachnoid Hemorrhage: An Experimental Study(Lippincott Williams & Wilkins, 2012) Aydin, Mehmet Dumlu; Serarslan, Yurdal; Gundogdu, Cemal; Aydin, Nazan; Aygul, Recep; Kotan, Dilcan; Ulvi, HizirObjective: Posterior communicating arteries (PComAs) are innervated by vasodilatatory fibers of the trigeminal ganglion (TGG). We examined whether there is a relationship between the neuron density of the TGG and the severity of PComA vasospasm in a subarachnoid hemorrhage (SAH). Methods: This study was conducted on 20 rabbits. Five were used as a baseline control group. Five were used as a sham group by injecting 1 mL of serum physiologic, and experimental SAH was applied to 10 animals by injecting homologous blood into the cisterna magna. After 10 days, PComAs and TGGs were examined histopathologically. PComA volumes and the neuron density of TGGs were estimated stereologically, and the results were analyzed statistically. Results: In control group, the mean volume of the PComAs was 66,500 +/- 8500 mu m(3), and the mean neuronal density of the TGGs was 8650 +/- 950/mm(3). In the serum physiologic group, the mean volume of the PComAs was 65,000 +/- 6550 mu m(3), and the mean neuronal density of the TGGs was 8600 +/- 800/mm(3). In the SAH group, the mean volume of the PComAs was 46,500 +/- 5500 mu m(3), and the mean neuronal density of the TGGs was 4200 +/- 500/mm(3). The results reveal an inverse relationship between the neuronal density in the TGG and the severity of the PComA vasospasm. Conclusions: The neuron density of the TGG may be an important factor in the regulation of PComA volume and in the continuation of cerebral blood flow. Low neuron density in the TGG may play an important role in the pathogenesis of PComA vasospasm in SAH.Öğe The Role of Trigeminal Ganglion Neuron Density in the Prevention of Subarachnoid Hemorrhage-induced Basilar Artery Vasospasm: An Experimental Study(Lippincott Williams & Wilkins, 2009) Onder, Arif; Serarslan, Yurdal; Aydin, Mehmet Dumlu; Aydin, Nazan; Ulvi, Hizir; Kotan, Dilcan; Aygul, RecepObjective: Cerebral arteries innervated by several systems contribute to the control of cerebral blood flow. Sensory fibers of the trigeminal nerve have a vasodilatory effect on the basilar artery. Subarachnoid hemorrhage (SAH) causes severe cerebral vasospasm by various neurochemical mechanisms. We examined possible relationships between the neuron density of the trigeminal ganglion and the severity of basilar artery vasospasm in SAH. Methods: In this study, 28 rabbits were used. The animals were randomly divided into 3 groups: SAH (n = 18), serum physiologic (n = 5) and control (n = 5) groups. Experimental SAH was induced by injecting homologous blood into the cisterna magna. After 20 days, the basilar arteries and trigeminal ganglions were examined histopathologically. Basilar artery volumes and the neuron density of the ophthalmic divisions of the trigeminal ganglions were estimated stereologically, and the results were statistically analyzed. Results: The mean basilar artery volume was 4.15 +/- 0.19 mm(3) and the mean neuronal density of the trigeminal ganglion was 6500 +/- 750/mm(3) for the control group. These values were 4.05 +/- 0.29 mm(3) and 6400 +/- 584/mm(3) for the serum physiologic group, 3.80 +/- 0.35 mm(3) and 4600 +/- 300/mm(3) for living animals in the SAH group, and 2.26 +/- 0.29 mm(3) and 2950 +/- 618/mm(3) for dead animals in SAH group, respectively. A linear relationship was found between the neuronal density of the trigeminal ganglion and basilar artery volumes. Conclusions: The neuron density of the trigeminal ganglion may be an important factor in the regulation of basilar artery volume and for the continuation of cerebral blood flow. The low neuron density of the trigeminal ganglion may be involved in the pathogenesis of severe basilar artery vasospasm induced by SAH.Öğe Taste bud-like structures in penile tissues and a predictive neural mechanism of male orgasm: A preliminary hypothesis based on histological evidence(Elsevier, 2014) Aydin, Mehmet Dumlu; Aydin, Nazan; Dane, Şenol; Gündo?du, Cemal; Gürsan, Nesrin; Akçay, Fatih; Serarslan, YurdalThe basic mechanism of orgasmic pleasure has not yet been elucidated, although there is a broad similarity between taste and orgasmic sensation. Taste buds of the tongue stimulated by tastants have been well described, and taste information has been established as an important regulator of food selection and nutrition. However, very little is known regarding how pleasure sensation is created and perceived in an orgasm. Thus, we investigated whether there were taste bud-like structures stimulated by seminal fructose in the male urethra and glans penis. To confirm this hypothesis, we examined the urethral tissues of 22 male rabbits using modern histological techniques. We discovered that the male urethra and glans penis contained many taste bud-like structures similar to the morphological features of the taste buds of the tongue. Interestingly, these taste bud-like structures resembling those of the tongue were detected in the intramural openings of the urethral lacunae and glandular surfaces. These structures have neuron-like appendages at the apical ends of rose buds in the wall of the urethra and glans. Moreover, each urethral plica contained some taste buds that were particularly more dense in the distal urethra and glans penis. We hypothesized that the pelvic autonomous nerves innervated both the urethral and glans taste buds and conveyed orgasmic sensation from the urethral taste buds to the taste information-computing centers in the brain. We postulated that urethral taste buds are stimulated by seminal fructose, and supplying nerves may play a predominant role in the creation of orgasmic sensation, which has not yet been well studied thus far. © 2014 Elsevier GmbH. All rights reserved.
