Yazar "Aydogan, Fusun" seçeneğine göre listele
Listeleniyor 1 - 11 / 11
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Ductal Adenocarcinoma: A Rare Entity of Prostate Gland in a Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Patient(Derman Medical Publ, 2015) Ozgur, Tumay; Rifaioglu, Murat Mehmet; Sumbul, Ahmet Taner; Aydogan, Fusun; Atci, NesrinProstate cancer is the most common malignancy in men and ductal adenocarcinoma is a pathologic subtype with specific histological and clinical features. Seventy-six year-old male patient with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) admitted to our hospital with lower urinary tract symptoms. The last prostate specific antigen (PSA) level was 26 ng/ml and serial transrectal ultrasound guided biopsies were administered and benign prostate hyperplasia and non-specific prostatitis were the results of pathology reports. Due to the persistence of the symptoms transurethral resection of the prostate was performed. In the pathologic evaluation of the material adenocarcinoma focuses without stroma has been observed between the hyperplasic prostate tissues. The tumor has been diagnosed as ductal adenocarcinoma with 4 + 4 Gleason pattern score. Bone scintigraphy was revealed activity uptake on lomber vertebral column due to metastasis. Computerized tomography was revealed previous bilateral inguinal and right iliac lymphadenopathy due to CLL/SLL. Total androgen deprivation therapy and bilateral orchiectomy was applied. After three mounts according to biochemical and imaging results, radiotherapy cure began. Ductal adenocarcinoma is a rare subtype of prostate carcinoma with clinical behavior from that seen in conventional adenocarcinoma. On the other hand it is worth to point out the occurence of this entity as second malignancy during follow-up of CLL/SLL.Öğe Effect of Radioactive Iodine Therapy on Lacrimal Gland Functions in Patients With Hyperthyroidism(Lippincott Williams & Wilkins, 2014) Aydogan, Fusun; Tuzcu, Esra Ayhan; Aydogan, Akin; Akkucuk, Seckin; Coskun, Mesut; Ustun, Ihsan; Gokce, CumaliBackground Radioactive iodine (RAI) therapy is preferred in the treatment of hyperthyroidism because of its effectiveness, noninvasiveness, and low costs. I-131 has been detected in extrathyroidal tissues, such as in gastric mucosa, salivary glands, and lacrimal glands. To the best of our knowledge, there is no publication concerning the effects of RAI therapy for hyperthyroidism on tear production. In the present study, we evaluated whether or not the lacrimal glands are affected after RAI therapy when compared with pretreatment period. Methods The Schirmer and tear break-up time (TBUT) tests were used to assess 32 eyes of 16 patients with conditions that were diagnosed as hyperthyroidism before and at 3 and 6 months after RAI treatment. In addition, pretreatment values of patients were compared with that of controls. It was evaluated whether or not a correlation exists between the results and the dose or iodine uptake values. Results There was no significant difference between pretreatment values of Schirmer and TBUT tests obtained in the patient group and those of the control group (P > 0.05). In the patient group, there was a significant difference between the posttreatment and pretreatment values (P < 0.05). There was a positive correlation between uptake values obtained at 24 hours and the values obtained by TBUT and Schirmer tests on both eyes at 3 and 6 months. At 6 months, the uptake value at 24 hours was 28.83 +/- 60 for both eyes in patients with TBUT test values less than 10, whereas it was 39.25 +/- 7.88 for the right eye and 39.00 +/- 6.85 for the left eyes in patients with TBUT test values greater than 10. The difference was statistically significant (P < 0.05). Conclusions In our study, we concluded that the decrease in mucin and aqueous production occurs due to affected lacrimal glands by RAI therapy; however, this effect is not dose dependent.Öğe Effect of short term thyroxin withdrawal on health related quality of life in differentiated thyroid carcinoma patients(In House Publications, 2015) Elboga, Umut; Elboga, Gülçin; Kalender, Ebuzer; Demir, Hasan Deniz; Sahin, Ertan; Basibuyuk, Mustafa; Aydogan, FusunBackground: We aimed to study the HRQL in patients with differentiated thyroid carcinoma (DTC) during hypothyroidism due to thyroxin withdrawal, which is induced routinely for iodine-131 (I-131) whole body scan and ablative treatment. Methods: Between September 2011 and March 2012, eligible patients with DTC who were referred to our institution for diagnostic or therapeutic radioiodine administration under hypothyroid conditions due to thyroid hormone withdrawal were asked to complete the psychological instruments rating their HRQL and psychological status. HRQL was studied using the Short Form (SF-36), Hospital Anxiety and Depression Scale (HADS), Profile of Mood States (POMS), the total mood disturbance (TMD) score, Beck Depression Inventory (BDI).One hundred and forty three hypothyroid patients with DTC (F=101, M=42, age=58.7 yrs) who were also on low-iodine diet were included in this study. Hypothyroidism was induced by withdrawal of thyroxin replacement in all patients. Results: The results of SF-36 showed that the HRQL was significantly impaired in hypothyroid patients during withdrawal of thyroxin (physical component scale: 44.3 ± 9.5, mental component scale: 40.8 ± 10.2, p ? 0.001). Depression scores were in the normal or non-clinically relevant range: 4.1 ± 3.8 on the HADS-Depression and 8.3 ± 6.6 on the Beck Depression Index. However, the mean score of 28.8 ± 25.2 on the POMS TMD was within normal range. Conclusion: HRQL is impaired in hypothyroid patients with DTC during thyroxine withdrawal before I-131 whole body scan and radioiodine therapy. © 2015 Elboga U, et al.Öğe Investigation of the association between glaucoma and Helicobacter pylori infection using the 14C-urea breath test(Consel Brasil Oftalmologia, 2015) Tuzcu, Esra Ayhan; Aydogan, Fusun; Motor, Vicdan Koksaldi; Ilhan, Ozgur; Daglioglu, Mutlu Cihan; Coskun, Mesut; Ikirer, Nihan ParlakfPurpose: To investigate the association between glaucoma and Helicobacter pylori infection by evaluating for the presence of H. pylori infection in patients with glaucoma using the C-14-urea breath test (14C-UBT). Methods: Using 14C-UBT, H. pylori infection positivity was compared between a group of patients with primary open-angle glaucoma and a control group with normal intraocular pressure and a normal optic disc or normal perimetry. Results: The 14C-UBT was positive in 18 (51.42%) out of 35 patients in the glaucoma group and in 15 (42.85%) out of 35 patients in the control group. H. pylori infection positivity rates were similar between the glaucoma and control groups (p>0.05). Conclusion: According to the 14C-UBT, there is no association between primary open-angle glaucoma and H. pylori infection.Öğe Orbital compression syndrome complicated by epidural hematoma and wide cephalohematoma in a patient with sickle cell disease(Mosby-Elsevier, 2014) Ilhan, Nilufer; Acipayam, Can; Aydogan, Fusun; Atci, Nesrin; Ilhan, Ozgur; Coskun, Mesut; Daglioglu, Mutlu CihanOrbital wall infarctions resulting in orbital and epidural hematomas are rare manifestations of sickle cell disease (SCD). We report orbital compression syndrome associated with an epidural hematoma and wide cephalohematoma in a 15-year-old boy with SCD. An infarcted orbital bone was observed on magnetic resonance imaging and three-phase bone scintigraphy with Technetium-99m methylene diphosphonate. The patient recovered completely without surgical intervention at the end of the fourth week. Prompt diagnosis and proper management are critical for complete recovery.Öğe Orbitomaxillomandibular Reconstruction With Free Osteomyocutaneous Fibular Flap and Lower Trapezius Myocutaneous Flap(Lippincott Williams & Wilkins, 2013) Akbay, Ercan; Aydogan, Fusun; Ucak, MuratSeveral types of flaps and techniques have been used in the reconstruction of maxillomandibular defects. Myocutaneous flaps of the fibula, the scapula, the rib, the iliac bone, the radial forearm, the rectus abdominis, the anterolateral thigh, the latissimus dorsi, and the pectoralis major have been used either alone or in combination for this purpose. The aim of the current study was to discuss a 17-year-old patient with a gunshot injury who underwent orbitomaxillomandibular bone reconstruction using free fibular graft shaped as 3 pieces and soft tissue reconstruction using lower trapezius myocutaneous flap in conjunction with the surgical approach used.Öğe Platelet and white blood cells in severity of sickle cell diseases(Prensa Medica Argentina, 2014) Helvaci, Mehmet Rami; Aydogan, Fusun; Sevinc, Alper; Camci, Celaletdin; Dilek, ImdatBackground: We tried to understand whether or not there is an association between platelet (PLT) and white blood cell (WBC) counts of peripheric blood and severity of sickle cell diseases (SCDs). Methods: The SCDs patients with red blood cell transfusions of less than 50 units in their lives were put into the first and 50 units or higher were put into the second groups. Results: The study included 316 cases. There were 224 cases (70.8%) in the first and 92 cases (29.1%) in the second groups (p<0.001). Male ratio was significantly higher in the second group (45.5% versus 64.1%, respectively, p<0.001). Although both the WBC and PLT counts were higher in the second group, the difference was only significant for the PLT counts (p= 0.005) probably due to the small sample sizes. Although prevalences of smoking, avascular necrosis of bones, cirrhosis, and exitus were similar in the groups, mean number of painful crises per year, digital clubbing, chronic obstructive pulmonary disease, leg ulcers, stroke, chronic renal disease, and coronary heart disease were significantly higher in the second group (p<0.05 for all). Conclusion: Although the difference was statistically nonsignificant between the WBC count and severity of SCDs probably due to the small sample sizes of the study, there was a highly significant association between the PLT count and disease severity. So the higher PLT and WBC counts of the second group may indicate the significant roles of the cells for the chronic endothelial damage of the SCDs all over the body.Öğe Reconstruction of isolated mandibular bone defects with non-vascularized corticocancellous bone autograft and graft viability(Elsevier Sci Ltd, 2014) Akbay, Ercan; Aydogan, FusunObjective: The aim of this study is to discuss the use of non-vascularized bone grafts in mandibular reconstruction and their viability. Methods: In this study, 11 patients with mandibular defect treated by surgery using non-vascularized bone grafts between 2011 and 2012 were reviewed. All patients underwent preoperative and postoperative 3-dimensional computerized tomography scan for surgical planning and evaluation of success after surgery. Grafts were used for defects caused by mandible tumors in 2 patients and firearm injuries in 9 patients. Reconstruction was achieved by using various non-vascularized bones, including iliac crest, fibula and scapula. To improve graft supply, periosteum of the grafts was spared and multiple bores were created on the graft during surgery by drilling. At the postoperative period, Dextran 70 and Bencyclane Hydrogen Fumarate was given in order to enhance micro-circulation. On the postoperative day 5, 15 and 30, Tc-99 m methylenediphosphonate scintigraph, blood-pool single photon emission computed tomography and it's bone phase were performed in order to assess viability of bone grafts greater than 3 cm. Results: Mean age was 32.27 +/- 13.33 (min = 10-max = 56). Of the 11 patients, 10 (90.9%) were men and 1 (9.1%) was woman. Mandibular defects were at right corpus in 3 patients; at right ramus and angulus in 1 patient; at left corpus in 1 patient; at left ramus and angulus in 1 patient; at left ramus, angulus and corpus in 1 patient; left parasymphysis in I patient; at bilateral corpus in 1 patient; at symphysis in 1 patient and at whole segment from right corpus to left one in 1 patient. The following grafts were used: iliac crest grafts in 9 cases, scapula graft in 1 case and fibula graft in 1 case. The smallest graft used was 1 x 2 cm in size, while the greatest, single piece graft was 7 cm in size. The greatest multi-piece graft was a fibula graft of 14 cm in length. All grafts with a size of 3 and 7 cm had been supplied at the end of first month. No bone resorption or donor site morbidity was observed in any patient. Conclusion: Non-vascular bone grafts can be successfully used in isolated bone defects of mandible in case of appropriate graft selection for fitting anatomical region. A single piece iliac crest grafts up to 7 cm can be revascularized in long-term. (C) 2013 Elsevier Ireland Ltd. All rights reserved.Öğe Regional Distributions of Distant Metastases Detected in Differentiated Thyroid Cancers(Derman Medical Publ, 2015) Kalender, Ebuzer; Elboga, Umut; Aydogan, Fusun; Basibuyuk, Mustafa; Demir, Hasan Deniz; Sahin, Ertan; Celen, Y. ZekiAim: The aim of our multicenter study is to determine retrospectively the regional distributions of distant metastases which are detected in differentiated thyroid cancers (DTC). Material and Method:Thirty-two of 960 patients with distant metastases who were given radioiodine (RAI) treatment in Gaziantep University School of Medicine and Mustafa Kemal University School of Medicine were included to study. Six of patients were male, 26 of them were female. Mean age was 52 15.4. Hystopathological diagnoses were reported as papillary thyroid cancer in 23 patients and folliculary thyroid cancer in 9 patients. The distant metastasis ratio, metastasis regions and distributions were determined. Results: It was observed only lung metastasis in 18 (56.25 b), only bone metastasis in 6 (18.75 To), combination of lung and bone metastases in 3 (9.4 %), other organ metastases accompanying to bone and lung metastases in 5 (9.4 %) (liver, soft tissue, mediastinum) and multipl organ involvoment in 2 (6.2 96) of patients. It was determined single metastasis region in 24 (75 To), 2 metastasis regions in 6 (18.75 glo) and multipl metastasis regions in 2 (6.25 WO of patients. Discussion: Distant metastases are the biggest problem in treatment and follow-up of DTCs. It is very important to diagnosis of metastases and determine the regions of involvoment in these patients.Öğe Retrospective Analysis of Indication of Bone Scintigraphy Performed in Our Clinic(Derman Medical Publ, 2015) Aydogan, Fusun; Kalender, Ebuzer; Dokuyucu, RecepAim: Bone scintigraphy is one of the commonly used radionuclide imaging and it is successfully used in the diagnosis and follow-up of many diseases. The aim of this study is to determine the indications and filming protocols of bone scintigraphy which was performed in our clinic. Material and Method: Two hundred and fifty two patients (132 male, 120 female) who was performed bone scintigprapy in our clinic between December 2011 and June 2013 included the study. Mean age was 50.1 +/- 20.2 years. Scintigraphic protocols were made in two ways as late static whole body imaging and three-phase bone scintigraphy according to the type of the diseases. Indications of scintigraphies and scintigraphic protocols were detected. Results: Bone scintigraphy was performed for diagnosis and monitoring of metastatic bone disease to 102 patients (40,5 %), for orthopedic applications to 57 patients (22,6 %), for diagnosis and monitoring of primary bone tumors to 29 patients (11,5 %), for diagnosis of osteomyelitis to 17 patients (6,7 %), for differential diagnosis of infection and loosening of the prosthesis to 12 patients (4,8 %), investigate the viability of the graft in 14 patients (4,6 %), for rheumatologic diseases to 9 patients (3,6 %), for investigate the pathological vertebral fractures and osteoporosis to 4 patients (1,6 %), for diagnosis the metabolic bone disease to 2 patients (0,8 %), for diagnosis of otitis externa to 5 patients (1,98 %) and for for suspicion of malignancy to 1 patient (0,4 %). Late static whole body imaging protocol was applied to 136 patients (54 %) and three-phase imaging protocol was applied to 116 patients (46 %). Discussion: The most common use of bone scintigraphy is the diagnosis and follow-up of metastatic bone disease. It is followed by reasons such as orthopedic applications, monitoring and diagnosis of primary bone tumors and diagnosis of osteomyelitis.Öğe Thyroid Hemiagenesis, Ectopic Submandibular Thyroid Tissue, and Apparent Persistent Subclinical Thyrotoxicosis(Mary Ann Liebert Inc, 2013) Aydogan, Fusun; Aydogan, Akin; Akkucuk, Seckin; Ustun, Ihsan; Gokce, CumaliBackground: Ectopic thyroid tissue (ETT) is a rare embryological abnormality characterized by the occurrence of thyroid tissue in a site other than its usual location. Thyroid hemiagenesis (HA) is also a very rare abnormality in which one thyroid lobe does not develop properly during embryology. We report a patient with left HA, submandibular ETT, and persistent mildly suppressed serum thyrotropin (TSH). Patient: A 38-year-old female patient was admitted with complaints of sweating and palpitations. She had no symptoms of neck compression. Thyroid ultrasonography revealed heterogeneity and hypoechogenicity of the right lobe and absence of the left lobe, the latter being confirmed by computed tomography. There was no ETT in the neck. A thyroid Tc-99m pertechnetate scan demonstrated two distinct areas of radiotracer uptake, one in the right lobe of the thyroid gland and one in the right submandibular region and lobe, but no uptake in the left thyroid bed. The serum free triiodothyronine was 2.89 pg/mL (2.5-3.9 pg/mL), and the serum free thyroxine was 0.86 ng/dL (0.61-1.12 ng/mL). The serum TSH was 0.11 mIU/L (0.34-5.60 mIU/L). Conclusions: This may be the first reported patient with HA and submandibular ETT. The patient probably also had thyroiditis with mild intermittent thyrotoxicosis based on her suppressed TSH and ultrasonography imaging of the right thyroid lobe.
