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A Case of Chemical Ventriculitis Due to Intraventricular Colistin Treatment
(Derman Medical Publ, 2014) Dorum, Bayram Ali; Bal, Tayibe; Ozer, Utku; Aygun, Fatma Deniz; Silfeler, Ibrahim
Nosocomial infections of central nervous system have high mortality, if they are due to Acinetobacter spp., the rate can be as high as 70%. Intraventricular treatment of ventriculitis, caused by Acinetobacter baumannii can be considered as current treatment choice, because of this high mortality. Here in, we report a case of ventriculitis, caused by A. baumannii related to ventriculoperitoneal shunt. We used to treat both with intravenous meropenem, colistin, rifampicin and intraventricular colistin and gentamcin because of persistent ventriculitis after removel of the shunt and multi drug resistant blood flow infection of A. baumannii. The culture of cerebrospinal fluid (CSF) became sterile with intraventricular treatment, but pleocytosis, fever and low glucose level of CSF persisted and chemical ventriculitis was considered to become. We continued the treatment with decreasing the dosage and increasing the interval of drug and were successful both in treatment of the infectious and chemical ventriculitis. The aim of this article is to report the successful treatment of ventriculitis caused by A. baumannii with intraventricular colistin in the fail of intravenous treatment, despite of reversible chemical ventriculitis.