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    EFFICIENCY OF PROPOFOL CO-ADMINISTERED WITH REMIFENTANIL AND FENTANYL OVER LARYNGEAL MASK AIRWAY INSERTION
    (Soc Stinte Farmaceutice Romania, 2017) Urfali, Senem; Aykut, Buket Cagla Ozbakis
    In this study we assessed and compared the conditions during insertion of the Laryngeal Mask Airway (LMA) to patients undergoing minor surgery, who received either remifentanil, fentanyl, or normal saline co-administered with propofol. Ninety patients with American Society of Anesthesiology (ASA) class-I/II aged from 18 to 60 years undergoing minor surgery were included in this prospective study. Patients were randomly allocated to receive either normal saline (Group I), fentanyl 1 mu g/kg (Group II), or remifentanil 1 mu g/kg (Group III) over 30 s following induction of anaesthesia with propofol 2.5 mu g/kg + lidocaine 1 mu g/kg. LMA insertion conditions including mouth opening, ease of placement, coughing, swallowing, laryngospasm, airway obstruction and patients' movement were assessed. Time to eyelash reflex loss, time to successfully place LMA, number of attempts and haemodynamic variables were also recorded. Demographic data were all similar between the groups. Heart rate and blood pressure values were lower in remifentanil and fentanyl groups in comparison with the saline group. Induction rates were found to be the highest in the remifentanil group, followed by fentanyl and saline groups. Both remifentanil and fentanyl increased the LMA insertion tolerance when co-administered with propofol, with remifentanil producing slightly better conditions.
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    Efficiency of propofol co-administered with remifentanil and fentanyl over laryngeal mask airway insertion
    (Romanian Society for Pharmaceutical Sciences, 2017) Urfali, Senem; Aykut, Buket Cagla Ozbakis
    In this study we assessed and compared the conditions during insertion of the Laryngeal Mask Airway (LMA) to patients undergoing minor surgery, who received either remifentanil, fentanyl, or normal saline co-administered with propofol. Ninety patients with American Society of Anesthesiology (ASA) class-I/II aged from 18 to 60 years undergoing minor surgery were included in this prospective study. Patients were randomly allocated to receive either normal saline (Group I), fentanyl 1?g/kg (Group II), or remifentanil 1 ?g/kg (Group III) over 30 s following induction of anaesthesia with propofol 2.5 ?g/kg + lidocaine 1 ?g/kg. LMA insertion conditions including mouth opening, ease of placement, coughing, swallowing, laryngospasm, airway obstruction and patients’ movement were assessed. Time to eyelash reflex loss, time to successfully place LMA, number of attempts and haemodynamic variables were also recorded. Demographic data were all similar between the groups. Heart rate and blood pressure values were lower in remifentanil and fentanyl groups in comparison with the saline group. Induction rates were found to be the highest in the remifentanil group, followed by fentanyl and saline groups. Both remifentanil and fentanyl increased the LMA insertion tolerance when co-administered with propofol, with remifentanil producing slightly better conditions. © 2017, Romanian Society for Pharmaceutical Sciences. All Rights reserved.