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    Öğe
    Cannabinoid receptor 1 (CNR1) gene polymorphisms in schizophrenia patients: Rs6454674 polymorphism is associated with disease severity
    (2015) Çöpoğlu, Ümit Sertan; Iğci, Mehri; Bozgeyik, Esra; Kokaçya, Mehmet Hanifi; Iğci, Yusuf Ziya; Özden, Aslan; Bülbül, Feridun; Alpak, Gökay; Arı, Mustafa; Savaş, Haluk Asuman
    Objective: The endocannabinoid system contributes to the regulation of emotions, stress, memory, and cognition. It has been reported that endocannabinoids cause GABAergic inhibition and dopaminergic increase in the mesolimbic and nigrostriatal systems, thus playing a part in the neurobiology of schizophrenia. In this study, we investigate cannabinoid receptor 1 (CNR1) gene polymorphisms in schizophrenia patients. Methods: CNR1 gene polymorphisms were studied in 66 schizophrenia patients and 65 healthy controls. To obtain genomic DNA, proteinase K digestion and the salt-chloroform method were used. Clinical Global Impression severity scale (CGI-S) and Positive and Negative Syndrome Scale (PANSS) were administered to evaluate the severity of schizophrenia symptoms. CNR1 gene polymorphism was determined by using polymerase chain reaction (PCR), Restriction Fragment Length Polymorphism (RFLP), and Single Strand Conformation Polymorphism (SSCP) methods for the Rs6454674, Rs806368, and Rs1049353 sites.Results: There was no difference in CNR1 gene polymorphisms between schizophrenia patients and control groups (Rs6454674 T/G; p=0.973, Rs806368 T/C; p=0.349, Rs1049353 A/G; p=1.00). However, CGI-S, PANSS total, PANSS positive, PANSS negative and PANSS general psychopathology scores were significantly lower in schizophrenia patients with RS6454674 polymorphism than in those not showing polymorphism. Conclusion: Our results suggest that CNR1 gene polymorphisms may be associated with clinical symptoms and disease severity in schizophrenia patients
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    Öğe
    Evaluation of psychiatric diagnosis, substance use situations, sociodemographic and clinical features of cases in forensic psychiatry unit
    (Istanbul Universitesi, 2014) Çöpoglu, Ümit Sertan; Bülbül, Feridun; Hanifi Kokaçya, M.; Alici, Demet; Tastan, Mehmet Fatih; Ünal, Ahmet; Alpak, Gökay
    Objectives: The aim of the study is to investigate the diagnosis, substance use situations, sociodemographic and clinical features of cases referred from forensic medicine to our forensic psychiatry clinic. Method: In this study archive files and reports of 412 cases referred from forensic medicine to Gaziantep University Faculty of Medicine Forensic Psychiatry Clinic between 2007-2011 years were investigated retrospectively. Results: Cases in which substance use and dependence were evaluated, cannabis was found to be 57.1%, heroin 14.6%, multiple substances 13.1% and drug 0.5%. Cases that were evaluated with regards to TCK 32, multiple substances were found to be 7.7%, cannabis 6.9%, and heroin 3.8%. Male sex was found to be significantly higher and educational levels were found to be significantly lower in cases in terms of crime, substance use and dependence and evaluated for criminal liability. In our study, cases involved in crime, had the psychiatric diagnoses in order of frequency as substance dependence, psychotic disorders and mood disorders. Discussion: People with substance use and dependence are too much involved in crime directlyor indirectly depending upon the substance use. These people are frequently enrolled in the judicial system and in this process they are subjects of forensic psychiatry. © 2014, Istanbul Universitesi. All rights reserved.