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  • Küçük Resim
    Öğe
    Benin, premalin ve malin lezyonlarda hücre proliferasyon belirleyicilerinin ekspresyonu ve insan papilloma virus izolasyonu
    (2007) Serarslan, Gamze; Atik, Esin; Otlu, Barış; Bakariş, Sevgi; Durmaz, Rıza
    AMAÇ: Bu çalışmada çeşitli benin, premalin ve malin deri lezyonlarında proliferasyon belirleyicilerinin rolü ve bu lezyonlarda insan papilloma virusu (HPV) pozitifliğinin saptanması amaçlandı. GEREÇ-YÖNTEM: Çalışmaya, parafin bloktaki 62 doku [12 seboreik keratoz (SK), 10 keratoakantom (KA), 8 aktinik keratoz (AK), 22 bazal hücreli karsinom (BHK) ve 10 skuamöz hücreli karsinom (SHK)] alındı. Doku örnekleri, Ki-67, p21 ve bcl-2 ekspresyonunu belirlemek amacıyla, immünohistokimyasal yöntemle çalışıldı. HPV DNA’sını tespit etmek için PCR uygulandı. BULGULAR: BHK tanısı almış olan iki dokuda HPV (tip-16) pozitifliği saptandı. Lezyonlarda Ki-67, p21 ve bcl-2 ekspresyonu sırası ile şu şekildeydi: KA
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    Öğe
    Expression of cell proliferation markers in benign, premalignant and malignant lesions and human papillomavirus isolation
    (2007) Serarslan, Gamze; Atik, Esin; Otlu, Bariş; Bakariş, Sevgi; Durmaz, Riza
    Background and Design: This study was designed to investigate the role of proliferation markers in various benign, premalignant and malignant skin lesions and also aimed to detect HPV positivity in these lesions. Material and Method: A total of 62 paraffin blocks [12 seborrheic keratoses (SK), 10 keratoacantoma (KA), 8 actinic keratoses (AK), 22 basal cell carcinoma (BCC), and 10 squamous cell carcinoma (SCC)] were included in the study. Specimens were studied immunohistochemically for the expression of Ki-67, p21 and bcl-2. PCR was performed to detect HPV DNA. Results: HPV positivity was detected in two tissues of BCC (HPV type-16). In the lesions, the Ki-67, p21 and bcl-2 expressions were found to be increased respectively: KA
  • Küçük Resim
    Öğe
    The importance of proliferative activity and angiogenesis in meningioma and glioma
    (Turkish Neurosurgical Society, 2005) Atik, Esin; Serarslan, Yurdal; Bakariş, Sevgi; Savaş, Nazan
    OBJECTIVE: The aim of this study was to investigate the usefulness of a mean vascular density (MVD) and proliferative activity labeling index (LI) in gliomas and meningiomas as biological markers in histological grading. MATERIALS AND METHODS: Our study included 18 cases of glioma and 36 cases of meningioma. These cases were graded according to the WHO classification. CD-34 and Ki-67 immunohistochemical methods were used on paraffin-embedded tissues. Distribution of CD-34 and Ki-67 LI values were determined for different histologic grades of gliomas and meningiomas. The results were analyzed with statistical methods. RESULTS: In gliomas, the values of Ki-67 were detected as 3.33±2.50 in grade I, 5.01±2.28 in grade III and 10.33±4.85 in grade IV. The mean values of CD-34 were found as 11.80± 9.71 in grade III glioma and 8.40±5.45 in grade IV glioma. The values of Ki-67 were detected as 4.40±0.40 in atypical, 4.26±4.05 in psammomatous and 3.69±3.24 in meningothelial meningioma. CD-34 expression was 19.60±0.20 in angiomatous meningioma and 6.14±1.91 in malignant meningioma. CONCLUSION: Our results show that Ki-67 LI and angiogenesis can be useful in tumor grading of gliomas. However, the score of angiogenesis and Ki-67 LI adds little information to predict tumor grade in meningiomas, in contrast to gliomas.