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Öğe Effects of lead on lipid peroxidation in rabbits(Indian Veterinary Journal, 2004) Celik, S; Bal, R; Yarsan, E; Durgut, RExperimental evidence suggests that the cellular damage medicated by free radicals can be involved in the pathology associated with lead intoxication. In the erythrocytes of workers exposed occupationally to lead, significant increase in the activities of the antioxident enzymes was reported (Sugawara et al., 1991; Bechara et al., 1993; Skoczynska et al., 1993; Jiun and Hsien, 1994; Skoczynska and Smolik, 1994). The aim of this study was to evaluate the effects of lead at doses of 80 and 160 mg kg(-1) body weight on lipid peroxidation in six-month old New Zealand rabbits.Öğe Efficacy of tribasic copper chloride (TBCC) to reduce the harmful effects of aflatoxin in broilers(Tubitak Scientific & Technological Research Council Turkey, 2005) Çelík, S; Erdogan, Z; Erdogan, S; Bal, RThis study was conducted to evaluate the effects of copper as tribasic copper chloride on serum biochemical values and growth performance of broilers intoxicated with aflatoxins. Aflatoxins significantly decreased the level of albumin (P < 0.001), total protein (P < 0.001) and total cholesterol (P < 0.01), and increased the activities of alanine amino transferase, L-lactic dehydrogenase and alkaline phosphatase (P <= 0.001) in serum. These AF-induced changes were significantly improved by adding tribasic copper chloride to the diet. The decrease in serum copper concentration induced by aflatoxin was reversed by tribasic copper chloride. Serum zinc concentrations were not affected in tribasic copper chloride and tribasic copper chloride plus aflatoxin groups. Serum iron levels decreased in all the treatment groups significantly (P < 0.05). Aflatoxins caused significant decrease in the body weight gain and significant increase in the feed conversion ratio. Adverse effects of aflatoxins on feed conversion ratio were reversed by tribasic copper chloride supplementation to the diet. It is suggested that tribasic copper chloride might be used for reducing the adverse effects of aflatoxins in broiler production.Öğe Experimental hyperkalaemia in rabbits: Effects of salbutamol and norepinephrine treatments on blood biochemistry and electrocardiography(Akademiai Kiado, 2003) Celik, S; Bal, R; Durgut, RThe effects of salbutamol and norepinephrine on the electrocardiogram (ECG), serum potassium level and enzyme activities were studied in rabbits with hyperkalaemia; norepinephrine and salbutamol may be therapeutically useful. For induction of hyperkalaemia, 300 mM KCl solution was used and then isotonic saline solution containing 6 mug salbutamol and 3.9 mug norepinephrine per ml were administered. Norepinephrine and salbutamol decreased the serum potassium from 7.36 +/- 0.26 and 7.21 +/- 0.31 mmol/L to 5.62 +/- 0.27 and 4.35 +/- 0.33 mmol/L, respectively, and caused the ECG changes (flatness of P wave, widening of QRS complex and bradycardia) to return to the control conditions (time 0). Norepinephrine, but not salbutamol, decreased the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) to the control levels. These results suggest that monitoring of the enzyme activities might be useful as it yields indexes suitable for evaluating the therapeutic approach with norepinephrine in hyperkalaemia.Öğe Firing patterns of inferior colliculus neurons-histology and mechanism to change firing patterns in rat brain slices(Elsevier Sci Ireland Ltd, 2002) Bal, R; Green, GGR; Rees, A; Sanders, DJAn in vitro slice preparation was used for intracellular recording from rat central nucleus of inferior colliculus neurons (CNIC). Stable intracellular recordings were made on 184 neurons, 27 of which were successfully stained with ionto-phoresed biocytin. Twenty one of those were classified as flat (F), four as less flat (LF) and the remaining two neurons as unclassified neurons. Recording in response to depolarizing current steps revealed five firing patterns: onset, adapting (regularly and irregularly), regular and bursting. The onset neurons showed non-linear current-voltage (I-V) relationship, whereas the rest had linear current-voltage relationship. Preconditioning hyperpolarizations changed the response pattern of CNIC neurons. It is concluded that there is no anatomy and physiology correlation and the levels of membrane potential may be important in the production of some firing patterns. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.Öğe Subclinical fatty liver syndrome in Damascus goats(Indian Veterinary Journal, 2003) Gonenci, R; Durgut, R; Erdogan, S; Bal, R; Celik, S[Abstract Not Available]
