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Öğe Assessment of biochemical bone markers of osteoporosis in children with thalassemia major(Bmc, 2022) Celik, Tanju; Sangun, Ozlem; Unal, Sule; Balci, Ali; Motor, SedatBackground Beta thalassemia major (beta-TM) is a common cause of skeletal morbidity and is associated with increased bone fracture risk, particularly in inadequately transfused children. The aim of this study was to investigate some potential biochemical markers as possible early predictors of BMD variations in children with beta-TM. Methods The study included 38 children with beta-TM and 40 sex-age matched controls. All patients were subjected to BMD assessment by dual-energy X-ray absorptiometry (DEXA). Serum beta-crosslaps (beta-CTx), osteoprotegerin (OPG), receptor activator of nuclear factor-kappa B ligand (RANKL), urinary deoxypyridinoline (DPD) and ferritin levels were compared between the groups. Results Serum OPG levels were significantly lower in thalassemic children than in controls. The mean ratio of RANKL/OPG was significantly higher in the thalassemic patients than in the control group. Osteoporosis was detected in 10 (3 female and 7 male) of 38 patients (26.3%) according to the femur Z score and in 6 of them (4 male and 2 female) (15.8%) according to the spine Z score. Conclusions Serum OPG concentrations can be used as a biochemical marker in screening patients with beta-thalassemia major for the development of osteoporosis.Öğe Atypical Herpes Simplex Encephalitis With Extratemporal Involvement(Lippincott Williams & Wilkins, 2007) Okuyucu, Esra; Melek, Ismet; Duman, Taskin; Balci, Ali; Eraslan, TuraliHerpes simplex virus (HSV) is recognized as the most common cause of sporadic encephalitis among adults. The combination of magnetic resonance imaging, electroencephalography, and cerebrospinal fluid tests is usually diagnostic. In this article, we describe a case of atypical HSV encephalitis presenting a syndrome of febrile encephalopathy in the absence of focal neurological features, including mental and sensory disturbance, pyramidal signs, ataxia, and cranial nerve deficits, and in which magnetic resonance imaging demonstrated lesions restricted to the parietal and occipital lobes without typical localization of HSV encephalitis in the insula and inferior frontal lobe.Öğe Gradual detorsion of torsioned rat testis attenuates ischemia reperfusion injury(W B Saunders Co-Elsevier Inc, 2008) Akcora, Bulent; Altug, Muhammed E.; Balci, Ali; Hakverdi, Sibel; Yonden, Zafer; Akbas, Ali; Ozturk, AtakanAim: This study was designed to investigate effect of gradual detorsion on testicular ischemia reperfusion injury. Materials and Methods: A total of 21 male rats were divided into 3 groups, each containing 7 rats. Torsion was created by rotating the left testis 720 degrees in a clockwise direction. Group I underwent sham operation. Group 2 (sudden detorsion) served as a torsion/detorsion group, receiving 2 hours torsion and 2 hours detorsion. In group 3, 360 degrees detorsion was done for 20 minutes after 720 degrees torsion for 2 hours. Then, testis was done full detorsion for 100 minutes. At the end of the experiments (fourth hour), left orchiectomy was performed to measure the tissue levels of malondialdehyde (MDA), superoxide dismutase, and glutathione peroxidase and to perform histologic examination in testes. Results: The MDA levels of testis tissues were significantly increased in the sudden detorsion group as compared with the sham group. We found decrease of the MIDA level in gradual detorsion group, but it was not a statistically significant amount. Significant decrease was found in the superoxide dismutase and glutathione peroxidase activities in the sudden detorsion group as compared with the sham and gradual detorsion groups. Histologic examinations were in accordance with the testicular tissue MDA levels. Conclusion: In the light of our biochemical and histopathologic findings, we can say that gradual detorsion has a trend to decrease the degree of testicular reperfusion injury in the rat torsion/detorsion model. (C) 2008 Elsevier Inc. All rights reserved.Öğe Graves' Disease with Exophtalmia in a Two-Year Old Child(Galenos Yayincilik, 2011) Yalcin, Hulya; Akcora, Bulent; Balci, AliThyrotoxicosis is one of the rare disorders diagnosed in childhood and adolescence. The most frequent cause is Graves disease. One of the Graves' disease complications is thyroid-associated orbitopathy. A 2-year-old girl was referred to our hospital for decreased weight gain. Her physical examination was normal except for a palpable thyroid tissue and exophtalmia. After laboratory examination, she was referred to the departments of nuclear medicine and radiology for the diagnosis of hyperthyroidism and Graves ophthalmia. When evaluated with the physical examination, laboratory and imaging results the patient was diagnosed as Graves' disease with orbital involvement. So the patient was taken on methimazole treatment.Öğe The importance of the M470V polymorphism(Dr Behcet Uz Cocuk Hastaliklari Ve Cerrahisi, 2017) Celik, Tanju; Gunesacar, Ramazan; Balci, Ali; Unal, Sule; Aldic, Guliz; Eskici, Harika; Atilgan, NigarObjective: Several hundreds of cystic fibrosis transmembrane conductance regulator (CFTR) variants have been reported, however it is not known whether which one of them was causing the disease of cystic fibrosis (CF) or not. Information about CFTR genes carrying the M470 or the V470 allele are interesting. In this study, we aimed to investigate the clinical importance of M470V mutation in Antiochia region. Methods: A case-control study consisted of 145 children from whom CF gene study was requested because of recurrent respiratory tract infections, growth failure, chronic diarrhea and constipation. The parameters of patients with positive mutation were compared with negative ones as for gender, age, height, weight, annual number of upper and lower respiratory tract infections, parental consanguinity, sibling death, clinical and laboratory parametres. Results: In 63 of 145 patients (43.4%), heterozygous mutation, in 16 (11%) of them homozygous mutation was detected. All of the patients with mutation group had M470V mutation. The sweat test results of all patients were within normal limits. Mean age of those patients were 41.21 +/- 39.8 (min: 6 max: 192) months and 30 (38%) of them were girls. Thirty percent of the patients with mutation (n=17.7) had a familial history of cystic fibrosis, 2 a history of sibling death. In the mutation group, only annual number of infections, skin dryness, loss of weight, level of IgG and IgM were significantly higher (p<0.05). Conclusion: It was concluded that in M470V positive cases, the disease may cause clinical symptoms without affecting sweat test results, with less gastrointestinal but more respiratory symptoms, causing a more prominent loss of weight.Öğe Increased Amount of Visceral Fat in Patients with Psoriasis Contributes to Metabolic Syndrome(Karger, 2010) Balci, Ali; Balci, Didem Didar; Yonden, Zafer; Korkmaz, Inan; Yenin, Julide Zehra; Celik, Ebru; Okumus, NeseBackground: Psoriasis is associated with obesity and metabolic syndrome. Metabolic syndrome is associated with visceral fat accumulation. There is no study on the accumulation of visceral fat in patients with psoriasis. Objective: The aim of this study was to compare the visceral fat accumulation in patients with psoriasis and controls. Subjects and Methods: 46 patients with psoriasis and 46 sex-and age-matched control patients were included in this study. The abdominal fat area [visceral fat area (VFA), subcutaneous fat area (SFA) and total fat area (TFA)] at the level of the umbilicus was evaluated by computed tomography. Results: The mean VFA value and VFA/SFA ratio of the psoriasis patients were significantly higher compared with the control patients (123.4 +/- 80.3 vs. 81.2 +/- 59.8 cm(2) and 0.734 +/- 0.593 vs. 0.491 +/- 0.336; p = 0.005 and p = 0.017, respectively). Fasting blood sugar levels were also found to be significantly higher in psoriasis patients, compared with the control patients (101.8 +/- 43.5 vs. 83.4 +/- 9.1 mg/dl; p = 0.005). Multiple linear regression analysis indicated that waist-to-hip ratio, age, body weight, the presence of psoriasis and metabolic syndrome were significantly associated with VFA. Conclusion: Psoriasis patients had a higher amount of VFA, compared with the control patients. Copyright (C) 2009 S. Karger AG, BaselÖğe Intralober Pulmonary Sequestration with Arterial Supply from Two Different Origins: A Case Report(Medical Tribune Inc, 2012) Erden, Ersin Sukru; Yetim, Tulin Durgun; Balci, Ali; Akcay, Adnan Burak; Hakverdi, Sibel; Demirkose, MesutPulmonary sequestration is a rare anomaly, which does not have a connection with the bronchial system and gets its blood supply, generally, from the aorta or its branches. Anatomically, two different forms were described: intralobar and extralobar. Although 74% of intralobar pulmonary sequestrations get their blood supply from the descending thoracic aorta, they may get their blood supply from different arteries. Furthermore, there is more than one arterial anomaly in 14.8% of cases. We report an intralobar pulmonary sequestration, in which arterial blood supply is from two different origins (Arcus aorta and celiac trunk). To the best of our knowledge, this is the first case in the literature.Öğe Median arcuate ligament syndrome diagnosed with multisliced computerized tomography: A case report(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2012) Bayarogullari, Hanifi; Davran, Ramazan; Aslan, Ahmet; Korkmaz, Inan; Yanmaz, Rasim; Temiz, Muhyittin; Balci, AliMedian arcuate ligament syndrome occurs when median arcuate ligament pressures the root of the celiac artery and generally it reveals itself with the post-prandial pain. Because of the pressure there will be a significant tightness especially while expirium. Mesenteric ischaemia and low blood flow to gastro-intestinal system occurs related to the tightness and because of these we see the characteristic clinical symptoms of the syndrome. We present the patient whom we diagnosed with multislicde computerized tomograpy.Öğe Neurologic Soft Signs in Behcet Disease(Lippincott Williams & Wilkins, 2010) Okuyucu, Esra E.; Balci, Didem D.; Balci, Ali; Duman, Taskin; Akcin, EbruBackground: Patients with Behcet disease have an excess of minor neurologic abnormalities (neurologic soft signs). Objective: (a) To investigate the neurologic soft signs (NSS) in Behcet disease (BD) patients who had no neurologic symptoms, by using the neurologic evaluation scale (NES). (b) To evaluate the effect of silent infarction on NES scores in BD patients. Methods: Thirty six BD patients without neurologic symptoms and 36 healthy controls were included M the study. NSS were assessed with the NES. Cranial magnetic resonance imaging was conducted to determine the presence of silent cerebral infarcts. Results: Patients with BD had significantly higher scores overall and on each subscale (except for subscale others) of the NES than the control group's. Tandem walk, adventitious overflow, tremor, graphesthesia, fist edge palm test, Ozeretski test, finger thumb opposition, mirror movements, extinction, synkinesis, convergence, finger nose test, glabellar reflex, grasp reflex, and suck reflex were also significantly higher in patients with BD than in the healthy control group. There were no significant differences in the total NES scores, total subscale scores and each of the NES items between BD patients with silent infarction and those without infarction. Conclusion: Early diagnosis of neurologic involvement in BD is important and the NES is a useful instrument for detecting subchnical neurologic involvement in BD patients.Öğe Pituitary apoplexy due to thyroxine therapy in a patient with congenital hypothyroidism(2013) Tutanc, Murat; Altas, Murat; Yengil, Erhan; Ustun, Ihsan; Dolapcioglu, Kenan S.; Balci, Ali; Sefil, FatihA 24-year-old woman was admitted with general weakness, umbilical swelling, developmental delay, speech disorder, constipation, gait problem. Her findings were umbilical hernia, xerosis, dry hair, and short stature. After thyroxine treatment, she also had headache, vomiting, and palpitation, lack of appetite, and sleep disturbance. Pituitary magnetic resonance imaging revealed a heterogeneous mass at the central part of the gland on coronal section and it was interpreted as pituitary apoplexy. In the current case, the patient with congenital hypothyroidism (CH) developed pituitary apoplexy (PA) after thyroxine therapy. Therefore, it is suggested that the complaints were related to PA rather than adrenal insufficiency. Here we describe a case report evaluating PA in a patient with thyrotrophic pituitary adenoma due to CH. To the best of our knowledge, this is the first case in terms of PA associated with CH after thyroxine therapy in the literature.Öğe PREVALANCE AND CLINICAL FINDINGS OF PRIMARY HEADACHES IN PEOPLE WITH MULTIPLE SCLEROSIS(Nobel Ilac, 2009) Okuyucu, E. Esra; Balci, Ali; Beyaz, OezguerObjective: The aim of the study was to investigate the prevalance of primary headache and clinical evaluation Of primary headaches according to the International Headache Society criteria in patients with multiple sclerosis. The relationship between primary headache and multiple sclerosis subtypes, locations of plaques on magnetic resonance of these patients were also investigated. Material and Method: A total of 3.1 patients with clinically definite MS according to the McDonald's criteria, 22 females and 9 men, were included in the study. The Study conducted in two phases; face-to-face interview phase and evaluation of magnetic resonance imaging phase. Results: The prevalance of all headaches was 71.0% in 31 patients. Migraine without aura was found in 22.6%, migraine with aura in 19.4% and tension type headache in 29%. Primary headaches were found to be most common in relapsing-remitting MS. Lesions of red nucleus (RNT), substantia migra (SN), periaquaductal gray matter (PGM), dorsolateral pontine nucleus (DPN) were found in all patients, with frequency from 22.6% to 48.4%. While all patients with migraine had supratentoriel lesion, neither of the patients had infratentoriel lesion alone. Conclusion: The findings suggest that primary headaches are common in patients with multiple sclerosis. Demyelinating lesions in RN, SN, PGM, DPN might be responsible from the presence of primary headaches in patients with MS. But for understanding the mechanisms underlying this association, further studies are needed.Öğe Retrograde filling carotid-cavernous fistula: MSCT angiography findings(Springer, 2012) Bayarogullari, Hanifi; Beyoglu, Yeliz; Balci, Ali; Karaoglu, Ece; Davran, Ramazan; Altas, Murat[Abstract Not Available]Öğe [Superior semicircular canal dehiscence syndrome: report of three cases].(2011) Cokkeser, Yaşar; Bayaro?ullari, Hanifi; Kahraman, Serif Samil; Tuncer, Ulkü; Firincio?ullari, Riza; Beyo?lu, Yeliz; Balci, AliSuperior semicircular canal dehiscence syndrome is a newly defined and rare disease. The disease shows itself with vertigo and nystagmus induced by loud noise and pressure. Vertigo and nystagmus induced by loud noise is named as Tullio's phenomenon and nystagmus induced by pressure is named as Hennebert's sign. The definitive diagnosis is made by the demonstration of bone defect in superior semicircular channel with high-resolution computed tomography.
