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Öğe Acne Vulgaris and Acne Rosacea: An Update in Etiopathogenesis(Derman Medical Publ, 2014) Ekiz, Ozlem; Balta, IlknurAcne vulgaris is a chronic inflammatory disease of the pilosebaceous unit, characterized by comedones, papules, pustules, nodules, and scars rarely. The major pathogenic factors are abnormal activity of sebaceous glands, microbial colonization. Rosacea is a common, chronic inflammatory relapsing skin disorder of the central area of the face characterized by transient or persistent erythema, telangiectasia, papules and pustules. Although several hypotheses have been suggested for the etiopathogenesis of rosacea, the exact etiology is still unknown. In this review, we tried to summarize up-to-date information about etiopathogenesis of acne vulgaris and rosocea.Öğe Aortic Arterial Stiffness is a Moderate Predictor of Cardiovascular Disease in Patients With Psoriasis Vulgaris(Sage Publications Inc, 2014) Balta, Ilknur; Balta, Sevket; Demirkol, Sait; Celik, Turgay; Ekiz, Ozlem; Cakar, Mustafa; Sarlak, HakanPsoriasis is associated with an increased risk of atherosclerosis. Endothelial dysfunction is the critical early step in the process of atherogenesis, and it is commonly investigated by measuring arterial stiffness. We aimed to investigate the relationship between arterial stiffness and high-sensitivity C-reactive protein (hsCRP) in patients with psoriasis. A total of 32 patients with psoriasis and 35 patients with other skin diseases were included in the study. The hsCRP levels and arterial stiffness measurements were compared. Arterial stiffness was significantly different between the 2 groups (P = .01). Arterial stiffness was not associated with the duration of the disease or the disease activity (P = .34 and .64, respectively). In patients with psoriasis, arterial stiffness correlated positively with age, sex, body mass index, diastolic blood pressure, and hsCRP level (P < .05). These findings provide further evidence of a link between inflammation, premature atherosclerosis, and psoriasis.Öğe Arterial Stiffness Parameters Should be Evaluated With Different Types of Psoriasis(Sage Publications Inc, 2014) Balta, Ilknur; Balta, Sevket; Demir, Mustafa; Demirkol, Sait; Ekiz, Ozlem; Unlu, Murat[Abstract Not Available]Öğe Assessment of thyroid function and lipid profile in patients with postadolescent acne in a Mediterranean population from Turkey(Wiley-Blackwell, 2015) Ekiz, Ozlem; Balta, Ilknur; Unlu, Ezgi; Sen, Bilge Bulbul; Rifaioglu, Emine N.; Dogramaci, Asena C.BackgroundPostadolescent acne is defined as acne that is seen even after the age of 25years, regardless of the age at onset. The causes of postadolescent acne have not been completely clarified up to now. Androgens are considered to be the major factor involved in pathogenesis. ObjectiveWe aimed to investigate the status of thyroid functions and lipid levels in patients with postadolescent acne and determine the effects of lifestyle and environmental factors on postadolescent acne in a Turkish population. MethodsIn total, 184 patients and 82 healthy controls were enrolled in the study. Thyroid function and lipid profiles of all participants were analyzed. ResultsThe mean age of patients was 30.44.9years (25-50). The mean age of control group was 30.0 +/- 4.4years (25-40). Cigarette smoking was significantly associated with postadolescent acne (P<0.001). No significant differences were observed between patients with postadolescent acne and control subjects in triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels, thyroid hormone profiles, and thyroid ultrasound scans. High-density lipoprotein cholesterol levels were significantly decreased with postadolescent acne (P=0.01). ConclusionsTo our knowledge, this is the first study to investigate the thyroid functions and lipid profile in men and women with postadolescent acne. In this study, there was no relationship between thyroid functions and postadolescent acne. However, an association with low high-density lipoprotein cholesterol levels and postadolescent acne was detected. Further investigations with more patients in different populations are needed to determine the causes of postadolescent acne.Öğe The Association Between Inflammatory Markers and the Degree of Psoriasis Vulgaris(Sage Publications Inc, 2014) Balta, Ilknur; Balta, Sevket; Demirkol, Sait; Ekiz, Ozlem; Sarlak, Hakan; Cakar, Mustafa[Abstract Not Available]Öğe A Case Report: Lichen Simplex Chronics Mimicking Bowen's Disease(Derman Medical Publ, 2014) Balta, Ilknur; Simsek, Gulcin Guler; Ekiz, Ozlem; Balta, Sevkat; Demirkol, SaitLichen simplex chronicus (LSC), also known as neurodermatitis. It can present clinically as isolated or multiple lichenified thickened plaques that are usually hyper pigmented and excoriated with accentuated skin markings. The diagnosis of LSC is usually easily made from characteristic lesions. In more difficult cases histopathological study is useful. A 59-year-old male patient had a one-year history of erythema and crusts beginning on the left lumbar region and enlarging peripherally. His past medical history was unremarkable. Dermatological examination revealed 3x4 cm sharply demarcated, erytherhatous, slightly scaling and crusted solitary plaque on the left lumbar region. Because of the clinical characteristics of the lesions, Bowen's disease was suspected clinically in the diagnosis of the disease. Histological exam sat was compatible with the diagnosis of LSC. Thus, a diagnosis of Bowen's disease was eliminated. Our case is presented in order to remind that LSC should be kept in mind, in differential diagnosis of Bowen's disease.Öğe The effect of personal, familial, and environmental characteristics on acne vulgaris: a prospective, multicenter, case controlled study(Edizioni Minerva Medica, 2019) Karadag, Ayse S.; Balta, Ilknur; Saricaoglu, Hayriye; Kilic, Selim; Kelekci, Kiymet H.; Yildirim, Mehmet; Arica, Deniz A.BACKGROUND: There are only a few studies about epidemiological features of acne vulgaris in the literature. The aim of this study was to analyze demographic, clinical, familial and environmental characteristics of acne, the role of diet and aggravating factors and association of these factors with acne severity. METHODS: Patients with a diagnosis of mild-moderate to severe acne were consecutively interviewed at the participating centers during the study period. RESULTS: A total of 3826 patients and 759 control patients were involved in this study. Mild acne was the most common type of acne, and most of the lesions were localized on face followed by the trunk. The severity of acne was worse in patients who had a positive family history of acne. The most common triggering factor was psychological stress. We found a positive correlation with chocolate, bread, green tea, milk, white sugar, ripe banana, ice cream, apple, orange, and red meat consumption. As we compare the acne severity according to geographical features we detected mild-moderate acne was more common in Mediterranean region and severe acne was more common in East Anatolian region. Family history positivity was more common in Aegean region and least common in Central Anatolian region. There was statistically significant relationship as we compare acne severity and dietary factors such as chocolate, dairy products such as milk, sunflower seed consumption within the geographical regions. CONCLUSIONS: This study presents the demographic and clinical characteristics of acne patients in Asian and the European parts of Turkey. We believe that this study will provide a useful overview of acne in Turkey.Öğe The Etiology of Behcet Disease: Is It Really Inflammation or Not!(Sage Publications Inc, 2014) Ekiz, Ozlem; Balta, Ilknur; Sen, Bilge Bulbul; Rifaioglu, Emine Nur; Balta, Sevket; Demirkol, Sait[Abstract Not Available]Öğe Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris(Taylor & Francis Ltd, 2014) Ozuguz, Pinar; Kacar, Seval Dogruk; Ekiz, Ozlem; Takci, Zennure; Balta, Ilknur; Kalkan, GoknurBackground: Although hyperseborrhea, follicular hyperkeratinization, Propionibacterium acnes colonization and inflammation are found to be responsible in the pathogenesis of acne, the exact mechanisms are unknown. Vitamin A and E are basic antioxidants vital for health. Zinc is also an essential element for human. But these parameters of the effects on skin are not fully understood. We aimed to evaluate plasma levels of vitamin A, E and zinc in acne patients in relation to the severity of the disease. Material and method: There were 94 acne patients who were referred to our clinic, all new diagnosed, and 56 age and sex matched healthy volunteers as control group. All patients are assessed according to Global Acne Grading System and grouped as mild, moderate, severe and very severe. Acne patients further grouped as group 1 consist of patients with mild to moderate disease; and group 2 consist of patients with severe to very severe acne. The patients with the controls and group 1 with group 2 was compared. Results: The level of vitamin E, vitamin A and zinc were significantly lower than the control group (Table 1, p<0.001). When the patient group is compared among each other there was no statistically significant difference for plasma vitamin A levels between group 1 and 2 whereas vitamin E and zinc levels were significantly low in group 2 than group 1. Thus there was a negative correlation between acne severity and vitamin E and zinc levels. Conclusion: Our study marks the importance of diet in patients with acne. We offer supportive dietary measures with foods rich in vitamin A and E and zinc in the acne prophylaxis and treatment. Supportive treatment with these vitamins and zinc in severe acne may lead to satisfactory results.Öğe Insulin resistance in patients with post-adolescent acne(Wiley-Blackwell, 2015) Balta, Ilknur; Ekiz, Ozlem; Ozuguz, Pinar; Ustun, Ihsan; Karaca, Semsettin; Kacar, Seval Dogruk; Eksioglu, MeralBackgroundPost-adolescent acne has been defined as acne in a patient aged >25years. Acne vulgaris first develops at the onset of puberty as a result of hormonal changes. During puberty, there is a transient decline in insulin sensitivity. We hypothesized that insulin resistance might persist after puberty in patients with post-adolescent acne. ObjectivesThis study was conducted in order to investigate the relationship between post-adolescent acne and insulin resistance. MethodsThe study population comprised 35 patients with post-adolescent acne and 35 healthy control subjects. The parameters measured were fasting blood glucose, insulin, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), total cholesterol (TC), triglycerides, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). The homeostasis model assessment of insulin resistance (HOMA-IR) index was calculated for each individual. ResultsNo significant differences were observed between patients with post-adolescent acne and control subjects in fasting blood glucose, fasting insulin, AST, ALT, triglyceride and HDL-C levels, and HOMA-IR index. There were also no correlations between these parameters and the severity of acne. ConclusionsThis study suggests that insulin resistance may not play a major role in the pathogenesis of post-adolescent acne. Hormonal changes, genetic susceptibility, stress, the use of cosmetics, drugs, and environmental factors should be considered in the development of post-adolescent acne.Öğe Mean Platelet Volume as an Inflammatory Indicator in Behcet Disease(Sage Publications Inc, 2014) Ekiz, Ozlem; Balta, Ilknur; Sen, Bilge Bulbul; Rifaioglu, Emine Nur; Balta, Sevket; Demirkol, Sait[Abstract Not Available]Öğe Mean Platelet Volume in Recurrent Aphthous Stomatitis and Behcet Disease(Sage Publications Inc, 2014) Ekiz, Ozlem; Balta, Ilknur; Sen, Bilge Bulbul; Rifaioglu, Emine Nur; Ergin, Can; Balta, Sevket; Demirkol, SaitBehcet disease (BD) and recurrent aphthous stomatitis (RAS) are systemic inflammatory diseases, but the exact pathogenesis of both the diseases is unknown. Mean platelet volume (MPV) is an indicator of platelet activation. The aim of this study was to investigate the MPV levels in patients with BD, RAS, and healthy participants. A total of 61 patients with BD, 60 patients with RAS, and 60 healthy controls were included in this study. The MPV levels and erythrocyte sedimentation rate in patients with BD and RAS groups were significantly higher than the control groups (P < .001). In the BD group as well as in the RAS group, the disease activity does not affect the levels of MPV. The MPV levels may be used as a cheap and feasible diagnostic marker in patients with BD and RAS. Nevertheless, the MPV does not have a predictive value in differentiating the diagnosis of BD and RAS.Öğe Nutritional anemia in reproductive age women with postadolescent acne(Taylor & Francis Ltd, 2013) Balta, Ilknur; Ekiz, Ozlem; Ozuguz, Pinar; Sen, Bilge Bulbul; Balta, Sevket; Cakar, Mustafa; Demirkol, SaitContext: Postadolescent acne has been defined as the presence of acne beyond the age of 25 years. Postadolescent acne affects approximately 14% of women between the ages of 25 and 50 years. Namely, postadolescent acne usually occurs in women of reproductive age. Nutritional anemia occurs from an insufficient intake of nutrients such as iron, folate and vitamin B12. It is very common in women of reproductive age. Nutritional anemia causes irritability, apathy, fatigue, depressive symptoms and difficulty in concentration. The major etiological factor in adult acne can be increased levels of emotional stress, leading to increase in adrenal androgens. Thus, nutritional anemia may aggravate the lesions of acne by affecting the emotional status in women of reproductive age. Objective: We aimed to investigate the relationship between postadolescent acne and nutritional anemia in this study. Materials and methods: The study population comprised of 52 patients with postadolescent acne and 52 healthy control subjects. Hemogram, vitamin B12, folate, serum iron, ferritin and total iron-binding capacity (TIBC) were measured. Results: No significant differences were observed between both groups in hemoglobin, vitamin B12, serum iron, ferritin and TIBC levels. Serum folate levels were significantly decreased in postadolescent acne patients (p<0.001). There were no significant correlations between hemoglobin, vitamin B12, folate, serum iron, ferritin and TIBC levels and acne severity. Discussion and conclusion: We could not find any relationship between postadolescent acne and nutritional anemia in our study. However, serum folate levels were decreased in postadolescent acne patients. Prospective research studies are needed to clarify the role of nutrition in the pathophysiology of postadolescent acne. We think that nutritional interventions can be inexpensive, safe, easy to administer and generally acceptable to patients with postadolescent acne.Öğe Papular Mycosis Fungoides: A Case Report and Review in the Literature(Medknow Publications & Media Pvt Ltd, 2015) Balta, Ilknur; Akbay, Gulfer; Eksioglu, Meral; Astarci, Muzeyyen; Ekiz, Ozlem[Abstract Not Available]Öğe Vitamin D status in patients with rosacea(Taylor & Francis Ltd, 2014) Ekiz, Ozlem; Balta, Ilknur; Sen, Bilge Bulbul; Dikilitas, Meltem Cik; Ozuguz, Pinar; Rifaioglu, Emine NurBackground: Rosacea is a common chronic skin condition affecting the face. In recent years, significant evidence shows that vitamin D plays an important role in modulating the immune system. Vitamin D and its analogues via these mechanisms are playing an increasing role in the management of atopic dermatitis, psoriasis, vitiligo, acne and rosacea. Objectives: In our study, we aimed to investigate the relationship between serum vitamin D levels in patients with rosacea and analyze the association of vitamin D with clinical features. Methods: Forty-four rosacea patients and 32 healthy control subjects were included into the study. 25-hydroxyvitamin D (25(OH)D), calcium and intact parathyroid hormone were measured. Deficiency of vitamin D is defined as the level of 25(OH)D being less than 20 ng/ml. Results: Thirty-three female and 11 male patients were included in the study. The mean age of patients was 48.6 +/- 11.5. The mean levels of vitamin D levels were found as 21.4 +/- 9.9 and 17.1 +/- 7.9 in patients and controls, respectively. The difference was statistically significant (p = 0.04). The prevalence of vitamin D deficiency in patients with rosacea was 38.6% and 28.1% in healthy controls (p = 0.34). Conclusions: To the best of our knowledge, our study is the first study for evaluating serum vitamin D levels of patients with rosacea in the literature. Patients with rosacea have relatively high serum vitamin D levels compared to control groups. The result of our study suggests that increased vitamin D levels may lead to the development of rosacea. To confirm status of vitamin D levels in patients with rosacea, larger epidemiological studies are needed.
