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Öğe Closed lip schizencephaly: A case report(Dr Behcet Uz Cocuk Hastaliklari Ve Cerrahisi, 2012) Arica, Vefik; Karakus, Ali; Silfeler, Ibrahim; Arica, Secil Gunher; Altas, Murat; Tutanc, Murat; Basarslan, FatmagulSchizencephaly, has been defined as an almost symmetrical bilateral cleft along the cerebral hemisphere. Clinical findings in patients with schizencephaly depends on the type of clefts (on of off type) and the amount of malformed parenchyma. Incidence of schizencephaly is unclear, while a population-based study performed in the United States reported its incidence as 1.54: 100000. These types of cortical developmental malformations had variable clinical signs depending on the function of the affected area which range widely from mental-motor retardation and epilepsy to focal neurological disorders. We also presented a very rare case with bilateral cleft palate aged 4 years who was referred with recurrent afebrile convulsive episodes and diagnosed as schizencephaly, subependimal heterotopia and temporal lobe epilepsy by cranial MRIÖğe Determination of hearing levels in patients with Familial Mediterranean Fever(2013) Cevik, Cengiz; Silfeler, Ibrahim; Arica, Vefik; Yengil, Erhan; Akbay, Ercan; Sarac, Tuba; Basarslan, FatmagulObjective: Familial Mediterranean Fever is the most common congenital, periodic fever condition that affects over 100,000 people worldwide. In the literature, there is limited number of studies about hearing levels in children with Familial Mediterranean Fever. In the present study, we aimed to investigate hearing levels and cochlear functions by using Distortion product Otoacoustic Emission and High Frequency Audiometry (250-20,000. Hz) in pediatric patients with Familial Mediterranean Fever. Methods: The study included 62 children with Familial Mediterranean Fever and 27 healthy children with similar age and gender. After otoscopic examination, both groups underwent audiological evaluation including High Frequency Audiometry (250-20,000. Hz) and Distortion product Otoacoustic Emissions. The results obtained were assessed among groups. In addition, these results were compared regarding colchicine use, age at the onset of disease and duration of the diseases in the Familial Mediterranean Fever group. Results: Of the Familial Mediterranean Fever patients, 93.5% were on colchicine therapy and mean duration of colchicine use was 19.9 ± 13.9 months. The mean age at diagnosis was 6.57 ± 2.86 years (min-max: 2-14) and mean duration of disease was 23 ± 17 months (min-max: 6-84). Pure tone audiometry values, and hearing levels between 9000 and 20,000. Hz were similar and within normal range in both groups. The Distortion product Otoacoustic Emissions responses at the frequencies of 1020, 2040, 3000, 4080 and 5040. Hz were similar for both groups. Conclusion: To the best of our knowledge, this is the first study evaluating hearing levels at the frequencies of 18. kHz and 20. kHz in children with Familial Mediterranean Fever in the literature. In children with Familial Mediterranean Fever, Pure tone audiometry values, hearing values obtained at all frequencies from 250 to 20,000. Hz, and Distortion product Otoacoustic Emissions levels were within normal range. Furthermore, hearing levels were found to be similar to those in healthy children. © 2013 Elsevier Ireland Ltd.Öğe Dual effects of erdosteine on hemostasis via its different metabolites in young rats(Sage Publications Ltd, 2011) Arica, Vefik; Tutanc, Murat; Ozturk, Oktay Hasan; Arica, Secil; Basarslan, Fatmagul; Erden, Ersin Sukru; Oktar, SuleymanAim: In the study, we examined erdosteine's effects on platelet functions and coagulation. Materials and methods: A total 29 young albino Wistar rats were divided into four groups. Control rats (n = 6) were given saline; Group I rats (n = 7) were given 3 mg/kg erdosteine by oral gavage for 3 days; Group 2 rats (n = 7) were given 10 mg/kg erdosteine by oral gavage for 3 days; and Group 3 rats (n = 9) were given 30 mg/kg erdosteine for 3 days. Twenty-four hours after the final dose, blood samples were drawn from a portal vein. Prothrombin time (PT), activated partial thromboplastin time (aPTT) and international normalized ratio (INR) were measured, and platelet counts were examined in a peripheral blood smear by light microscopy. Results: PT and INR values of Group I increased compared to the controls but did not change in Group 3. Hemostatic parameters were not measured in Group 2 because the blood samples in Group 2's tubes clotted rapidly. Platelet counts of the peripheral blood from Group 2 were low but were normal in other groups. Conclusion: We have concluded erdosteine may disrupt hemostasis parameters by its different metabolites in patients. Erdosteine has dual effects on hemostasis via its different metabolites, which occur in different doses.Öğe Effects of ebselen on radiocontrast media-induced hepatotoxicity in rats(Sage Publications Inc, 2013) Basarslan, Fatmagul; Yilmaz, Nigar; Davarci, Isil; Akin, Mustafa; Ozgur, Mustafa; Yilmaz, Cahide; Ulutas, Kemal TurkerOxidative stress is accepted as a potential responsible mechanism in the pathogenesis of radiocontrast media (RCM)-induced hepatotoxicity. Therefore, we aimed to investigate the protective effects of ebselen against RCM-induced hepatotoxicity by measuring tissue oxidant/antioxidant parameters and histological changes in rats. Wistar albino rats were randomly separated into four groups consisting of eight rats per group. Normal saline was given to the rats in control group (group 1). RCM was given to the rats in group 2, and both RCM and ebselen were given to the rats in group 3. Only ebselen was given to the rats in group 4. Liver sections of the killed animals were analyzed to measure the levels of malondialdehyde (MDA) and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), as well as histopathological changes. In RCM group, SOD and CAT levels were found increased. In RCM-ebselen group, MDA, SOD and CAT levels were found decreased. In RCM-ebselen group, however, GSH-Px activities of liver tissue increased. All these results indicated that ebselen produced a protective mechanism against RCM-induced hepatotoxicity and took part in oxidative stress.Öğe Evaluation of cases with diabetic ketoacidosis monitorized in intensive care units(Dr Behcet Uz Cocuk Hastaliklari Ve Cerrahisi, 2011) Tutanc, Murat; Celik, Tanju; Basarslan, Fatmagul; Gunes, Ali; Konca, Capan; Yel, Servet; Bosnak, MehmetObjective: In this study, we have investigated the demographic and clinical characteristics of pediatric cases with diabetic - ketoacidosis (DKA) followed-up in intensive care units. Methods: This is a retrospective analysis of all patients' files with respect to their demographic factors as gender, complaints, age and clinical features. Mann Whitney U and chi-square statistical tests were performed. Results: The study group consists 16 female and 9 male children with a mean age of 9.9 +/- 3.7 years. The most frequent complaints of the cases were dyspnea, polydipsia, weight loss and polyuria in decreasing order of frequency. They admitted to the hospital because of respiratory distress, tachypnea tachycardia and acidosis. They treated by DKA protocol in the intensive care unit. We normalized Glasgow Coma Scores (GKS) in 12 +/- 5, blood sugar levels in 14 +/- 7, and blood gas levels in 14 +/- 7 hours. Any complication had not developed and the patients under glycemic control were discharged from the hospital with recommendations for outpatient follow-up. Conclusion: DKA cases could be treated rapidly and successfully thanks to accurate and rapid diagnosis followed by strict monitorization protocol. In conclusion we wanted to emphasize that monitorization of patients with DKA should be performed in pediatric intensive care units.Öğe Evaluation of Lymphocyte Subgroups in Children With Down Syndrome(Sage Publications Inc, 2015) Yilmaz, Cahide; Dogan, Murat; Basarslan, Fatmagul; Yilmaz, Nebi; Yuca, Sevil; Bulan, Keziban; Kaya, AvniIn this study, lymphocyte subgroups including blood CD3, CD4, CD8, CD4/CD8, CD19, and CD16.56 values were analyzed in children with Down syndrome (DS). The study includes 85 children with DS, followed at Department of Pediatrics, Faculty of Medicine, Yuzuncu Yil University and 64 healthy age-matched control participants. Blood CD3, CD4, CD8, CD4/CD8, CD19, and CD16.56 values were examined in both the groups. Significantly decreased blood CD3, CD4, and CD19 values were found in the study group (P < .05) when compared with the control group. In conclusion, we would like to emphasize that blood CD3, CD4, and CD19 levels were found to be decreased in children with DS. Based on these finding, we think that these decreased lymphocyte subgroups might be responsible for increased susceptibility to infections in children with DS.Öğe Fukuyama congenital muscular dystrophy(Professional Medical Publications, 2012) Silfeler, Ibrahim; Arica, Vefik; Davran, Ramazan; Tutanc, Murat; Basarslan, FatmagulMuscular dystrophy is an inherited group of disorders that affects skeletal and many other systems. It is transferred to the next generations with autosomal recessive trait. Congenital muscular dystrophy is a rare disorder characterized by findings emerging from birth. There are 12 different forms of mutation according to defects. Fukuyama syndrome is a rare form of congenital muscular dystrophies in our country. There is FKTN gene mutation. Because it is a rare disease in Turkey, we find this case to be worthy of presentation. After the delivery, patients with recurrent convulsion and hypotonia were admitted to pediatric emergency department. Patients were diagnosed as Fukuyama congenital muscular dystrophy after evaluation based on clinical findings, imaging techniques and gene analysis. Congenital muscular dystrophy should be considered, whereas it is a group of disease in which hypotonia and recurrent convulsions are seen in early infancy period.Öğe The impact of different antiepileptic drugs on the sedation of children during magnetic resonance imaging(Elsevier Science Inc, 2014) Davarci, Isil; Karcioglu, Murat; Tuzcu, Kasim; Basarslan, Fatmagul; Davran, Ramazan; Yengil, Erhan; Yilmaz, CahideBackground and objectives: The induction and inhibition of cytochrome P450 isoenzymes by antiepileptic drugs lead to changes in the clearance of anesthetic drugs eliminated via hepatic metabolism. We investigated the duration of the sedation and additional anesthetic needs during magnetic resonance imaging in epileptic children receiving antiepileptic drugs that cause either enzyme induction or inhibition. Methods: In American Society of Anesthesiology I-II, 120 children aged 3-10 years were included. Group 1: children using antiepileptic drugs that cause cytochrome P450 enzyme induction; Group 2: those using antiepileptic drugs that cause inhibition; and Group 3: those that did not use antiepileptic drugs. Sedation was induced with the use of 0.05 mg kg(-1) midazolam and 1 mg kg(-1) propofol. An additional 0.05 mg kg(-1) of midazolam and rescue propofol (0.5 mg kg(-1)) were administered and repeated to maintain sedation. The duration of sedation and the additional sedation needed were compared. Results: The duration of the initial dose was significantly shorter in Group I compared with groups II and III (p = 0.001, p = 0.003, respectively). It was significantly longer in Group II compared with groups I and III (p = 0.001, p = 0.029, respectively). The additional midazolam needed for adequate sedation was increased in Group I when compared with groups II and III (p = 0.010, p = 0.001, respectively). In addition, the rescue propofol dose was significantly higher only in Group I when compared with Group III (p = 0.002). Conclusion: In epileptic children, the response variability to the initial sedative agents during the magnetic resonance imaging procedure resulting from the inhibition or induction of the cytochrome P450 isoenzymes by the antiepileptic drugs mandated the titration of anesthetic agents. Copyright (C) 2013 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.Öğe Intrathoracic Rib Associated with Pulmonary Collapse in a Pediatric Patient(Kowsar Publ, 2012) Basarslan, Fatmagul; Bayarogullari, Hanifi; Tutanc, Murat; Arica, Vefik; Yilmaz, Cahide; Davran, RamazanThe ribs are essential structures of the osseous thorax that provide certain significant information and aid interpretation of radiologic images in daily routine practice. Intrathoracic rib is a rare congenital anomaly that is usually discovered incidentally, but may cause in vain interventions in case of being unaware. We herein report an intrathoracic rib in a girl whose chest X-ray was strange enough to obtain a spiral computed tomography (CT) scanning for a definitive diagnosis afterwards.Öğe Magnetic Resonance Imaging Findings of the Abducens Nerves in Type 1 Duane's Retraction Syndrome(Taylor & Francis Inc, 2014) Tuzcu, Esra Ayhan; Bayarogullari, Hanifi; Atci, Nesrin; Basarslan, Fatmagul; Coskun, Mesut; Yilmaz, Cahide; Ilhan, NiluferPurpose: To investigate nervus abducens and extraocular mucles in patients with Type 1 Duane's retraction syndrome using high-definition magnetic resonance imaging. Methods: The study included 10 patients with Type I Duane's retraction syndrome who underwent magnetic resonance imaging (MRI) of the brain and orbits. Results: Overall, 10 cases were included in the study. There were seven women and three men. The mean age was 5.2 years (1-15 years). MRI of the abducens nerve was performed in all cases. Of the cases, the left eye was involved in eight cases, whereas the right eye was involved in two cases. There was no bilateral eye involvement. Among the 10 patients clinically diagnosed as Type 1 Duane's retraction syndrome, the abducens nerve could not be visualized in eight cases, whereas the nerve was hypoplastic in one case and bilateral abducens nerves were present in one case by MRI. The extraocular muscles were normal in all cases on T2 weighted coronal MRI of the orbits. Conclusion: Absence of abducens nerve and normal extraocular muscles was detected in patients with Type 1 Duane's retraction syndrome at the affected side.Öğe Protective effects of N-acetylcysteine on triamcinolone acetonide-induced lens damage in rats(Taylor & Francis Ltd, 2014) Tuzcu, Esra Ayhan; Tuzcu, Kasim; Basarslan, Fatmagul; Motor, Sedat; Coskun, Mesut; Keskin, Ugurcan; Ayintap, EmreObjective: To examine the relationship of cataract forming effect of intravitreal triamcinolone acetonide (IVTA) injection with oxidative status and the effect of N-acetylcysteine (NAC) on these alterations. Materials and methods: Twenty-six Wistar-Albino rats were included in the study. Rats were assigned into four groups as follows: intravitreal saline injection group (controls); IVTA injection group; IVTA + intraperitoneal NAC injection group (IVTA + NAC); and intraperitoneal NAC injection group (NAC). Triamcinolone acetonide was intravitreally injected at a dose of 1 mg. NAC was intraperitoneally injected at a dose of 150 mg/g body weight. Animals were sacrificed and lens specimens were analyzed for levels of malondialdehyde (MDA) and protein carbonyl (PC) and activities of glutathione (GSH) and glutathione peroxidase (GSH-Px). Results: We found that the MDA and PC levels of lenses were increased in the IVTA group (p < 0.01). It was seen that GSH and GSH-Px in lenses were decreased in the IVTA group (p < 0.01). NAC administration significantly ameliorated these changes in the IVTA + NAC group (p<0.05). Conclusion: These results indicate that the NAC produces a protective mechanism against IVTA-induced cataract and suggest a role of oxidative stress in pathogenesis.Öğe TYPE 1 CROUZON SYNDROME WITH HEADACHE(Nobel Ilac, 2013) Arica, Vefik; Tutanc, Murat; Bayarogullari, Hanifi; Arica, Secil Gunher; Basarslan, Fatmagul; Davran, Ramazan; Korkmaz, InanCrouzon syndrome defined by French neurosurgeon Crouzon in 1912. Crouzon syndrome which is characterized by craniosynostosis and dysmorphic facial appearance. This autosomal dominant disease has an incidence rate of 16/1,000,000. Craniosynostosis premature closure of cranial sutures, results in craniofacial anomalies. 4.5% of cases with craniosynostosis have Crouzon syndrome. Craniosynostosis can occur in utero or in the first three years of life. It rarely occurs later Phenotypically specific types of craniosynostosis have been linked to fibroblast growth factor receptor gene (FGFR) mutations. Clinical findings of Crouzon, Apert and Pfeifer syndromes are secondary to FGFR-2 gene mutations. In Crouzon syndrome brachycephaly, ptosis, exophthalmos, hypertelorism, acanthosis nigricans, rostrate type nose, ear and palate anomalies can occur of as a result of premature closure of cranial sutures. In this report we present a 5 years old male with headache. He has Crouzon Syndrome and beaten copper appearance in craniography.Öğe The youngest patient of lupus vulgaris; A cutaneous tuberculosis case report(Professional Medical Publications, 2012) Tutanc, Murat; Arica, Vefik; Basarslan, Fatmagul; Dogramaci, Asena Cigdem; Ozgur, Tumay; Akcora, BulentTuberculosis, which may involve most organs, is still a major health problem in developing countries. Despite a high and increasing frequency of tuberculosis, cutaneous tuberculosis (CT) is an uncommon form. CT may develop due to Mycobacterium tuberculosis, Mycobacterium bovis, and the Bacille Calmette-Guerin (BCG). CT may have various clinical forms. The most frequent form of CT is lupus vulgaris (LV). LV originates from inactive tuberculosis focus in the body and spreads by hematogenous or lymphatic way and by direct or exogenous inoculation. A diagnosis of LV was made based on clinical and histopathological examination. The lesions regressed after treatment with 3 antituberculous drugs. CT must be considered in cases with chronic skin lesions because tuberculosis prevalence is high in our country. Early diagnosis and treatment of patients with CT is extremely important in order to prevent complications. We report, to the best of our knowledge, the youngest CT affecting case.
