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    Öğe
    EVALUATION OF THE IN VITRO AND IN VIVO EFFECTS OF THE ETHANOLIC LYOPHILIZED EXTRACT OBTAINED FROM PHOLIOTA AURIVELLA MUSHROOM ON CCI4-INDUCED TOXICITY IN RATS
    (Parlar Scientific Publications (P S P), 2019) Dogan, Abdulahad; Dalar, Abdullah; Battal, Abdulhamit; Uyar, Ahmet; Sadullahoglu, Cemil; Celik, Ismail; Uzun, Yusuf
    The aim of this study was to evaluate Pholiota aurivella extract's chemical and mineral composition, total antioxidant capacity, histopathological changes in liver and kidney, as well as its possible protective/harmful role against carbon tetrachloride (CCl4)-induced oxidative stress in rats. After the toxicity test, twenty four rats were divided into four experimental groups: Control, CCl4, CCl4+P. aurivella (100 mg/kg, extract) and CCl4+P.aurivella (500 mg/kg, extract) groups. Some biochemical parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) in serum, malondialdehyde (MDA) and antioxidant defense system (ADS) constituents such as reduced glutathione (GSH) levels, glutathione reductase (GR), glutathione S-transferase (GST), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) activities in the liver, brain and kidney tissues, histopathological changes in liver and kidney of rats were observed. P.aurivella extract was rich in phenolic (p-coumaric and protocatechuic acids) and fatty acid (linoleic, oleic and palmitic acids) compounds and high level of Arsenic. In vivo studies revealed that P.aurivella extract suppressed the levels of ADS enzymes and increased the MDA content and AST, ALT and LDH in treated groups. According to histopathological investigation, liver and kidney revealed severe histopathological changes both in CCl4 group and P.aurivella- treated groups. These results have shown that oral administration of P. aurivella extract caused a significant toxic effects in rats. Therefore, in the context of the data obtained from this study the P. aurivella could not be regarded as a safe food source.
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    Öğe
    Exploring of the ameliorative effects of Nerium (Nerium oleander L.) ethanolic flower extract in streptozotocin induced diabetic rats via biochemical, histological and molecular aspects
    (Springer, 2023) Battal, Abdulhamit; Dogan, Abdulahad; Uyar, Ahmet; Demir, Abdulbaki; Keles, oemer Faruk; Celik, Ismail; Baloglu, Mehmet Cengiz
    Background Nerium oleander L. is ethnopharmacologically used for diabetes. Our aim was to investigate the ameliorative effects of ethanolic Nerium flower extract (NFE) in STZ-induced diabetic rats.Methods Seven random groups including control group, NFE group (50 mg/kg), diabetic group, glibenclamide group and NFE treated groups (25 mg/kg, 75 mg/kg, and 225 mg/kg) were composed of forty-nine rats. Blood glucose level, glycated hemoglobin (HbA1c), insulin level, liver damage parameters and lipid profile parameters were investigated. Antioxidant defense system enzyme activities and reduced glutathione (GSH) and malondialdehyde (MDA) contents and immunotoxic and neurotoxic parameters were determined in liver tissue. Additionally, the ameliorative effects of NFE were histopathologically examined in liver. mRNA levels of SLC2A2 gene encoding glucose transporter 2 protein were measured by quantitative real time PCR.Results NFE caused decrease in glucose level and HbA1c and increase in insulin and C-peptide levels. Additionally, NFE improved liver damage biomarkers and lipid profile parameters in serum. Moreover, lipid peroxidation was prevented and antioxidant enzyme activities in liver were regulated by NFE treatment. Furthermore, anti-immunotoxic and anti-neurotoxic effects of NFE were determined in liver tissue of diabetic rats. Histopathogically, significant liver damages were observed in the diabetic rats. Histopathological changes were decreased partially in the 225 mg/kg NFE treated group. SLC2A2 gene expression in liver of diabetic rats significantly reduced compared to healthy rats and NFE treatment (25 mg/kg) caused increase in gene expression.Conclusion Flower extract of Nerium plant may have an antidiabetic potential due to its high phytochemical content. [Graphics] .