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Öğe Accuracy and reliability of enamel and dentin thickness measurements on micro-computed tomography and digital periapical radiographs(Elsevier, 2019) Belgin, Ceren Aktuna; Serindere, Gozde; Orhan, KaanIn the application of scientific human skeletal variation in medico-legal matters, virtual anthropology is the current technique performed to examine skeleton and its body parts. Digital imaging techniques are used in many areas of dentistry and forensic dentistry. Among all digital imaging modalities, digital periapical radiography (PR) are the most widely used, however, new contemporary imaging techniques micro-computed tomography (Micro-CT) can be also used. The aim of this study was to assess the accuracy and reliability of enamel and dentin thickness measurement through intra and inter-observer error analysis, and comparison was made between periapical radiographs and Micro-CT methods. In this study 15 maxillary first premolar were used which extracted for various reasons. Enamel and dentin thicknesses and maximum cervical crown widths (MCCW) of 15 premolar teeth were examined in both Micro-CT and periapical radiographs. The results obtained with the exact maximum cervical crown widths were compared Image J software version. A digital caliper was used to measure the actual MCCW of the teeth. Results exhibited no significant differences in the measurements by the intra or inter-observer error analyses. The intraclass correlation coefficients (ICC) were more than 0.95 by both intra and inter-observer error analyses. There was significant differences in the measurements by PR and Micro-CT methods. By parameters, Micro-CT showed the highest R value (0.962) with the least error in different methods and observers. In conclusion, dentin and enamel measurements by Micro-CT was highly accurate and reliable as in the conventional method (PR). Micro-CT evaluations should be recommended for implementation in the future anthropological studies especially in countries with limited source of dental data.Öğe Assessment of apical periodontitis in relation to quality of root canal fillings and coronal restorations in a Turkish subpopulation: A retrospective cone-beam computed tomography study(Wolters Kluwer Medknow Publications, 2020) Falakaloglu, Seda; Belgin, Ceren Aktuna; Uygun, Latife Altnok; Adigözel, OzkanIntroduction: This study aims to investigate the prevalence of apical periodontitis (AP) and relate the quality of root canal fillings (RCFs) and coronal restorations (CRs) with using cone-beam computed tomography (CBCT) in a Turkish subpopulation. Materials and Methods: A total of 824 CBCT scans were performed at the Dicle University Faculty of Dentistry between January 2015 and December 2017. The age, sex, root canal-Treated teeth of each patient, quality of RCF and CR, and CBCT periapical index (CBCTPAI) scores of teeth were calculated and recorded. Data were statistically analyzed. Results: Among 333 patients, 152 (45.6%) patients were male and 181 (54.3%) were female. The mean age was 30.1 ± 5.3 years. The total number of endodontically treated teeth was 550, and 76.2% had AP. In 238 (43.3%) teeth with inadequate RCF, AP rate was 89.4%. There was a significant correlation between the density of the RCF and AP (P < 0.00). Inadequate restorations accounted for 177 teeth (32.2%), of which 10.1% (18) of the teeth were CBCTPAI 1. Of the 41 teeth with missing CR, 39 (95.1%) teeth showed signs of AP. A significant difference was found between CR and AP (P = 0.00). Conclusions: The RCF quality, adequate CR, and the type of CR are related to AP. © 2020 Saudi Endodontic Journal | Published by Wolters Kluwer - Medknow.Öğe COMPARISON OF MANUAL AND SEMIAUTOMATIC SEGMENTATION METHODS FOR CALCULATING FRONTAL AND SPHENOID SINUS AREA AND VOLUME USING OF COMPUTED TOMOGRAPHY(2021) Belgin, Ceren Aktuna; Serindere, GözdeObjective: To compare the effectiveness of the manual and semi-automatic segmentation modules of the third-generation software used in computedtomography (CT) images in calculating frontal sinus (FS) and sphenoid sinus (SS) areas and volumes.Methods: CT images of 200 patients (96 female, 104 male) between the ages of 19 and 73 years (mean 37.38 ± 16.32 years) were randomly selected.Volume and area of FS and SS were segmented manually and semi-automatically using InVesalius 3.1.1 software (CTI, Campinas, São Paulo,Brazil).Results: There was a statistically significant difference was found the main SS area in manual mode and semi-automatic mode as 4.80 ± 1.86 $cm^2$ and 4.84 ± 1.83 $cm^2$, respectively. The main SS volumes were in manual mode and semi-automatic mode as 8.44 ± 3.55 $cm^3$and 9.62 ± 3.21 $cm^3$, respectively. The main FS volumes were in manual mode and semi-automatic mode as 5.32 ± 2.04 $cm^3$ and 6.65 ± 2.70 $cm^3$, respectively. There was a statistically significant difference was found between manual mode and semi-automatic mode in volume calculation (p<0.05).Conclusion: It was seen that the values measured in both segmentations are close to those presented in the mean literature data, however, whenusing the semi-automatic segmentation module, it should be ensured that the formations other than the structure to be evaluated are not included inthe measurement.Öğe Comparison of Ultrasonography and Cone Beam Computed Tomography in the Differential Diagnosis of Periapical Lesions: A Prospective Radiopathological Study(Univ Indonesia, Fac Dentistry, 2022) Serindere, Gozde; Belgin, Ceren Aktuna; Bulte, Mert; Gursoy, Didar; Salimov, FarizObjective: The aim of this study is to evaluate the correlation between ultrasonography (USG) and cone beam computed tomography (CBCT) and the accuracy between histopathological diagnosis and preliminary diagnosis in the diagnosis of periapical lesion. Methods: 20 patients with periapical lesion in the jaw, were included in the study. The presence of expansion or perforation and dimensions of the lesion were performed with CBCT. In the examination of the lesion with USG, shape, echogenicity, vascularization of the lesion and the presence of buccal expansion and perforation, were determined. Subsequently, a biopsy was taken from the lesion for histopathological examination and the final result was compared with the accuracy of the preliminary diagnoses. Results: Kolmogorov-Smirnov test, Wilcoxon test (w) and Cohen's kappa coefficient (kappa) was used to analyze the data. Three of the 4 lesions diagnosed as periapical granuloma as a preliminary diagnosis were confirmed as periapical granuloma in histopathological examination. Periapical cyst was confirmed in histopathological examination of 14 of 16 lesions diagnosed as periapical cyst as a preliminary diagnosis. Mesiodistal (MD) measurements in CBCT measurements were significantly higher than the USG group (p <0.05). There was 100% agreement (p = 0.000) between the evaluation of buccal expansion, buccal perforation, and palatal-lingual perforation between CBCT and USG. Conclusion: It was concluded that the combined use of USG and CBCT can provide the clinician with important information in the diagnosis of periapical lesion.Öğe Determination of alveolar bone height according to the relationship between molar teeth and maxillary sinus(Springer Heidelberg, 2021) Belgin, Ceren Aktuna; Bayrak, Seval; Atakan, CemalPurpose This study aims to analyze alveolar bone height (ABH) in the maxillary molar area according to the anatomical relationship between maxillary sinus and maxillary molar teeth via cone beam computed tomography images. Methods In 330 patients, 660 maxillary first molar (M1) and 648 maxillary second molar (M2) were evaluated. ABH measurements were made as to the shortest distance between the furcation midpoints of maxillary molars and the lowest point of the sinus floor. After the measurement, the positions of the maxillary molar teeth relative to the maxillary sinus were classified into four categories as type 1, 2, 3, and 4. Results ABH measurements in males were significantly higher than females (p< 0.05), but there were no differences between sides (p> 0.05). There were significant differences between types of both M1 and M2 for ABH, and the longest ABH was measured in type 1 (p< 0.05). Type 3 was the most common among 1308 maxillary molars teeth followed by type 1, type 2, and type 4. Conclusion Determination of the relationship between maxillary molar teeth and the maxillary sinus and analysis of ABH according to this relationship may help plan endodontic treatment, apical surgery, and immediate implant therapy and prevent their complications.Öğe Determining the reliability of diagnosis and treatment using artificial intelligence software with panoramic radiographs(Korean Acad Oral & Maxillofacial Radiology, 2023) Orhan, Kaan; Belgin, Ceren Aktuna; Manulis, David; Golitsyna, Maria; Bayrak, Seval; Aksoy, Secil; Sanders, AlexPurpose: The objective of this study was to evaluate the accuracy and effectiveness of an artificial intelligence (AI) program in identifying dental conditions using panoramic radiographs (PRs), as well as to assess the appropriateness of its treatment recommendations. Materials and Methods: PRs from 100 patients (representing 4497 teeth) with known clinical examination findings were randomly selected from a university database. Three dentomaxillofacial radiologists and the Diagnocat AI software evaluated these PRs. The evaluations were focused on various dental conditions and treatments, including canal filling, caries, cast post and core, dental calculus, fillings, furcation lesions, implants, lack of interproximal tooth contact, open margins, overhangs, periapical lesions, periodontal bone loss, short fillings, voids in root fillings, overfillings, pontics, root fragments, impacted teeth, artificial crowns, missing teeth, and healthy teeth. Results: The AI demonstrated almost perfect agreement (exceeding 0.81) in most of the assessments when compared to the ground truth. The sensitivity was very high (above 0.8) for the evaluation of healthy teeth, artificial crowns, dental calculus, missing teeth, fillings, lack of interproximal contact, periodontal bone loss, and implants. However, the sensitivity was low for the assessment of caries, periapical lesions, pontic voids in the root canal, and overhangs. Conclusion: Despite the limitations of this study, the synthesized data suggest that AI-based decision support systems can serve as a valuable tool in detecting dental conditions, when used with PR for clinical dental applications.Öğe Evaluation of bone change in smokers and ex-smokers using fractal analysis and lacunarity analysis(Elsevier Science Inc, 2024) Belgin, Ceren Aktuna; Serindere, Gozde; Hammudioglu, Zarif EceObjective: It is known that smoking causes many diseases such as oral and nasopharyngeal cancers, cardiovascular diseases and osteoporosis. With fractal analysis (FA), changes in trabecular bone can be detected. The cavities in the bone can also be evaluated with the lacunarity analysis (LA). In the light of this information, the aim of this study is to investigate how the duration of smoking and the duration of smoking cessation affect bone change in the mandible using FA and LA. Methods: Panoramic radiographs (PR) of 140 patients were grouped according to the duration of smoking and the duration of smoking cessation. The changes in the mandibular bone were evaluated with both FA and LA, and the results were compared with the control group who never smoked. Kolmogorov-Smirnov test, Mann -Whitney U test and Spearman correlation analysis was used in the analysis. Results: The smokers ' FA value was significantly lower than the control group and the ex -smokers group. The smokers ' LA value was significantly higher than the control and ex -smokers ' group. The ex -smokers ' FA value was significantly lower than the control group. Both FA and LA values did not differ significantly between the genders. No significant correlation was observed between both FA and LA values and age. Conclusions: FA values were lower and LA values were higher in smokers. It is thought that in smokers, the trabeculation in the bone decreases and accordingly the intraosseous spaces increase, and the duration of smoking and quitting also affects the internal structure of the bone. PR can be used to evaluate bone structure with FA and LA analysis.Öğe Evaluation of canalis sinuosus and accessory canal morphology by cone-beam computed tomography(Springer, 2024) Belgin, Ceren Aktuna; Serindere, Gozde; Hammudioglu, Zarif Ece; Kucuk, MerveObjectiveTo evaluate canalis sinuosus (CS) and accessory canalis sinuosus (AC) morphology and their relationship with the impacted canine on cone-beam computed tomography (CBCT) images.MethodsThe diameter and location of the CS, its distance from the nasal cavity (NC-CS), its distance from the buccal cortical plate (BC-CS), and its distance from the alveolar ridge crest (AR-CS) were evaluated on 1000 CBCT scans. The prevalence and termination of AC and the presence of impacted canines were also evaluated.ResultsCS was detected in 89 (8.9%) of 1000 CBCTs. The mean CS diameter was found as 1.34 +/- 0.53 mm. No statistically significant difference was found between gender, age, direction, and CS presence and diameter. CS was most frequently seen in regions 11 (23.6%) and 13 (23.6%). The average NC-CS, BC-CS, and AR-CS length was 6.14, 6.06 and 4.35 mm, respectively. AC was detected in 22 patients (24.71%). There was no statistically significant difference between the presence of AC and gender, age, CS diameter, NC-CS, BC-CS, and AR-CS distance. BC-CS length and AR-CS length were statistically significantly higher in patients with impacted canines.ConclusionsIt should be kept in mind that the CS diameter, NC-CS, BC-CS, and AR-CS distance may increase in the presence of an impacted canine and the integrity of the neurovascular structure should be preserved. The fact that the CS is often localized in the palatial region requires a detailed evaluation of the anterior maxillary region with three-dimensional imaging methods.Öğe Evaluation of the Effect of Ultrasonic and Sonic Activation Systems on Root Canal Filling Quality in Resin Primary Molars: in vitro Study(2024) Topal, Burcu Güçyetmez; Falakaloğlu, Seda; Akgül, Esra Nur; Belgin, Ceren AktunaObjective: The aim of this study is to evaluate the effect of different filling methods on canal filling quality in resin primary molar teeth prepared with two different preparation techniques. Mate- rial and Methods: For the study, 60 maxillary primary second molar teeth obtained from resin block were used. Root canals were prepared using a manual #K-file (n=30) and a VDW Rotate™ System (n=30) rotary instrument. Each group was divided into 3 subgroups according to the filling technique used (n=10): Calci-Paste ® syringe (control group); Calci-Paste ® syringe and Uc-One ® (ultrasonic activation); Calci-Paste® syringe and Eddy ® (sonic activation). The quality of the canal filling (under filled, optimal filled, overfilled) and the pres- ence/absence of voids were assessed using cone beam computed to- mography. SPSS (Statistical Package for Social Science, IBM SPSS®, version 26, Chicago, USA) program was used for statistical analysis. Results: There was no significant difference between the different preparation and filling techniques in terms of filling volume and length, In the study, voids were detected in all three filling methods, but the highest void filling was found in the Calci-Paste ® syringe +ultrasonic activation group (48%). The manual preparation and syringe group had the most optimally filled teeth but there was no significant difference between the groups (For preparation methods p=0.573; for filling meth- ods p=0.976). Conclusion: In this study, it was found that sonic and ul- trasonic systems did not improve the quality of root canal filling in resin primary molars and ultrasonic activation caused more voids.Öğe Evaluation of The Ethmoid Bone Using by Cone Beam Computed Tomography In Turkish Subpopulation(Marmara Univ, Inst Health Sciences, 2021) Belgin, Ceren Aktuna; Bayrak, Seval; Orhan, KaanObjective: The objective of this retrospective study was to evaluated anatomical structures of ethmoid bone on cone beam computed tomography (CBCT) images in a Turkish subpopulation. Methods: The CBCT images of 200 patients (116 female and 84 male), between the age of 18 and 50 years, who met the study criteria were selected randomly. The medial ethmoid roof height (MERH), cribriform plate height (CP), the height of the lateral lamella of the cribriform plate (LLCP) were measured. All the data were grouped by age, side, and gender. Results: For MERH; the mean heights for the left and the right side were 25.55 +/- 3.00 mm and 25.24 +/- 3.01 mm, respectively. There was no significant difference between right MERH and genders (p>0.05). The mean LLCP heights on the right and left sides were 4.98 +/- 2.12 mm and 4.49 +/- 1.64 mm, respectively. It was found that LLCP height did not have a statistically significant correlation with gender (p>0.05). The average of right and left CPH were calculated 20.55 +/- 2.61 mm and 20.82 +/- 2.75 mm, respectively. Both the right and left CPH were significantly higher in males (p<0.05). Also, there was no correlation between the height of the anatomical structures of the evaluated ethmoid bone and the increase or decrease in age (p>0.05). Conclusion: Morphological differences in the anatomy of ethmoid bone were shown in this study. The anatomical structures showing changes due to factors such as side, age, gender, and race should be examined in three dimensions before the operation.Öğe An evaluation of the relationship between maxillary sinus anterior wall depression and maxillary sinus opacity by computed tomography and panoramic radiography(Springer, 2020) Serindere, Gozde; Belgin, Ceren AktunaObjective Maxillary sinus anterior wall depression (AWD) has been associated with patterns such as the presence of panoramic innominate line and silent sinus syndrome. The aim of this study was to evaluate the relationship between AWD of maxillary sinus and both maxillary sinus opacity and the presence of innominate line using computed tomography (CT) and panoramic radiography (PR). Materials and methods 250 CT and PR images (122 female, 128male) which had been taken for various reasons were randomly selected from the radiology archive of the our department. Innominate line visibility in PR is divided into three as invisible, obscure and clear. On CT images, the distance between guide line and the deepest point of the maxillary sinus anterior wall was calculated as AWD. The presence of maxillary sinus opacity and maxillary sinus AWD were evaluated on CT images. Demographic information such as age, gender and localization of the findings were noted in all measurements. Results In 143 (57.2%) patients, the innominate line (clear and obscure patterns) was seen on the PR images. AWD was observed in 104 (41.6%) CT images. The presence of maxillary sinus opacity was observed in 117 (46.8%) images. The mean right anterior wall depth was 5.69 and 4.88 in males and females, respectively, while the mean left anterior wall depth was 5.64 and 4.94 in males and females, respectively. Right wall depth was significantly higher in males (p < 0.05).There was no statistically significant difference in left wall depth (p > 0.05). Conclusions Anterior wall depression was found to be associated with both maxillary sinus opacity and the visibility of the innominate line. Patients with AWD should be considered as susceptible to maxillary sinus diseases.Öğe Evaluation of the Relationship Between Olfactory Fossa Measurements and Nasal Septum Deviation for Endoscopic Sinus Surgery(Lippincott Williams & Wilkins, 2020) Bayrak, Seval; Belgin, Ceren Aktuna; Orhan, KaanIntroduction: Endoscopic sinus surgeries (ESS) are frequently used in the treatment of optic nerve decompression, other intracranial lesions and sinonasal pathologies. The olfactory fossa can be localized on different levels in relation to the anterior cranial fossa. The aim of the present study was to evaluate the depth and width of the olfactory fossa (OF) in relation to nasal septum deviation (NSD). Methods: A total of 225 patient (141 female and 84 male, age range between 15 to 56 years) of cone beam computed tomography (CBCT) data was used in this study. NSD, OF width, OF depth were measured. OF depth which was grouped according to the Keros classification as Type I, II, and III was calculated. All measurements were performed bilaterally except for NSD. Results: In the right and left OF depth were found Keros Type I 32 (14.2%) and 30 (13.3%), Keros Type II 171 (76%) and 167 (74.2%), and Keros Type III 22 (9.8%) and 28 (12.4%) respectively. There was no statistically significant found between OF depth and NSD (P > 0.05). The mean angle of the NSD in men and women were 4.36 +/- 4.69(o)in women 4.11 +/- 4.36(o), respectively. The mean width of the right OF was 2.50 +/- 0.64 mm and 2.58 +/- 0.72 mm for the left side and there was no statistically significant association between OF width - NSD and OF width - OF depth (P > 0.05). Conclusion: The anatomy of the OF should be well established before surgical intervention increase of the length of the lateral lamella is also increases the risk of developing complications such as cerebral damage, hemorrhage, and cerebrospinal fluid fistula during endoscopic sinus surgery. Although there is no significant difference between OF measurement and NSD, with three-dimensional imaging detailed research is required before endoscopic sinus surgical operations.Öğe Evaluation of the relationship between sphenoid sinus morphology and area and volume by computed tomography(Springer, 2024) Serindere, Mehmet; Belgin, Ceren AktunaObjectivesThe aim of this study is to investigate the effect of sphenoid sinus pneumatization types, Onodi cell (OC), internal carotid artery (ICA), optic nerve (ON) on sinus volume and area on computed tomography (CT) images.MethodsThe CT images of 150 patients were evaluated. Sphenoid sinus pneumatization types, OC prevalence, protrusion and dehiscence of ICA and ON, the volume and area were evaluated.ResultsThe sinus volume and area were statistically higher in patients with bilateral protrusion of ICA and ON then patients without protrusion of ICA and ON. The mean volume and area of sinus were 9949.4 & PLUSMN; 351.0 mm3 and 4570.9 & PLUSMN; 1604.9 mm2, respectively. The volume and area of sphenoid sinus did not differ significantly between groups with and without OC. The postsellar b type sphenoid sinus had the highest volume, while conchal type has the least volume.ConclusionsBilateral protrusion and dehiscence of ICA and bilateral protrusion of ON caused a significant increase in the sphenoid sinus volume and area. The presence of ICA and ON, the pneumatization of the sinus is an anatomical structure that can affect the sinus volume and area. Before the operation, three-dimensional evaluation should be performed to determine whether these structures are bilateral/unilateral and it should be remembered that the sinus volume and area can change.Öğe Evaluation of the visibility of peri-implant bone defects using ultrasonography with two types of probes(Medical Communications, 2021) Orhan, Kaan; Serindere, Gozde; Belgin, Ceren Aktuna; Kurt, Mehmet HakanBackground: The aim of the present study was to evaluate the efficacy of intraoral and extraoral ultrasonography evaluations performed with two different types of probes (linear and hockey stick) for the visibility of peri-implant bone defects. Material and methods: Fourteen implants were inserted into sheep heads. Peri-implant bone defects were created without knowing the depth, which served as the gold standard for the defects. The defects were scanned with two different probe types (linear and hockey stick probes) extraorally and intraorally, using two different ultrasonography systems. For intra- and interobserver agreements for each probe types, Kappa coefficients were calculated. Results: The lowest ICC values were found in both intra- (ICC = 0.696) and interobserver reliability (ICC = 0.762) obtained with the extraorally used linear probe. There was a high agreement with the gold standard when using hockey sticky probes intraorally. For both linear probes, there were no significant differences in agreement among the two observers and the gold standard (p >0.05). Conclusions: High agreement was found when using high-frequency hockey stick probes intraorally, which means that they can be used with good effect for the evaluation of the visibility of peri-implant bone defects. To the best of our knowledge, this study is the first one on this subject. Thus, it can be stated that US can be an alternative method of examining defects. However, further studies are needed to evaluate the effectiveness of US in visualizing peri-implant bone defects.Öğe Evaluation of trabecular bone changes in patients with periodontitis using fractal analysis: A periapical radiography study(Wiley, 2020) Belgin, Ceren Aktuna; Serindere, GozdeBackground The present study was aimed to evaluate the trabecular bone changes between healthy individuals and periodontitis patients with fractal dimension analysis on digital periapical radiographs. Methods Data from 35 healthy and 35 individuals with periodontitis were confirmed from the database of our faculty and included in the study. Two regions of interest (ROI) were selected belonging to mesial and distal region of mandibular first molar on periapical radiographs. The mean fractal dimension (FD) values of two regions were calculated with using box-counting method. Student t test was used for the comparison of the FDs. Results The mean FD of individuals with periodontitis was 0.97, whereas it was 1.04 for the healthy group. The mean FD values were significantly higher in the healthy group (P < 0.05). In the periodontitis group, as the FD of mesial interdental bone increased, the FD of distal interdental bone increased significantly (P < 0.05). Conclusion Because of FD numerically showing changes in bone trabeculation, changes in the alveolar bone can be detected quantitatively.Öğe Fractal and radiomorphometric analysis of mandibular bone changes in patients undergoing intravenous corticosteroid therapy(Elsevier Science Inc, 2020) Belgin, Ceren Aktuna; Serindere, GozdeObjective. To evaluate mandibular bone changes by comparing the fractal dimension (FD), mandibular cortical width (MCW), and panoramic mandibular index (PMI) on panoramic radiographs in patients using intravenous corticosteroids versus controls. Study Design. In total, 60 patients were divided into 2 groups: 30 patients receiving intravenous corticosteroid treatment and 30 age- and sex-matched healthy people as the control group. Panoramic radiographs of all patients were evaluated. FD was measured in 4 regions: the subcortical area in the condyle, the area superior to the angle of the mandible, the alveolar bone distal to the mandibular left second premolar root, and the alveolar bone mesial to the mental foramen. MCW and PMI were calculated to assess cortical thickness. Results. The FD values in the condyle, angle of the mandible, and mental foramen region were significantly lower in the corticosteroid group (P <= .011), but there was no significant difference in the second premolar area (P = .101). MCW values were significantly lower in the corticosteroid group (P < .001). There was no significant difference in PMI between the groups (P = .544). Conclusions. The FD and MCW values of the patients using corticosteroids can be helpful in quantitatively and objectively evaluating osseous changes in patients receiving intravenous corticosteroids.Öğe Investigation of the Effect of Linoleic Acid on Vascularization in Experimentally Induce Zoledronic Acid-Related Osteonecrosis in Rats(2021) Yurtal, Ziya; Serindere, Gözde; Belgin, Ceren Aktuna; Takcı, LutfiBisphosphonate-related osteonecrosis of the jaw (BRONJ) is an increasingly common pathological condition whose pathophysiology is not fully understood and can be difficult to manage. The unique biological effects of conjugated linoleic acid (CLA) include angiogenic, anticarcinogenic, antiatherosclerotic, antioxidative, immunomodulative and antibacterial effects. The aim of this study is to compare the osteonecrosis areas created by tooth extraction with the control group using scanning electron microscopy (SEM) after the administration of zoledronic acid (ZA), CLA and a combination of both in the rat jaw. A total of 50 Wistar Albino male rats weighing 400-450 grams were used. The groups were randomly divided into 5 groups: the control group, the sham group, the group that received ZA, the groups that received CLA with ZA (100 mg / kg and 200 mg / kg), and the study lasted a total of 10 weeks. Regardless of the use of ZA, it was observed by SEM that vascularization was impaired in all groups with tooth extraction. Neovascularization did not occur in the groups where CLA was applied, regardless of the dose. It was concluded that SEM analysis and corrosion casts technique can be considered as an alternative method in such studies due to its accessibility and low cost in observing dental vascularization. However, no definite conclusion could be reached about the neovascularization efficiency of CLA within the period evaluated after tooth extraction.Öğe MRI investigation of TMJ disc and articular eminence morphology in patients with disc displacement(Elsevier, 2021) Serindere, Gozde; Belgin, Ceren AktunaPurpose: The aim of this study was to evaluate the morphology of the temporomandibular joint (TMJ) articular eminence and disc and the relationship between morphology and inclination in patients with disc displacement. Methods: TMJ magnetic resonance images (MRI) of 30 patients with disc displacement with reduction (DDWR) on one side and disc displacement without reduction (DDWOR) on the other side were analyzed. Articular eminence morphology was subdivided as box, sigmoid, flattened and deformed. Articular disc configuration was characterized as biconcave, biplanar, biconvex, hemiconvex and folded. The articular eminence inclination was measured as the angle between the Frankfurt plane and a line drawn from the glenoid fossa roof to the lowest point of the articular eminence. Results: Regarding articular eminence shape, in both DDWR and DDWOR groups, the most frequent articular eminence shape was flattened shape. Regarding to the disc morphology, biplanar shape was the most frequently observed in both DDWR side and DDWOR side. The mean articular eminence inclination was 32.62 and 33.85 in the DDWR and DDWOR side, respectively. Conclusions: Disc and articular eminence morphology was found to have no relationship with TMJ internal derangement except the relationship between flattened type and internal derangement. The articular eminence inclination have no influence on disc reduction. (C) 2020 Elsevier Masson SAS. All rights reserved.Öğe Multiple Regression Modeling for Age Estimation by Assessment and Comparison of Spheno-Occipital Synchondrosis Fusion and Cervical Vertebral Maturation Stages(Thieme Medical Publ Inc, 2022) Belgin, Ceren Aktuna; Bayrak, Seval; Orhan, Kaan; Ankarali, HandanObjectives The aim of this study was (1) to evaluate the relationship between spheno-occipital synchondrosis (SOS) fusion stages, cervical vertebral maturation (CVM) stages, and clivus sizes with chronological age on cone-beam computed tomography (CBCT) images, and (2) to compare these methods for accurate age estimation using regression analysis. Materials and Methods The CBCT images of 200 individuals (102 females and 98 males) were included in the study. The SOS fusion stages and CVM stages were evaluated. The width and length of the clivus were measured. The effects of SOS fusion stages, CVM stages, clivus width, and clivus length on age estimation were evaluated by univariate tests and the effects of coexistence with ANCOVA and regression model. Spearman rank correlation analysis was also used to investigate the relationship between the SOS fusion stage, CVM stage, clivus width, and clivus length. Results The SOS stages, CVM stages, and clivus width were not shown statistically significant differences between the sexes (p-values=0.205, 0.162, and 0.277, respectively), whereas clivus length was significantly longer in males (42.94.26mm) than in females (41.04 +/- 3.74mm). Multiple regression analysis showed 80% success when all parameters (SOS fusion stages, CVM stages, clivus width, and clivus length) were taken into consideration. Conclusion In conclusion, with the use of CVM stages and SOS fusion stages together, an accurate and reliable age estimation can be obtained in forensic medicine.Öğe Observation of the Pulp Chamber of Maxillary First Premolars: A Micro-computed Tomographic Study(Bentham Science Publ Ltd, 2020) Serindere, Gozde; Belgin, Ceren Aktuna; Orhan, KaanBackground: There are a few studies about the evaluation of maxillary first premolars internal structure with micro-computed tomography (micro-CT). The aim of this study was to assess morphological features of the pulp chamber in maxillary first premolar teeth using micro-CT. Methods: Extracted 15 maxillary first premolar teeth were selected from the patients who were in different age groups. The distance between the pulp orifices, the diameter of the pulp and the width of the pulp chamber floor were measured on the micro-CT images with the slice thickness of 13.6 mu m. The number of root canal orifices and the presence of isthmus were evaluated. Results: The mean diameter of orifices was 0.73 mm on the buccal side while it was 0.61 mm on palatinal side. The mean distance between pulp orifices was 2.84 mm. The mean angle between pulp orifices was -21.53 degrees. The mean height of pulp orifices on the buccal side was 4.32 mm while the mean height of pulp orifices on the palatinal side was 3.56 mm. The most observed shape of root canal orifices was flattened ribbon. No isthmus was found in specimens. Conclusion: Minor anatomical structures can be evaluated in more detail with micro-CT. The observation of the pulp cavity was analyzed using micro-CT.
