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    Frequency of Erectile Dysfunction in Metabolic Syndrome Patients
    (Duzce Univ, 2014) Unal, Mustafa; Aydin, Yusuf; Ustun, Ihsan; Berker, Dilek; Erol, Kutlu; Gul, Kamile; Guler, Serdar
    Purpose: Metabolic syndrome (MS) is the most important clinical situation which predisposes the endotelial dysfunction and atherosclerosis. Nitric oxid (NO) loss is an important finding in the early stages of endothelial dysfunction. NO deficiency results erectile dysfunction (ED) signs and symptoms. We aim in this study to assess the frequency of the ED in MS patients. Method: This study includes 43 MS patients who fullfill NCEP-ATP III criteria and 29 healthy subjects. A signed permission form was taken from all of the participants. Biochemical and hormonal parameters such as fasting bood glucose (FBG), postprandial glucose (PPG), total testosterone (TT), insulin, high sensitive CRP, total cholesterol (TC), triglyceride (Tg), low density lipoprotein (LDL), high density liporotein (HDL) were measured from the blood which was taken after 12 hours fasting period. ED was evaluated by the questionnaire of International Index of Erectile Function-5 (IIEF-5) which was answered by the included subjects. Insulin resistance was calculated by HOMA-IR method by the formula of FBGxinsulin/405. Results: ED was detected in 65% of the MS group and in 13,8% of the control group. ED was divided into subgroups according to the severity. In MS patients; 18,6% had mild ED, 14% had mild-moderate ED, 14% had moderate ED and 14% had severe ED but in control group only 13,8% of them had mild ED. Although HOMA-IR value was 3,56 +/- 3,45 in MS patients with ED, it was 2,23 +/- 1,72 in patients without ED (p= 0,034). In MS patients with and without ED testosterone levels were measured as 4,5 +/- 1 and 6,1 +/- 1,56, respectively (p< 0,001). Conclusion: ED is highly prevelant in patients with MS and MS patients with ED have low testosterone levels and high HOMA-IR levels which shows insulin resistance.