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    Effect of Cutaneous Leishmaniasis Treatment on Serum Adenosine/Deoxyadenosine Deaminase Activities
    (Asian Journal Of Chemistry, 2012) Culha, Gulnaz; Berkoz, Mehmet; Yalin, Serap; Gulkan, Burcu
    Adenosine deaminase is an enzyme present in a great number of plants and animals, found from simple intervebrates to human beings. Adenosine deaminase and deoxyadenosine deaminase activities increase substantially during mitogenic and antigenic responses of lymphocytes and conversely lymphocytes blastogenesis. Various diseases characterized by the alteration of cell-mediated immunity can be effected by the serum activity of adenosine deaminase. Cutaneous leishmania is an intracellular parasite that targets and multiplies within phagocytic cells of the innate immune system such as the macrophage, dendritic cell and neutrophil. In this study, we investigated the role of treatment on adenosine deaminase and deoxyadenosine deaminase activities in the cutaneous leishmaniasis patients. For this aim, 25 treated cutaneous leishmaniasis patients, 19 untreated patients and 25 healthy control subjects were enrolled in this study. The clinical diagnosis was parasitologically confirmed Giemsa stain and by culture NNN medium. Adenosine deaminase and deoxyadenosine deaminase activities were measured spectrophotometrically by the method of Giusti. Serum adenosine deaminase and deoxyadenosine deaminase activities were higher in cutaneous leishmaniasis patients than the controls and also, adenosine deaminase and deoxyadenosine deaminase activities decreased in treated patients as compare with non-treated cutaneous leishmaniasis patients. According to these results, it is suggested that evaluation of adenosine deaminase activity in serum of patients with cutaneous leishmaniasis could be considered a useful monitoring tool for their infection status. Therefore, adenosine deaminase can be a predictive and sensitive parameter of leishmaniasis treatment.
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    Oxidative stress and antioxidant enzyme activities in patients with cutaneous leishmaniasis in endemic region of Hatay (Antioch)
    (Asian Journal Of Chemistry, 2007) Culha, Gulnaz; Yalin, Erdinc; Yalin, Serap; Eroglu, Pelin; Berkoz, Mehmet
    Leishmania is the collective name for a number of disease caused by protozoon flagellates of genus Leishmania which have diverse clinical manifestations. In this study, we investigated the effect of free radicals and antioxidants on cutaneous leishmaniasis (CL). Venous blood samples of patients and controls were collected and analyzed for serum nitric oxide (NO) and malondialdehyde, (MDA) levels, superoxide dismutase (SOD) and catalase (CAT) activities. 53 treated CL patients, 42 untreated patients,and 30 healty control subjects were enrolled in this study. The levels of MDA and NO showed a significant increase (p < 0.05) in the untreated patients when compared to the treated patients and control groups. In the untreated group, the activities of both SOD and CAT were found to be decreased (p < 0.05) compared with values in the control and treated groups. After the treatment, NO and MDA levels were decreased whereas the activities of CAT and SOD were increased. These results provide some evidence for a potential role of increased lipid peroxidation and decreased enzymatic antioxidants in cutaneous leishmaniasis. These results suggested that oxidant stress plays an important role in the pathogenesis of cutaneous leishmaniasis.
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    Öğe
    Oxidative stress and antioxidant enzyme activities in patients with cutaneous leishmaniasis in endemic region of Hatay (ANTIOCH)
    (Chemical Publishing Co., 2007) Culha, Gulnaz; Yalin, Erdinc; Yalin, Serap; Eroglu, Pelin; Berkoz, Mehmet
    Leishmania is the collective name for a number of disease caused by protozoon flagellates of genus Leishmania which have diverse clinical manifestations. In this study, we investigated the effect of free radicals and antioxidants on cutaneous leishmaniasis (CL). Venous blood samples of patients and controls were collected and analyzed for serum nitric oxide (NO) and malondialdehyde (MDA) levels, superoxide dismutase (SOD) and catalase (CAT) activities. 53 treated CL patients, 42 untreated patients and 30 healty control subjects were enrolled in this study. The levels of MDA and NO showed a significant increase (p < 0.05) in the untreated patients when compared to the treated patients and control groups. In the untreated group, the activities of both SOD and CAT were found to be decreased (p < 0.05) compared with values in the control and treated groups. After the treatment, NO and MDA levels were decreased whereas the activities of CAT and SOD were increased. These results provide some evidence for a potential role of increased lipid peroxidation and decreased enzymatic antioxidants in cutaneous leishmaniasis. These results suggested that oxidant stress plays an important role in the pathogenesis of cutaneous leishmaniasis.