Yazar "Bilgic, Yasemin" seçeneğine göre listele
Listeleniyor 1 - 5 / 5
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Assessment of Sensitivity to the Anesthesia in a Diabetic Rat Model(Wiley-Blackwell, 2015) Dokuyucu, Recep; Dogan, Hatice; Agturk, Gokhan; Cay, Emrah; Bilgic, Yasemin; Egeli, Duygu; Tutuk, Okan[Abstract Not Available]Öğe Chia seed (Salvia hispanica L.) supplementation may contribute to raising the levels of vitamin B12: An option for the vegan diet(Pontificia Universidade Catolica Campinas, 2019) Demir, Enver Ahmet; Bilgic, YaseminObjective The chia seed, an ancient pseudocereal, is rich in omega-3 fatty acids and polyphenols, and has been suggested to possess several health benefits. Although it has gained popularity among nutritionists, little is known about the systemic effects of chia and their interactions. Hence, hepatorenal indicators and plasma vitamin concentrations in chia-supplemented aluminum-exposed rats were investigated. Methods Wistar albino rats were either fed on a chia-rich- or standard-diet for 21 days and exposed to aluminum. Liver function tests (Alanine Aminotransferase, Aspartate Aminotransferase, Alkaline Phosphatase, Lactate Dehydrogenase), kidney function tests (Urea Nitrogen, Creatinine), and vitamin B-12 and folic acid measurements were performed by using an automated analyzer. Results Aluminum exposure had no influence on renal function, as did chia supplementation. However, liver function was disturbed with the exposure to Aluminum and chia was of no use against it. Surprisingly, it was found that the animals fed on a chia-rich diet displayed higher concentrations of vitamin B-12 which was not the case for folic acid. Conclusion It was deduced that a chia-rich diet has no effect on the renal function and is not able to reverse aluminum-induced hepatotoxicity; however, it may be of benefit against vitamin B-12 insufficiency and thus, it may offer a novel treatment option which is particularly important in the vegan diet.Öğe Detrimental effects of chia (Salvia hispanica L.) seeds on learning and memory in aluminum chloride-induced experimental Alzheimer's disease(Nencki Inst Experimental Biology, 2018) Bilgic, Yasemin; Demir, Enver Ahmet; Bilgic, Nilufer; Dogan, Hatice; Tutuk, Okan; Turner, CemilPolyphenols and omega-3 fatty acids are thought to have beneficial effects in Alzheimer's disease, the most common cause of dementia. Seeds of chia (Salvia hispanica L.) are highly rich in these nutrients, and thus, the present study investigated the effects of chia seeds on behavior and cognition in an aluminum-induced Alzheimer's disease model in rats. Experimental animals received chia supplementation either during the generation of the model (i.e., pretreatment) or after the model was established (i.e., treatment). A battery of behavioral and cognitive tests were performed, including open-field, elevated plus maze, Porsolt's forced swim, and Morris' water maze, to evaluate anxiety- and depression-like behaviors, and learning and memory. Results showed that chia supplementation was ineffective against Alzheimer's-related anxiety, whereas depression-like behaviors were attenuated with both pretreatment and treatment. There was no improvement in learning and memory with chia treatment. Rather, cognitive performance in chia-pretreated animals was remarkably worse as compared to their non-treated disease-induced counterparts. Hippocampal concentrations of amyloid-beta 42, amyloid precursor protein, and total tau protein were similarly increased in all disease-induced animals (despite chia supplementation), as compared to the controls. Based on these findings, chia supplementation during the progression of Alzheimer's disease may exacerbate the disease. Although the results presented here emerge from an experimental/preclinical study, we suggest cautious and careful use of chia, especially in early-stage Alzheimer's patients, until future research in different experimental settings is conducted.Öğe The Effect of Chia (Salvia hispanica L.) Seed in an Experimental Alzheimer's Disease Model(Wiley, 2018) Bilgic, Yasemin; Demir, Enver Ahmet; Bilgic, Nilufer; Dogan, Hatice; Tutuk, Okan; Tumer, Cemil[Abstract Not Available]Öğe An Undergraduate Pilot Study: The Effectiveness of Industrial Grease in a Deep Partial-Thickness Burn Model(Wiley, 2018) Gonder, Okan; Arslan, Faruk; Siyer, Ender Remzi; Bilgic, Yasemin; Demir, Enver Ahmet; Tumer, Cemil[Abstract Not Available]
