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    Öğe
    Evaluation of ivermectin tablets in the treatment of generalized canine demodicosis
    (Ecole Nationale Veterinaire Toulouse, 2007) Karakurum, M. C.; Ural, K.; Cingi, C. C.; Guzel, M.; Haydardedeoglu, A. E.; Borku, M. K.
    Sixteen privately owned dogs with generalized demodicosis included in this study. For the treatment of generalized demodicosis, tablet form of ivermectin (Efektin tablet (R) 10 mg, Sanovel) at a dose of 600 mu g kg(-1) daily was used in study dogs for 6-22 weeks. lvermectin was used at least for 2 weeks more after no mites (dead or alive) seen. All dogs had significant reduction in the in clinical signs and number of mites on skin scrapings during re-evaluations. All dogs became skin scrapings negative. After no mites were seen, treatment was continued for 2 more weeks and then stopped. But three dogs relapsed 5, 8 and 9 months after the therapy lasted. Remained 13 dogs were negative for skin scrapings and clinically normal after 12 months. Oral ivermectin, at a dosage of 600 mu g kg(-1), PO, daily, was found to be effective in resolving generalized demodicosis in 13 of 16 dogs (82,25%.) in one year follow-up after discontinuing of therapy. Although, there were some literatures evaluating the efficacy of the use of injectable formula of ivermectin, to the present authors' knowledge these is the first report evaluating tablet form of ivermectin in the treatment of canine demodicosis.
  • Küçük Resim
    Öğe
    Nimesulide-induced acute biliary tract injury and renal failure in a kitten: a case report
    (Czech Academy Agricultural Sciences, 2008) Borku, M. K.; Guzel, M.; Karakurum, M. C.; Ural, K.; Aktas, S.
    A 3-month-old male kitten was presented to our clinic with malaise, vomiting and jaundice. In the anamnesis, we learned that the cat had a history of anorexia, sneezing, and nasal discharge and that the owner had administered 100 mg/day (t.i.d.) nimesulide orally for three days. In the laboratory study, high levels of serum alkaline phosphatase, gamma-glutamyl transtransferase, total bilirubin, direct bilirubin, indirect bilirubin, urea, and creatinine were detected. All the clinical signs and laboratory abnormalities returned to normal levels after cessation of the nimesulide and supportive treatment. In this case, clinical and laboratory findings were thought to be compatible with nimesulide-induced acute biliary injury and renal failure. This case report indicates that the household pets are at risk of toxic drugs administered by their owners and great caution should be taken in administering NSAIDs in cats.