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    The effects of two different exercise programmes on adipose tissue hormones in sedentary middle-aged women
    (Taylor & Francis Ltd, 2015) Ozcan, Oguzhan; Bostanci, M. Omer; Cicek, Guner; Yamaner, Faruk
    Adipokines play an important role in obesity and related inflammatory disorders. We aimed to determine the effects of exercise training on serum adipokines. Forty sedentary women were randomly assigned to two groups as aerobic (AE) and core exercise (CE). The exercise programmes were performed 4 days a week for 16 weeks. Blood samples were taken before and after the 8 and 16 weeks training period. Percent changes of each parameter were calculated. Sixteen weeks of exercise caused significant decrease in body weight and fat mass (p<0.001), significant increase in adiponectin (16.1% in AE, 15.8% in CE group, p<0.05) and resistin levels (21.1% in AE and 26.6% in CE group, p<0.05) but had no effect on leptin and ghrelin levels. Eight weeks of exercise had no effect on adipokines except leptin. These data suggest that both exercise programmes have improving effects on body composition, adiponectin and resistin levels.
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    Hyperemesis gravidarum affects maternal sanity, thyroid hormones and fetal health: a prospective case control study
    (Springer Heidelberg, 2015) Duman, Nuriye Buyukkayaci; Ozcan, Oguzhan; Bostanci, M. Omer
    Hyperemesis gravidarum (HG) is a condition of severe nausea or vomiting accompanied by various complications during pregnancy. In the present study, we aimed to demonstrate the effects of HG on mother and fetus health. Control and case group were arranged from 50 healthy pregnant women and 50 pregnant women with HG. Information about the participant women was gathered with data collection form and Beck's Depression Inventory (BDI) and State Anxiety Inventory (SAI) were administered to the women. Following an abortion or delivery, the data about birth complications and neonatal health were collected. All laboratory results (blood count, thyroid hormones, electrolyte values and biochemical parameters) were gathered from the laboratory information system used in the hospital. It was found that in the case group, mean postpartum weight, serum hemoglobin, hematocrit and thyroid stimulant hormone levels were lower than control group (p < 0.01). Conversely, case group women have higher T3 and T4 levels than control group (p < 0.01). There was no significant difference between the two groups in terms of intrauterine growth retardation, low birth weight and abortion but it was observed that women with HG had often delivered prematurely. The mean scores of BDI and SAI in the case group were higher than those of control group. These results suggested that HG may have adverse effects on both mother and baby's health. Pregnant women with HG should be provided with training and consultancy services and be closely monitored in terms of anemia and thyroid hormones.
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    Inhibition of neuronal nitric oxide synthase prevents iron-induced cerebellar Purkinje cell loss in the rat
    (Nencki Inst Experimental Biology, 2008) Gulturk, Sefa; Kozan, Ramazan; Bostanci, M. Omer; Sefil, Fatih; Bagirici, Faruk
    Iron plays an important role in maintaining normal. brain function. However, in many neurodegenerative diseases abnormal iron accumulation in specific brain regions has been consistently reported. In this study, we investigated the neurotoxic effect of the intracerebroventricularly injected iron on the cerebellar Purkinje cells in the rat and the role of nitric oxide (NO) in this process. The role of NO in rats administered iron (FeCl(3)6H(2)O) was examined with the use of a donor of NO, L-arginine (L-Arg), and a central selective inhibitor of NO synthase, 7-nitroindazole (7-NI). For this reason, rats were divided into 5 groups: control, iron-injected, iron plus L-Arg, iron plus 7-NI, and iron plus L-Arg plus 7-NI. Means (value standard deviation) of the total numbers of Purkinje cells in the cerebellum were estimated as 337 +/- 23, 209 +/- 16, 167 +/- 19, 305 26, and 265 +/- 14 thousands in the control, iron, iron plus L-Arg, iron plus 7-NI, and iron plus L-Arg plus 7-NI groups, respectively. Iron treatment alone and the combination of iron and L-Arg caused a significant reduction in the total number of cerebellar Purkinje cells. Therefore, L-Arg increased the Purkinje cell loss induced by treatment with iron. These data show that inhibition of the neuronal NOS by 7-NI can prevent some of the deleterious effects of iron on cerebellar Purkinje cells. Presence of L-arginine decreased the neuroprotective effect of 7-NI.