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    PROTECTIVE EFFECT OF LYCOPENE ON OXIDATIVE STRESS INDUCED BY DIFFERENT DOSES OF 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN IN BRAIN, LIVER, KIDNEY, AND HEART TISSUE OF RATS
    (Soc Stiinte Farmaceutice Romania, 2011) Sakin, Fatih; Bulmus, Funda Gulcu; Servi, Kadir; Popa, Lacramioara
    The aim of this study was to investigate the possible protective role of lycopene (LYC) on liver, kidney, heart, and brain in male rats exposed to different doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Forty-eight rats were divided into six groups. The first group received 0.5 mL corn oil as control; the second group was treated with 10 mg/kg bw/day LYC. Groups 3 and 4 were treated to 50 and 500 ng/kg bw/day of TCDD, respectively. Groups 5 and 6 were subjected to 50 and 500 ng/kg bw/day of TCDD along with 10 mg/kg bw/day of LYC, simultaneously. The duration of the experiment was 13 weeks. While the exposure to TCDD increased the levels of malondialdehyde (MDA), it decreased glutathione (GSH) levels, and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities. However, LYC-treatment decreased the high MDA levels and increased GSH, SOD, GSH-Px, and CAT activities. In conclusion, LYC treatment decreased TCDD-induced lipid peroxidation and supported the antioxidant activity. It is suggested that LYC has a protective effect against oxidative stress induced by TCDD.
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    Protective Effects of Alpha-Lipoic Acid on Oleic Acid-Induced Acute Lung Injury in Rats
    (Galenos Publ House, 2013) Bulmus, Funda Gulcu; Gursu, Mehmet Ferit; Muz, Mehmet Hamdi; Yaman, Ihsan; Bulmus, Ozgur; Sakin, Fatih
    Background: Oxidative stress is believed to be an important factor in the pathogenesis of acute lung injury (ALI). Aims: The aim of this study was to investigate the possible protective role of alpha-lipoic acid (alpha-LA) on oleic acid (OA)-induced ALI in rats. Study Design: Animal experiment. Methods: A total of thirty-five rats were divided into five groups in the study. Group 1 served as a control group. Rats in Group 2 (alpha-LA) were administered alpha-LA intraperitoneally at a dose of 100 mg/kg body weight (SW). Rats in Group 3 (OA) were administered OA intravenously at a dose of 100 mg/kg BW. In Group 4 (pre-OA-alpha-LA), alpha-LA was given 15 minutes prior to OA infusion, and in Group 5 (post-OA-alpha-LA), alpha-LA was given two hours after OA infusion. Four hours after the OA infusion, rats were decapitated. Blood samples were collected to measure serum levels of malondialdehyde (MDA) and glutathione (GSH), and the levels of activity for superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). Lung tissue samples were taken for histopathological examination. Results: Exposure to OA resulted in increases in serum MDA levels (p<0.001), as well as histopathological lesions in lung tissue, and decreases in CAT (p<0.05), GSH-Px (p<0.05) activities and GSH (p<0.05) levels. On the other hand, MDA levels were decreased significantly (p<0.001), while CAT (p<0.05), GSH-Px (p<0.01) activities and GSH (p<0.05) levels were increased significantly in the pre-OA-alpha-LA group compared with the OA group. Conclusion: alpha-LA was found to lessen oxidative stress and to have positive effects on antioxidants in cases of OA-induced ALI. In conclusion, alpha-LA appears to have protective effects against ALI and potential for the prevention of ALI.
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    Protective effects of curcumin on antioxidant status, body weight gain, and reproductive parameters in male rats exposed to subchronic 2,3,7,8-tetrachlorodibenzo-p-dioxin
    (Taylor & Francis Ltd, 2013) Bulmus, Funda Gulcu; Sakin, Fatih; Turk, Gaffari; Sonmez, Mustafa; Servi, Kadir
    The aim of this study was to investigate the effects of curcumin (CUR) on antioxidant status, body weight (BW) gains, and some reproductive parameters in male rats exposed to subchronic doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Thirty-two rats were divided into four groups. The first group was kept as control. The second group (TCDD group) was given TCDD at a dose of 50ngkg(-1) BW per day; the third group (CUR group) was treated with CUR at a dose of 80mgkg(-1) BW per day. The fourth group (TCDD + CUR group) was given TCDD and CUR at the same doses simultaneously. Malondialdehyde (MDA) levels were significantly increased in the TCDD group. In addition, TCDD exposure decreased liver superoxide dismutase (SOD) activity, catalase (CAT) activities of kidney and brain, glutathione peroxidase (GSH-Px) activities of liver, kidney, and brain, and glutathione levels of liver, kidney, and heart. However, CUR treatment with TCDD exposure decreased MDA levels in all tissues and increased SOD activities of liver, kidney, and brain, CAT activity of heart, and GSH-Px activities of heart and brain. TCDD caused a decrease in BW gain, and CUR partially eliminated this effect of TCDD. In addition, while reproductive organ weights, sperm concentration, and sperm motility tended to decrease with TCDD exposure, these effects tended to be close to normal levels by CUR treatment. In conclusion, CUR was seen to be effective in the treatment and prevention of toxicity induced by subchronic TCDD exposure.