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Öğe Aberrant Internal Carotid Artery in the Tympanic Cavity(Lippincott Williams & Wilkins, 2016) Yanmaz, Rasim; Okuyucu, Semsettin; Burakgazi, Gulen; Bayarogullari, HanifiObjectives:Presence of aberrant internal carotid artery (ICA) in the tympanic cavity is a very rare case and therefore the diagnosis is a challenge. Here, the authors aimed to address the importance of the diagnosis since the intervention to the middle ear and implants is increasing in number and this condition may lead to life-threatening bleeding.Methods:Between 2012 and 2016, among the patients referred to the authors' Radiology Department from the Department of Otolaringology for the evaluation of the temporal region for various indications, the authors reported this anomaly in 6 patients and multidetector computerized tomography of these 6 patients and magnetic resonance imaging of 2 were assessed in detail.Results:The mean age of the 6 patients was 28.8 and aberrant ICA abnormality was observed in 2 patients bilaterally and 4 patients unilaterally on the right side. In 1 patient ICA was not totally regressed and observed as hypoplastic. In one of the patients, dehiscence was evident between ICA and the cochlea. Moreover, in 1 patient the contralateral ICA was not observed.Conclusion:Although rare, aberrant ICA is an abnormality that should be kept in mind by the clinicians and the radiologists, since it leads to abundant bleeding when undiagnosed before the surgical interventions.Öğe Antronasal Polyp Extending to Orbital Fossa(Lippincott Williams & Wilkins, 2017) Bayarogullari, Hanifi; Burakgazi, Gulen; Okuyucu, SemsettinSinonasal infections and nasal polyps can be taken as 2 components of a disease. Polyps due to chronic inflammations of nasal cavity and sinuses are not rare. They may present with various clinical signs and symptoms, while the secondary complications may cause serious problems. They are most commonly treated medically, although surgery is the therapy of choice in some conditions. The complications can be listed as mucocele formation, orbital inflammation, intracranial extension by erosion of the boney structures.Öğe Comparative study of the volume of the temporal lobe sections and neuropeptide effect in Alzheimer's patients and healthy persons(Taylor & Francis Ltd, 2021) Petekkaya, Emine; Burakgazi, Gulen; Kus, Berna; Melek, Ismet Murat; Arpaci, AbdullahAim The aim of this study was to make a volumetric comparison of some medial temporal lobe structures and neuropeptides between the patients of Alzheimer's disease (AD) and healthy individuals. Method The study comprised of a group of patients diagnosed with mild AD (n:15) and a Control group (n:15) (16 females, 14 males, mean age:72.90 +/- 4.50). Voxel-based morphometry and MRICloud analyses were performed on the MR images taken in 3D measurements of gray matter volumes of all subjects. Following a 10-minute hug test, blood samples were taken from all participants for oxytocin (OT) and arginine vasopressin (AVP) analyses. Results The patient group had a statistically lower right hippocampus volume (p = 0.004) and OT values (p = 0.028) than the Control group. OT signal values increased with a volume increase in the right parahippocampal gyrus (PHG_R), and OT conc. and AVP conc. values increased with increasing volume of the PHG_R. Conclusion It is suggested that the right hippocampus, right fusiform gyrus, left amygdala, left parahippocampal gyrus, and left entorhinal cortex atrophies can be used as predictors in the early diagnosis of AD. The positive correlation between PHG_R and neuropeptides showed the need to investigate the PHG and OT function more deeply.Öğe Diagnostic accuracy of angiopoietin-like protein 2 and atherosclerotic variables in psoriasis vulgaris using ROC analysis(Bayrakol Medical Publisher, 2021) Celik, Ebru; Celik, Yusuf; Burakgazi, Gulen; Cakirca, Gokhan; Ucgul, GokhanAim: Psoriasis vulgaris is a chronic inflammatory skin disease associated with various comorbidities such as metabolic syndrome and cardiovascular disease. The disease is affected by many variables. Angiopoietin-like protein 2 (ANGPTL2) is a proinflammatory cytokine, and increased serum levels are associated with inflammation, obesity, dyslipidemia, metabolic syndrome, and atherosclerosis. The aim of this study was to determine the diagnostic accuracy of the new variable ANGPTL2 and other atherosclerotic variables for psoriasis, using Receiver Operating Characteristic (ROC) analysis. Material and Methods: The study included 41 psoriasis patients and 43 healthy volunteers. Ultrasound examination of the carotids and carotid intima-media thickness (CIMT) measurements were performed in all participants. Serum ANGPTL2 levels, lipid levels/ratios and anthropometric measurements were recorded. A ROC curve of multivariate statistical methods was used for statistical evaluation. Results: According to the results of the ROC curves, seven diagnostic variables (ANGPTL2, BMI, weight, systolic blood pressure, waist circumference for females, uric acid and LDL-cholesterol) were found to be significant. The highest Area Under the Curve (AUC) value was found for ANGPTL2; AUC=0.721, 95% CI: 0.595-0.847, p=0.002. There was no significant difference in the lipid ratios and CIMT measurements between psoriasis patients and healthy controls. Discussion: This study revealed that increased ANGPTL2 levels in psoriasis patients are evidence of the strong relationship between the disease and atherosclerosis. Therefore, the measurement of serum ANGPTL2 level may be a new marker that can be used to determine the risk of early atherosclerosis and metabolic complications in psoriasis patients.Öğe Effect of Sickle Cell Anemia on Pelvic Dimensions: A Magnetic(Kowsar Publ, 2017) Atci, Nesrin; Gozukara, Ilay; Ozturk, Fatma; Burakgazi, Gulen; Kurt, Raziye Keskin; Karazincir, SinemBackground: The cesarean delivery rate tends to be higher in women with sickle cell anemia (SCA) and sickle cell trait (SCT) for various reasons. However, pelvic contracture, which may lead to cesarean sections, has never before been studied in these groups. Objectives: The aim of this study was to investigate magnetic resonance (MR) pelvimetry findings of women with SCA and SCT. Patients and Methods: We studied 66 women who underwent MR pelvimetry between March and June 2015 at our center. Our prospective study included 21 women with SCA, 20 women with SCT, and 25 control women. Sagittal inlet, sagittal mid-pelvis, transverse inlet, transverse mid-pelvis and transverse outlet diameters were measured on MR images. The mean diameters were compared with each other and with the control group Results: Sagittal inlet and transverse inlet were not significantly different between the groups. Also, mid-pelvic diameters for the sagittal and transvers mid-pelvis were similar between the groups. Even though the transverse outlet seems to be lesser in the SCA group compared with other groups, it was not statistically significant. Conclusion: Our study demonstrated that the pelvic roofs of women with SCA and SCT are indistinguishable from healthy women. Thereby, maternal pelvic structures that impact delivery types may not be significantly changed in SCA and SCT diseases. We believe that when making decisions about modes of delivery, these results should be taken into consideration.Öğe Evaluation of dural venous sinuses and confluence of sinuses via MRI venography: anatomy, anatomic variations, and the classification of variations(Springer, 2018) Bayarogullari, Hanifi; Burakgazi, Gulen; Duman, TaskinWe aimed to determine the anatomical variations more comprehensively particularly at the level of superior sagittal sinus (SSS), confluence of sinuses (CS), transverse sinuses (TS), straight sinuses (SS) and occipital sinuses (OS) with the help of the images obtained via MRI venography, and to contribute to the classification efforts. In our retrospective study, we evaluated 211 patients who admitted to our hospital with various complaints and cerebral MRI venography has been performed. All investigations were performed by using 1.5-T MRIscanner (Achiva, Philips) with a VEN-3D -PCA MR venous angiography technique. Section thickness was 0.8 mm and axial plane was used. Other parameters were as follows: 17/7.1 (TR/TE), flip angle, 10.00, FOV, 220-mm, and matrix 244x140. We divided our cases into 3 types but we increased the number of subgroups. Type I was divided into 4 subgroups (Type IA, IB, IC, ID), Type II into 9 (Type IIA1, IIA2, IIB1, IIB2, IIC, IID1, IID2, IIE1, IIE2) and Type III into 2 (Type IIIA, IIIB). Type I constitutes a 26.06% of whole cases, and Type II 59.71%, Type III 14.21%. In our cases R-TS wasn't revealed in 10 cases (4.73%) whereas in 37 cases (17.53%) it was hypoplastic. L-TSwasn't shown in 26 cases (12.32%) and in 85 cases (49.09%) it was hypoplastic. R-Sig S wasn't revealed in 7 (3,31%) and was hypoplastic in 34 (16.11%) whereas L-Sig S wasn't present in 2 (0.94%) and hypoplastic in 72 (34.12%). Among these cases 14 had bilateral hypoplastic TS (6.63%). In cases with hypoplastic TS or Sig S, as an alternative pathway 30 patients had OS (14.21%). Two of these patients had double OS. Our wish is to contribute to the efforts of clarifying and classifying the intracranial venous structures and their anatomical variations. We hope our study enlightens a path in this field for future studies.Öğe Evaluation of Radiological Images of Cases Operated for Nasal Polyp(Aves, 2022) Burakgazi, Gulen; Arli, CengizObjective: In this study, we aimed to evaluate the differential diagnosis of nasal polyps and infected nasal polyps before the operation with density measurement in paranasal sinus computed tomography examination. Methods: The study included 129 patients (93 men and 36 women; mean age 41.00 years; range 13 to 82 years) diagnosed as nasal polyps (nasal polyps group) and 26 patients (17 men, 9 women; mean age 42.50 years; range 16 to 74 years) diagnosed as infected nasal polyps. In the preoperative paranasal computed tomography examination, the nasal polyps density of the patients was scored according to the Lund-Mackey system. To measure the volume of inflammatory opacification, the soft tissue density ratio (%) was measured. Neutrophil to lymphocyte ratio, mean platelet volume values, Lund-Mackey system, and soft tissue density ratio scores were statistically compared in all the groups. Results: The median mean platelet volume value was 9.40 (6.4-12.0) in the nasal polyps group and 10.20 (7.9-12.1) in the infected nasal polyps group with a statistically significant difference (P = .007). There was a significant positive correlation between infected nasal polyps and mean platelet volume (P = .006, r = 0.219**), Lund-Mackey system total, and soft tissue density ratio total (P = .000, r = 0.797**). According to the results of receiver operating curve analysis in patients with infected nasal polyps, sensitivity 61.5% and specificity 60.5% for mean platelet volume (P = .007, area under curve: 0.669 [0.574-0.763]) were found. The cut-off point for mean platelet volume value was > 9.95. Conclusion: If there is an infection in patients with nasal polyps, surgery should be considered after antibiotic therapy. The use of mean platelet volume as a marker of inflammation in these patients appears to be more reliable than the Lund-Mackey system and soft tissue density ratio scores.Öğe Radiological Imaging of Rare Intracranial Complications Secondary to Otitis Media and Mastoiditis(Lippincott Williams & Wilkins, 2017) Burakgazi, Gulen; Bayarogullari, Hanifi; Ozturk, Fatma; Arli, Cengiz; Motor, Vicdan Koksaldi; Yanmaz, Rasim; Atci, NesrinAcute otitis media used to cause fatal results because of its intracranial complications before the introduction of potent and effective antibiotics. After the introduction of antibiotics, complications have started to be observed more frequently as a result of chronic otitis media and especially in children. Because clinical findings changed and became indistinct, the diagnosis of otitis and mastoiditis has been made occasionally with imaging findings only after complications occurred. Multidetector computed tomography and magnetic resonance imaging are efficient and sufficient methods in the rapid diagnosis and should be immediately referred methods.Öğe Two cases with giant pseudo-aneurysm of vertebral artery secondary to shrapnel injury(Springer, 2016) Bayarogullari, Hanifi; Yanmaz, Rasim; Kartal, Ismail; Burakgazi, GulenDue to their locations, vertebral arteries (VA) are structures that are rarely injured after traumas. Formation of vertebral pseudo-aneurysm (PA) because of pieces of shrapnel is also rare. It causes clinical findings like cervical mass after the injury Two Syrian 12- and 17-year-old male patients were admitted to the Department of Ear, Nose and Throat with the complaint of swelling in the left lower cervical region. In their USG examination which was ordered to investigate the cervical lesion, a lesion consistent with PA which shows a prominently thick wall structure due to circumferential thrombus formation and fibrotic tissue, chaotic flow, and ying-yang appearance in the centrally located cavity of the lesion in a color Doppler examination was detected. Later, multi-detector computed tomography angiography (MDCTA) was planned to demonstrate pseudo-aneurysms (PAs). Because there was no report on the development of giant pseudo-aneurysms secondary to shrapnel injury to date and because we thought these cases are demonstrative, we found the cases suitable for presenting as case reports.Öğe Ultrasonographic shear wave elastography of the thyroid in patients with sickle cell anemia(Walter De Gruyter Gmbh, 2022) Burakgazi, Gulen; Ilhan, Gul; Ozcan, Oguzhan; Dirican, EmreBackground Although thyroid radiology has been conducted in patients with sickle cell anemia (SCA), to our knowledge, there is no report of thyroid gland assessment using ultrasonographic shear wave elastography (US-SWE). Objectives To determine values for ultrasonographic US-SWE of the thyroid in patients with SCA and correlations between thyroid elasticity and biochemical variables used to evaluate thyroid function. Methods Prospective case-control observational study of 36 patients with SCA and 33 healthy volunteer controls. US-SWE measurements of thyroid gland parenchyma and biochemical parameters of the participants were obtained and compared, and the diagnostic accuracy of elasticity was determined. Results The thyroid volume was smaller in patients with SCA than that in controls (P = 0.001). Compared with the controls, the patients with SCA had significantly lower serum levels of free triiodothyronine (fT3) (P = 0.004) and thyroglobulin (Tg) (P = 0.001) and significantly higher levels of thyroid-stimulating hormone (P = 0.028). Thyroid stiffness was significantly higher in the left lobe (LL) of the patients with SCA than in the controls (P = 0.003). In the patients with SCA, we found a significant correlation between right lobe (RL) and LL stiffness and serum levels of Tg (RL [r = -0.439] and LL [r = -0.484]; P = 0.021) and fT3 (RL [r = -0.463] and LL [r = -0.386]; P = 0.012). Receiver operating characteristic (ROC) curve analysis of thyroid elasticity that represented a diagnosis of SCA found a cutoff of >7.31 kPa, a sensitivity of 52.0%, and a specificity of 72.0% for the RL (P = 0.316, area under the curve [AUC] 0.570), and a cutoff of >8.06 kPa, a sensitivity of 58.0%, and a specificity of 84.0% for the LL (P = 0.011, AUC 0.680). Conclusions US-SWE can be used to follow up thyroid changes in patients with SCA.
