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    Öğe
    Investigation of thiol/disulfide homeostasis in familial mediterranean fever patients
    (Derman Medical Publ, 2018) Cakirca, Gokhan; Celik, Muhammet Murat; Erdal, Huseyin; Neselioglu, Salim; Erel, Ozcan; Basarali, Mustafa Kemal; Cakirca, Tuba Damar
    Aim: To determine the thiol/disulfide homeostasis in patients with familial Mediterranean fever (FMF) and its correlation with the levels of inflammatory markers consisting of white blood cell count, erythrocyte sedimentation rate, C-reactive protein and fibrinogen. Material and Method: This study was performed in the internal Medicine department of Mustafa Kemal University Hospital in Turkey. A total of 27 FMF patients in the attack period (AP), 33 FMF patients in the attack-free period (AFP), and 36 healthy controls participated in this study. Thiol/disulfide profile parameters were detected using the novel method of Erel and Neselioglu. Results: Total and native thiol levels of the FMF-AP group were markedly lower than those of healthy controls, while the difference in disulfide level was not statistically significant. Thiol/disulfide levels in the FMF-AFP group were similar to the levels in both the FMF-AP group and healthy controls. Correlation analysis showed a negative correlation between fibrinogen levels and total and native thiol levels, while there was a positive correlation between white blood cell count and disulfide levels in the FMF-AP group. Discussion: The findings suggest that decreased concentrations of total and native thiol in patients with FMF-AP are likely to be an outcome of inflammation-induced oxidative stress.
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    Öğe
    Relationship between COVID-19 infection and ABO and Rh blood group systems
    (Cukurova Univ, Fac Medicine, 2022) Cakirca, Tuba Damar; Bal, Tayibe
    Purpose: The aim of this study was to determine whether there is a relationship between COVID-19 infection and ABO and Rh blood groups.Materials and Methods: 1360 patients with positive SARS-CoV-2 RNA test between April 2020 and March 2022 and 80219 healthy controls whose blood groups were determined before March 2020 were included in this study. Patients were classified according to disease severity as mild, moderate, severe and critical.Results: Patient and control groups were matched in terms of age and gender using case-control matched method. 1360 patients and 1161 controls were included in the analysis. Of the patients, 42.1% (n=572) had mild, 41.5% (n=564) moderate, 13.8% (n=187) severe and 2.7% (n=37) critical course of infection. It was observed that patients with blood group A were 1.33 times more at risk (OR: 1.33, 95%Cl: 1.12-1.56) for the development of COVID-19 infection compared to patients with other blood groups. No relationship was found between ABO and Rh blood groups and severe-critical COVID-19 disease, need for intensive care and mortality. However, when patients are divided into two groups as mild and non-mild (moderate, severe, critical); the frequency of having O and B blood groups was found to be significantly higher in non-mild cases than in mild cases ( (53.3% and 46.7%), (64.5% and 35.5%, respectively). Conclusion: In our study, while A blood group was found to be at risk for the development of COVID-19 infection, no relationship was found between Rh blood groups and susceptibility to the disease. In addition, the rate of O and B blood groups was found to be higher in patients who did not have mild disease.