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    Body weight and white coat hypertension
    (2009) Helvaci, Mehmet Rami; Kaya, Hasan; Sevinc, Alper; Camci, Celaletdin
    Objective: To understand prognostic significance of white coat hypertension (WCH), and any its association with excess weight. Methodology: We studied consecutive check up patients between the ages of 35 and 70 years to be able to see possible consequences of excess weight on health and to avoid debility induced weight loss in elderly people. Results: The study included 721 cases (426 females). Prevalences of normal weight, overweight, and obesity were detected as 19.0%, 43.3%, and 37.5%, respectively. There were gradual and significant increases in the prevalences of WCH and hypertension (HT) towards the overweight and obesity groups (p<0.001 for all). So 73.7% of the obesity cases had either WCH or HT, and overall prevalence of WCH was 37.9%, which was nearly equal to the prevalence of obesity. When we compared the groups according to the prevalences of hyperbetalipoproteinemia, dyslipidemia, diabetes mellitus (DM), and coronary heart disease (CHD), gradual and significant increases towards the overweight and obesity groups were seen nearly in all steps. Conclusion: There is gradual increased prevalence of WCH in the overweight and obesity groups, parallel to gradually increased prevalences of hyperbetalipoproteinemia, dyslipidemia, HT, DM, and CHD. In addition nearly equal prevalence of WCH with obesity, and additional very low prevalence of sustained normotension in obesity group, WCH should be accepted as an alarming sign of excess weight and many associated disorders in future rather than just being a predisposing factor of HT and atherosclerosis alone. Its management should be focused on prevention of excess weight.
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    BODY WEIGHT AND WHITE COAT HYPERTENSION
    (Professional Medical Publications, 2009) Helvaci, Mehmet Rami; Kaya, Hasan; Sevinc, Alper; Camci, Celaletdin
    Objective: To understand prognostic significance of white coat hypertension (WCH), and any its association with excess weight. Methodology: We studied consecutive check up patients between the ages of 35 and 70 years to be able to see possible consequences of excess weight on health and to avoid debility induced weight loss in elderly people. Results: The study included 721 cases ( 426 females). Prevalences of normal weight, overweight, and obesity were detected as 19.0%, 43.3%, and 37.5%, respectively. There were gradual and significant increases in the prevalences of WCH and hypertension ( HT) towards the overweight and obesity groups (p<0.001 for all). So 73.7% of the obesity cases had either WCH or HT, and overall prevalence of WCH was 37.9%, which was nearly equal to the prevalence of obesity. When we compared the groups according to the prevalences of hyperbetalipoproteinemia, dyslipidemia, diabetes mellitus (DM), and coronary heart disease (CHD), gradual and significant increases towards the overweight and obesity groups were seen nearly in all steps. Conclusion: There is gradual increased prevalence of WCH in the overweight and obesity groups, parallel to gradually increased prevalences of hyperbetalipoproteinemia, dyslipidemia, HT, DM, and CHD. In addition nearly equal prevalence of WCH with obesity, and additional very low prevalence of sustained normotension in obesity group, WCH should be accepted as an alarming sign of excess weight and many associated disorders in future rather than just being a predisposing factor of HT and atherosclerosis alone. Its management should be focused on prevention of excess weight.
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    Öğe
    Platelet and white blood cells in severity of sickle cell diseases
    (Prensa Medica Argentina, 2014) Helvaci, Mehmet Rami; Aydogan, Fusun; Sevinc, Alper; Camci, Celaletdin; Dilek, Imdat
    Background: We tried to understand whether or not there is an association between platelet (PLT) and white blood cell (WBC) counts of peripheric blood and severity of sickle cell diseases (SCDs). Methods: The SCDs patients with red blood cell transfusions of less than 50 units in their lives were put into the first and 50 units or higher were put into the second groups. Results: The study included 316 cases. There were 224 cases (70.8%) in the first and 92 cases (29.1%) in the second groups (p<0.001). Male ratio was significantly higher in the second group (45.5% versus 64.1%, respectively, p<0.001). Although both the WBC and PLT counts were higher in the second group, the difference was only significant for the PLT counts (p= 0.005) probably due to the small sample sizes. Although prevalences of smoking, avascular necrosis of bones, cirrhosis, and exitus were similar in the groups, mean number of painful crises per year, digital clubbing, chronic obstructive pulmonary disease, leg ulcers, stroke, chronic renal disease, and coronary heart disease were significantly higher in the second group (p<0.05 for all). Conclusion: Although the difference was statistically nonsignificant between the WBC count and severity of SCDs probably due to the small sample sizes of the study, there was a highly significant association between the PLT count and disease severity. So the higher PLT and WBC counts of the second group may indicate the significant roles of the cells for the chronic endothelial damage of the SCDs all over the body.
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    Smoking and sickle cell diseases
    (Cardiology Academic Press, 2014) Helvaci, Mehmet Rami; Sevinc, Alper; Camci, Celaletdin; Keskin, Ali
    Background: We tried to understand whether or not there is an association between higher prevalence of smoking and autosplenectomy in sickle cell diseases (SCDs) cases. Methods: All SCDs patients with and without autosplenectomy were studied, and they were compared in between. Results: The study included 253 patients (124 females). There were 168 cases (66.4%) with autosplenectomy and 85 cases (33.5%) without (p<0.001). Autosplenectomy cases were significantly elder than the others (30.7 versus 25.7 years, p= 0.000). Female ratios were similar in both groups (p>0.05). Thalassemia minors were significantly higher in cases without autosplenectomy (91.7% versus 50.0%, p<0.001). Interestingly, prevalence of smoking was significantly higher in cases with autosplenectomy (16.6% versus 9.4%, p<0.05). The mean units of transfused red blood cells (RBCs) and painful crises per year were similar in both groups (p>0.05 for both). Both the white blood cell and platelet counts of the peripheric blood were higher in cases with autosplenectomy, significantly (p = 0.000 for both), whereas the mean hematocrit value was significantly lower in them (p= 0.000). On the other hand, prevalences of digital clubbing, pulmonary hypertension, leg ulcers, chronic renal disease, coronary heart disease, and rheumatic heart disease were significantly higher in cases with autosplenectomy (p<0.05 for all). Conclusion: Due to the strong atherosclerotic background of smoking and SCDs, there may be an association between higher prevalence of smoking and clinical severity of the SCDs, and the spleen, as a filter of blood for the abnormally hard RBCs, may strongly be affected in smoker patients with SCDs.