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    The Effect of Coenzyme Q10 (Ubiquinone) on Random Pattern Skin Flap Survival in Rat Model
    (Lippincott Williams & Wilkins, 2016) Can, Asli; Temel, Metin; Dokuyucu, Recep; Mutaf, Mehmet
    Background: In this study, the effect of coenzyme Q(10) (CQ(10)) on flap survival was investigated. Methods: FiftyWistar Albino rats were divided into 5 groups. The survival rates of the skin flaps were assessed 10 days after complete elevation of the flaps. Regions of survival and necrosis were drawn on transparent acetate sheets and scanned into a computer. Tissue samples were assessed histopathologically after staining with hematoxylin-eosin, vascular endothelial growth factor staining and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-Biotin Nick End-labeling staining. To evaluate the antioxidant effect of CQ(10); malondialdehyde, nitric oxide levels were measured. Results: Viable flaps area was found higher in groups 3 and 4 as compared to groups 1, 2, and 5. In terms of vascular proliferation, elevated angiogenesis was observed in pathological specimens of groups 3 and 4 as compared to groups 1, 2, and 5. Malondialdehyde levels in groups 3 and 4 were found to be significantly decreased as compared to groups 1, 2 and 5 (P < 0.05). Moreover, serum levels of CQ(10) were found significantly increased in groups 3 and 4 (P < 0.05). Conclusions: In conclusion, CQ(10) significantly improves flap viability in rat model, and the highest levels of serumCQ(10) can be obtained by oral administration.