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    Analysis of the histopathological changes of epidural space and endoneural structure in lumbar spinal canal stenosis : A model for chronic compression of the rat cauda equina
    (2011) Özdemir, Nail; Acar, Ümit Dursun; Canda, M. Şerefettin
    Objective: The purpose of study was to produce chronic cauda equina compression in rats for analysis of the histopathologic changes of two different group. Method: Twenty-one adult male Wistar rats were studied. A single-lumen polyurethane catheter was used. Seven rats, the sham-operated group, had laminectomy only. The spinal canal was obstructed 25% in seven rats, 65% in another seven. Obstruction area of the group that was obstructed 25% and 65%, proximal and distal region of this area and laminectomy area of the sham-operated group of which only laminectomy was applied were examined even in epidural space and endoneural structures histopathologically. In consideration of information that were obtained from examinations; hemorrhage, inflammation, fibroblast proliferation, capillary proliferation in epidural space; nerve fiber damage, edema, inflammation and hemorrhage parameters in endoneural structures were evaluated by mild, moderate and severe categories. Results: No nerve fiber damage was present in laminectomy area and its proximal and distal of the sham-operated group. All samples from the obstruction area in the 25% and 65% obstructed groups showed nerve fiber damage. Nerve fiber damage was observed both proximal and distal area of all sections in 65% obstructed group. Conclusions: Neurological deficit was observed only in 65% group. Impression degree seems to be important in formation of neurological parameter. Changes in nerve fiber structure are observed in slight obstructions. These changes characterized with vacuolization are observed more frequent when the obstruction increases. Also, distal and proximal area of this impression area is effected in severe lumbar stenosis.
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    Hatay ilinde kistik ekinokokkozis sorunu
    (2008) Hakverdi, Sibel; Çulha, Gülnaz; Canda, M. Şerefettin; Yaldız, Mehmet; Altıntaş, Süleyman
    Ekinokokkozis, Echinococcus granulosus ve E. multilocularis tarafından oluşturulan zoonotik bir enfeksiyondur. Ülkemiz dahil olmak üzere birçok ülkede ciddi bir halk sağlığı problemi olarak karşımıza çıkmaktadır. Hatay İl'inde daha önce Ekinokokkozis ile ilgili bir çalışma yapılmadığı için, ilimizdeki oranları belirlemek ve konuya dikkat çekmek amacıyla Mustafa Kemal Üniversitesi Tıp Fakültesi Araştırma hastanesi ile Antakya ve İskenderun Devlet Hastanelerinin patoloji laboratuarlarında tanı almış kistik ekinokokkozis olgularını retrospektif olarak değerlendirdik. Toplam 26 kistik ekinokkokozis olgusunun 18'i (%69,23) kadın, 8'i (%30,76) erkek hastalardan oluşmuştur. En fazla karaciğer (%57,6) ve akciğer (%19,23) olmak üzere peritoneal bölge, dalak, servikal bölge, kas ve insizyon hattında izlendi. Ayrıca Antakya mezbahasında kesilen sığırlardaki Kistik Ekinokokkozis olgularını da değerlendirdik ve oranı %3,23 olarak bulduk.
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    Massive edema of the ovary : Case report
    (2010) Akansu, Bülent; Atik, Esin; Altıntaş, Süleyman; Güngören, Arif; Canda, M. Şerefettin
    Massive ovarian edema is a rare condition characterized by marked enlargement of one or both ovaries as a result of accumulation of edema fluid in stroma. It is a benign lesion and is generally seen in young females between 6-33 years of age. Our aim is to remind that massive ovarian edema should be considered in the differential diagnosis especially in young patients to avoid aggressive treatment. Our patient was a 17-year-old female who was admitted to our hospital with complaints of irregular menstruation and right groin pain for the last 3 months. There was no remarkable finding in the physical examination. ‘Sex-cord stromal tumor (luteinized thecoma)' could not be excluded in the intraoperative frozen section. The diagnosis was reported as ‘massive ovarian edema' with routine examination. Pathological evaluation is required because of the difficulty of differentiating these lesions from malignant lesions with radiological methods in the pre-operative period. Although it is a rare lesion, clinicians and pathologists should consider it in the differential diagnosis to avoid aggressive treatment.