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    Clinical Significance of Incidental Colonic Focal Lesions Detected by FDG PET/CT
    (Soc Nuclear Medicine Inc, 2015) Elboga, Umut; Sahin, Ertan; Kalender, Ebuzer; Basibuyuk, Mustafa; Demir, Hasan Deniz; Celen, Y. Zeki
    [Abstract Not Available]
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    Clinical Significance of Incidental FDG Uptake in the Prostate Gland Detected by PET/CT
    (Soc Nuclear Medicine Inc, 2015) Sahin, Ertan; Elboga, Umut; Kalender, Ebuzer; Basibuyuk, Mustafa; Demir, Hasan Deniz; Celen, Y. Zeki
    [Abstract Not Available]
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    The Evaluation of Patients with Hyperthyroidism Treated with Radioactive Iodine-131
    (Derman Medical Publ, 2015) Basibuyuk, Mustafa; Elboga, Umut; Celen, Y. Zeki; Kalender, Ebuzer; Demir, H. Deniz; Sahin, Ertan; Ozkaya, Mesut
    Aim: Hyperthyroidism is a condition in which the thyroid gland produces and secretes excessive amounts of the thyroid hormones into circulation. It is one of the common endocrinologic disorders. There are three methods in treatment of hyperthyroidism. These are antithyroid medication, radioactive iodine-131 (RAI) therapy and surgery. In this study, we aimed to evaluate RAI treatment efficacy in patients with hyperthyroidism in the light of laboratory results and clinical pictures. Material and Method: Two hundred and seventy six patients with hyperthyroidism (average age: 50.9 years, age range: 1882 years) who received RAI treatment and then followed up for at least 6 months were included in the study. Patients' medical recordings were analysed retrospectively. Results: Seventy one patients were men (average age: 51.2 years, age range: 18-80 years), the rest were women (average age: 50.7 years, age range: 18-82 years). According to thyroid ultrasound or physical examination findings, 102 patients had diffuse thyroid hyperplasia, the other patients had nondiffuse hyperplasia (nodular or multinodular). RAI was given to the patients once or twice, or three times if necessary. In first RAI treatment, average 13.1 mCi, in second, average 16.6 mCi, in third, average 25 mCi RAI were given orally. Treatment was accepted as successful if the patients had become hypothyroid or euthyroid. Success rate of RAI treatment was 76%. The highest success rate was obtained in patients who have diffuse thyroid hyperplasia. Serious side-effects were not observed in our patients. Discussion: In treatment of hyperthyriodism with RAI in our clinic we observed approximately similar success rates with the reported results in the literature, and also side-effects of RAI treatment were low. We believe that RAI treatment should be first choice for treatment of hyperthyroidism in selected patients, because it is easy to perform and its side- effects are very low.
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    F-18 FDG PET/CT imaging in the diagnostic work-up of thyroid cancer patients with high serum thyroglobulin, negative I-131 whole body scan and suppressed thyrotropin: 8-year' experience
    (Verduci Publisher, 2015) Elboga, U.; Karaoglan, H.; Sahin, E.; Kalender, E.; Demir, H. D.; Basibuyuk, M.; Celen, Y. Zeki
    OBJECTIVE: Fluorodeoxyglucose positron emission tomography/computed tomography imaging in the follow-up of patients with differentiated thyroid carcinoma who have high serum thyroglobulin, negative iodine-131 whole body scan and suppressed thyrotropin. PATIENTS AND METHODS: A total of 90 patients (31 male and 59 female) with differentiated thyroid carcinoma who have high serum thyroglobulin and negative iodine-131 whole body scan were included in the study between July 2006 and March 2014. All patients had undergone surgery (total thyroidectomy +/- lymph node dissection) followed by iodine-131 ablation. Of the patients, 82 had papillary thyroid carcinoma and 8 follicular thyroid carcinoma. Serum thyrotropin was suppressed (< 2 mu IU/ml) during the Fluor-18 fluorodeoxyglucose positron emission tomography/computed tomography imaging procedure. RESULTS: The overall sensitivity of fluor-18 fluorodeoxyglucose positron emission tomography/computed tomography imaging in the detection of metastasis of differentiated thyroid cancer was 84.8%, the specificity 79.1%, respectively. The sensitivity and specificity of fluor-18 fluorodeoxyglucose positron emission tomography/computed tomography imaging in classic type of papillary cancer was 83.3% and 54.5%, respectively. The corresponding figures for the tall cell variant was 85.7% and 87.5%, respectively. The difference between the two histological subtypes was statistically significant (p < 0.05). CONCLUSIONS: Our results suggest that fluor-18 fluorodeoxyglucose positron emission tomography/computed tomography imaging could be a valuable test for the routine follow-up of patients with differentiated thyroid carcinoma.
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    Regional Distributions of Distant Metastases Detected in Differentiated Thyroid Cancers
    (Derman Medical Publ, 2015) Kalender, Ebuzer; Elboga, Umut; Aydogan, Fusun; Basibuyuk, Mustafa; Demir, Hasan Deniz; Sahin, Ertan; Celen, Y. Zeki
    Aim: The aim of our multicenter study is to determine retrospectively the regional distributions of distant metastases which are detected in differentiated thyroid cancers (DTC). Material and Method:Thirty-two of 960 patients with distant metastases who were given radioiodine (RAI) treatment in Gaziantep University School of Medicine and Mustafa Kemal University School of Medicine were included to study. Six of patients were male, 26 of them were female. Mean age was 52 15.4. Hystopathological diagnoses were reported as papillary thyroid cancer in 23 patients and folliculary thyroid cancer in 9 patients. The distant metastasis ratio, metastasis regions and distributions were determined. Results: It was observed only lung metastasis in 18 (56.25 b), only bone metastasis in 6 (18.75 To), combination of lung and bone metastases in 3 (9.4 %), other organ metastases accompanying to bone and lung metastases in 5 (9.4 %) (liver, soft tissue, mediastinum) and multipl organ involvoment in 2 (6.2 96) of patients. It was determined single metastasis region in 24 (75 To), 2 metastasis regions in 6 (18.75 glo) and multipl metastasis regions in 2 (6.25 WO of patients. Discussion: Distant metastases are the biggest problem in treatment and follow-up of DTCs. It is very important to diagnosis of metastases and determine the regions of involvoment in these patients.