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Öğe Assessment of Atrial and Ventricular Mechanics in Patients with Sickle Cell Disease without Overt Pulmonary Hypertension: A Two-Dimensional Deformation Imaging Study(Wiley-Blackwell, 2012) Karakas, Mehmet Fatih; Buyukkaya, Eyup; Kurt, Mustafa; Celik, Murat; Karakas, Esra; Buyukkaya, Sule; Akcay, Adnan Burak[Abstract Not Available]Öğe Assessment of the levels of nitric oxide (NO) in chronic diarrhea patients infected with Giardia intestinalis(Academic Journals, 2012) Kaya, Ozlem M. Aycan; Atambay, Metin; Yula, Erkan; Ozyalin, Fatma; Motor, Vicdan Koksaldi; Motor, Sedat; Celik, MuratGiardia intestinalis is an enteric pathogen causing certain digestive disorders by attaching itself on the human intestine and, especially on the duodenum. It is reported that there is a strong relationship between the nitric oxide (NO) level and the clinical prognosis of the infection in infections of G. intestinalis. The aim of the study was to investigate serum NO levels in samples taken from patients with G. intestinalis detected in the microscopic stool examination and from the control group consisting of healthy people and the presence of any relationship with Giardiosis. The study consisted of 60 patients diagnosed with G. intestinalis in microscopic stool examination, [31 (51.7%) male, 29 (48.3%) female] and 60 healthy people [28 (46.7% male, 32 (53.5%) female] as the control group. All patients in the patient group with gastrointestinal symptoms had chronic diarrhea and cysts and trophozoites were observed in microscopic examination of the feces in all of them. Measurement of serum NO level was performed using Cortas method. When the data were evaluated by T-test in the Independent Groups, NO levels in the patient group was found low at a statistically significant level. In Giardiosis, the decline in the NO level suggested that the disease causes a more severe clinical presentation. In addition to this, we consider it necessary that extensive experimental or clinical studies be conducted on the subject.Öğe Blood Types and Severity of COVID-19(Eurasian Society of Family Medicine, 2021) Ozdemir, Burcu; Ozdemir, Levent; Akgunduz, Bilge; Celik, Murat; Urfali, Senem; Vicdan, Ayse SemaAim: Since blood types first appeared, their association with diseases caused by microorganisms has been further investigated with several studies for many years. The bond of blood groups described as A, B, AB, and O with coronavirus has been the research subject in many countries.We aimed to elucidate whether there was a relationship between blood types and Rh factor and contracting COVID-19 disease and disease severity. Methods: The study was designed as a retrospective case-control study. Between March 2020-February 2021, 1110 patients were included (538 cases, 572 controls). Disease severity was classified according to where patients were treated: those who were outpatients considered as “mild disease”, hospitalized in a hospital ward considered as “moderate disease”, and treated in the intensive care unit were considered as “severe disease”. Results: The number of people with blood type A was 447 (40.3%), blood type B was 197 (17.7%), blood type AB was 90 (%8), and blood type O was 376 (33.9%). There was no significant difference between the case and control groups according to the blood types. A 3.93 times increase of developing mild illness was detected compared to the control group in Rh-positive individuals. The rate of developing a severe disease was higher in females with blood type A than a mild disease, and A blood type caused the disease to be severe compared to other blood groups in females. Conclusion: We concluded that blood type A caused more severe disease than other blood types in females, and females with B blood type survived the disease as outpatients. Our study can shed light on pathophysiological investigation of the relationship between COVID-19 disease causing a pandemic with high mortality and virulence and blood types. © 2021, Eurasian Society of Family Medicine. All rights reserved.Öğe Caffeic acid phenethyl ester (CAPE) protects against acute urogenital injury following pneumoperitoneum in the rat(Taylor & Francis Ltd, 2014) Rifaioglu, Murat Mehmet; Davarci, Mursel; Nacar, Ahmet; Alp, Harun; Celik, Murat; Sefil, Nebihat Kaplan; Inci, MehmetPurpose: Our aim is to determine the biochemical and histologic changes induced in the kidneys, testis and prostate on possible ischemia and reperfusion (I/R) injury caused by pneumoperitoneum (PNP) in a rat model and to evaluate the ability of protective effects of caffeic acid phenethyl ester (CAPE). Methods: Twenty-eight adult male Wistar albino rats were randomly divided to one of three treatment groups, with seven animals in each group. Sham, laparoscopy (L), and laparoscopy plus CAPE (L + C) group were subjected to 60 min of PNP with 15 mmHg one hour before the desufflation period. Total oxidant status (TOS) and total antioxidant status (TAS) levels were determined in kidney, testis, and prostate. Kidney and testis tissues were removed to obtain a histologic score. Also, Johnsen scoring system was used for testicular tissue analysis. Results: L group had significantly higher TOS and lower TAS levels on kidney and testis compared to the other groups. In prostate biochemical analysis, there was not any difference between groups. No difference was found between groups according to kidney and testis tissues' histologic evaluation. In evaluation of Johnsen scoring, L group showed significant lower score compared to the other two groups. Conclusions: Increased intraabdominal pressure (IAP) had an oxidative effect on kidney and testis but not on prostate in rats. Moreover, it could affect the testicular Johnsen score. All these adverse effects of IAP on both kidney and testis could be prevented by CAPE administration.Öğe The Effect of Different Weed Control Treatments On Pharmacological Components of Stigma Quality of Saffron and Diversity of the Microbial Population in Soil(Springer, 2022) Asil, Hasan; Soylu, Soner; Kara, Merve; Celik, Murat; Tasgin, Selim; Celik, Fatma; Uremis, IlhanA two-year study was conducted to determine the efficacy of weed control techniques on the stigma quality of saffron and the diversity of the microbial population in the soil from 2019 to 2021. Several weed control methods are applied to reduce weed competition in saffron (Crocus sativus L.) fields. The impact of fourteen different weed control treatments on the pharmacological components was determined by the GC-MS/MS and GC-MS FID analyses. The highest safranal content in the stigma was recorded from metribuzin treatment with 8.00 mg g(-1), and the lowest was in the pendimethalin + tepraloxydim treatment with 1.26 mg g(-1). The density of the total plant growth promoting bacterial population and the species were defined from the soil around the saffron corms grown in the plots that were applied to the soil treatments. The bacterial species, isolated from the soil samples, were identified using MALDI-TOF analysis. A total of 117 bacterial isolates were obtained from the samples at the root regions of saffron corms The bacterial richness was the highest in the soil sample taken from benfluralin applied with 13 isolates, textile mulch and metribuzin treatments with 12 isolates and sawdust (pine) + benfluralin treatment with 11 isolates. The results showed that the soil treatments used for weed control significantly affected the quality of the saffron stigma, number and population diversities of plant growth promoting endophytic/epiphytic bacteria in the soil and on the corm.Öğe First record of the hydrozoan Oceania armata Kolliker, 1853 from Turkey(Taylor & Francis Ltd, 2016) Gulsahin, Nurcin; Celik, Murat; Turan, Cemal; Ates, Celal[Abstract Not Available]Öğe The Investigation of Total PSA, Free PSA, and Free/Total PSA Ratio in Patients With Liver Cirrhosis Patients According to Child-Pugh Score(Elsevier Science Inc, 2013) Inci, Mehmet; Rifaioglu, Murat Mehmet; Inci, Melek; Celik, Murat; Demir, Mehmet; Ulutas, Turker; Davarci, MurselOBJECTIVE To investigate the total prostate-specific antigen (tPSA), free PSA (fPSA), and free/total PSA (fPSA/tPSA) ratio in patients with liver cirrhosis (LC) according to the severity of hepatic insufficiency. METHODS Eighty-two male patients with LC were studied. The severity of liver disease was categorized by Child-Pugh score (Child-Pugh A, B, and C). Forty-two age-matched healthy subjects were used as a control group. The tPSA, fPSA, fPSA/tPSA ratio, total prostate volume (TPV), total testosterone (TT), and total protein (TP) were measured. The LC group was compared with the control group in terms of these parameters. In addition, intra-comparison and inter-comparison was made between all the Child-Pugh groups and normal subjects, in terms of these parameters. RESULTS The tPSA and fPSA levels in LC cases, Child-Pugh A, Child-Pugh B, and Child-Pugh C groups were significantly decreased compared with the control group. The ratio of fPSA/tPSA in the LC subjects and Child-Pugh A groups significantly increased compared with the control group. TT, TP levels, and TPV in patients with LC were significantly lower compared with the control group and the results were significantly correlated with the Child-Pugh score. CONCLUSION The present study reveals that tPSA and fPSA were decreased in patients with LC in comparison to healthy subjects in terms of 3 mechanisms. First, it might be due to shrunken prostatic volume. Second, it also resulted in decreased levels of testosterone because of the abnormality of hypothalamic-pituitary-testicular axis. Third, it might be the diminished serum protein level in the composition of the PSA. UROLOGY 81: 617-622, 2013. (c) 2013 Elsevier Inc.Öğe Left Ventricular Dyssynchrony is an Early Manifestation of Heart involvement in Sickle Cell Anemia(Wiley-Blackwell, 2012) Karakas, Mehmet Fatih; Buyukkaya, Eyup; Kurt, Mustafa; Celik, Murat; Karakas, Esra; Buyukkaya, Sule; Akcay, Adnan Burak[Abstract Not Available]Öğe M694V and E148Q mutations as potential molecular markers for the diagnosis of familial mediterranean fever among patients in the East Mediterranean region of Turkey(Kamla-Raj Enterprises, 2014) Gok, Ilhami; Oztas, Ozkan; Celik, Murat; Ozic, CemThe purpose of the present study was to estimate frequency of M694V and E148Q mutations in the Mediterranean Fever (MEFV) gene among different families living in the East Mediterranean region of Turkey. A total of 78 members from 19 families, who had the Familial Mediterranean Fever (FMF) disease as diagnosed in clinics, and a control group consisting of 100 members were examined in this work. The member who was clinically diagnosed with FMF gene had attracted the researchers’ focus to take blood examples from the entire family members. The M694V and E148Q are point mutations located in different exons of the affected gene. It is employed PCR method with specific oligonucleotides primers pair to detect mutations in the populations. The gel electrophoresis procedure was used to visualize the presence of point mutations in FMF and control group. The M694V mutation turned to be present in 75 out of 78 members (96%) of 19 FMF-diagnosed families. Among 100 members of the control group, in 26 members 26% carried the M694V. The E148Q mutation was observed in 28 members (35.89%) of the FMF group and 8 members (8%) of the control group. To the extent of the researchers’ knowledge, this is to study target E148Q mutation for FMF gene in Turkey, so this research assumed to have crucial importance in clinics to diagnose FMF gene. © Kamla-Raj 2014Öğe Protective effects of caffeic acid phenethyl ester on dose-dependent intoxication of rats with paraquat(Sage Publications Inc, 2015) Silfeler, Ibrahim; Alp, Harun; Ozgur, Tumay; Evlioglu, Osman; Celik, Murat; Er, Metin; Yilmaz, GulsahPurpose: Paraquat (PQ; 1,1'dimethyl-bipyridilium 4,4'-dichloride), which is used extensively throughout the world, is highly toxic to humans. We aimed to investigate the protective effects of different doses of caffeic acid phenethyl ester (CAPE) on PQ-intoxicated rats. Materials and methods: A total of 80 rats were divided into the following eight groups, comprising 10 rats in each group: group 1: control; group 2: administered with CAPE (10 mu mol/kg); group 3: administered with 15 mg/kg PQ (PQ 15 group); group 4: administered with 30 mg/kg PQ (PQ30 group); group 5: administered with 45 mg/kg PQ (PQ45 group); group 6: administered with 15 mg/kg PQ CAPE; group 7: administered with 30 mg/kg PQ + CAPE and group 8: administered with 45 mg/kg PQ + CAPE. Both PQ and CAPE were injected intraperitoneally. Pancreatic tissue was examined with both haematoxylin and eosin and immunochemical staining. Results: The ratio of the immunohistochemical staining area to the total pancreatic area of the beta cells revealed that statistically significant differences were observed only between the PQ and PQ + CAPE groups (p < 0.05). Discussion: The evaluation of the data suggests that CAPE can be used to prevent acute effects of PQ intoxication.Öğe The relation of fragmented QRS with tissue Doppler derived parameters in patients with b-thalassaemia major(Canadian Soc Clinical Investigation, 2012) Buyukkaya, Eyup; Karakas, Mehmet Fatih; Kurt, Mustafa; Bilen, Perihan; Yalcin, Fatih; Celik, Murat; Helvaci, RamiPurpose: The most important complication encountered in patients with b-thalassaemia major is degenerative fibrosis developing as a result of iron accumulation in myocardial tissue. Dysfunction pursues this accumulation. Recently, presence of fragmented QRS (fQRS) in ECG has been regarded as a predictor of myocardial fibrosis. We aimed in our study to investigate the frequency with which fQRS develops in patients with b-thalassaemia major and to disclose the correlation between fQRS frequency and Doppler-derived indices. Methods: The patients with b-thalassaemia major (n=66; mean age: 23 +/- 6 years) and healthy controls (n=30; mean age: 23 +/- 4 years) were included. fQRS pattern was described as presence of RSR' manifested as existence of additional R wave and notching in either R or S waves in ECG recordings. 2D, M-mode, conventional Doppler, tissue Doppler echocardiography parameters were assessed. Mean serum ferritin levels over past 5 years were also calculated. Results: When compared to those in control group, fQRS was more frequent in b-thalassaemia major group, indicating statistical significance (p = 0.001). While E/Em and ferritin level exhibited statistically significant increase in thalassaemia patients with fQRS (p < 0.05), the mean Em and Sm values were found to be significantly low (p < 0.05). Conclusions: fQRS was frequently observed in the patients with b-thalassaemia major, which was of statistical significance. Tissue Doppler-derived diastolic and systolic indices in thalassaemia cases with fQRS showed statistically significant impairment compared to those without fQRS. In conclusion, fQRS may represent a novel noninvasive marker for cardiac involvement in patients with b-thalassaemia major.
