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Öğe Age-related Prevalence of Toxoplasmosis Among Pregnant Women in Hatay: Estimation Depending on Model(Ankara Microbiology Soc, 2017) Cetin, Meryem; Cetin, SirinToxoplasmosis, caused by the obligate intracellular protozoan Toxoplasma gondii, is a common parasitic infection affecting approximately one-third of the world population. T. gondii infections are usually acquired by ingesting raw or insufficiently cooked meat and from unwashed fruits and vegetables contaminated with soil or water with cat feces. Primary infection acquired during pregnancy can cause severe congenital abnormalities in the fetus such as neurologic and ocular malformations, abortion, or stillbirth according to the degree of infection. The aim of this study was to estimate the prevalence and rate of seroconversion of T. gondii IgG antibodies in a selected population of pregnant women in Hatay by using a mathematical model. T. gondii-specific serological screening test results of 11.564 pregnant women who have attended the Private Antakya Mosaic Obstetrics and Gynecology Hospital between 01.04.2009 and 31.04.2016 were analysed in the study. The prevalence of T. gondii-specific IgG antibodies in the studied population were found as 48.70% (95% CI, 0.48-0.50). The prevalence of T. gondii-specific IgG antibodies were increased linearly with age in our study population. The relationship between age and prevalence was statistically significant (p<0.001). The age-specific rate of seroconversion was estimated as 0.8% for T. gondii infection in pregnant women. It was observed that the rate of T. gondii-specific IgG antibodies decreased from 55.12% (95% CI, 0.52-0.57) detected in 2009 to 42.22% (95% CI, 0.37-0.46) in 2016. The estimated number of cases carrying the risk of primer T. gondii infection was calculated as 69 in the study population. Our results have suggested that the prevalence of T. gondii-specific antibodies is high among pregnant women in Hatay. Early maternal diagnosis and treatment methods may reduce the risk of transplacental transmission during pregnancy. The on time diagnosis can only be achieved with prenatal serological screening. The knowledge of the incidence and prevalence of toxoplasma infection in pregnant women plays a crucial role in estimating the burden of the disease and evaluating the effectiveness of the public health protection policies including screening programmes. Expanding of training activities, drawing attention to hygiene, taking nutritional precautions and increasing awareness of toxoplasmosis in pregnant women are important to prevent congenital toxoplasmosis or minimize the disease.Öğe Awareness and Knowledge Levels of 18-Year-Old and Older Individuals Regarding Human Papillomavirus (HPV) and HPV Vaccine in Hatay, Turkey(Springer, 2019) Turhan, Ebru; Cetin, Sirin; Cetin, Meryem; Abacigil, FatmaThe aim of this study was to evaluate the knowledge and awareness levels of 18-year-old and older women and men on HPV infection, HPV vaccine, and the potential risk factors in Hatay, Turkey. In our study, it was found that overall 27.0 and 23.2% of the participants reported having heard of HPV infection and HPV vaccine. The rate of participants who had heard of HPV infection and HPV vaccine was higher in women than in men (p < 0.000). Thirteen percent of the participants was aware of the fact that HPV triggers cervical cancer, 10.2% penile cancer, and 16.7% genital warts, respectively. The overall vaccination rate of the participants was 2.7%. When the total knowledge score of the participants about HPV infection and HPV vaccine was evaluated according to independent variables, it was found that being a woman, urbanization, and having a high level of education had a positive effect on knowledge score, while never having heard of HPV infection and HPV vaccine had a negative effect on knowledge score (p < 0.000). It was determined in the linear regression model that gender, educational status, residential area, and having heard of HPV infection before influenced knowledge levels. It was determined that the relation between these variables and the total knowledge scores of the participants was statistically significant (p < 0.05). It was also determined that women who had higher educational levels, those who were living in urban areas, and those who had heard HPV infection before had higher knowledge levels. The level of knowledge of the participants about HPV infection and HPV vaccine was found to be very low. Having adequate knowledge about HPV infection and increasing the acceptance of HPV vaccination in public will play an important role in decreasing the rate of mortality and morbidity of the different HPV-associated cancers in women and men.Öğe Prognostic value of the neutrophil-to-lymphocyte ratio and carbohydrate antigen 19-9 in estimating survival in patients with metastatic pancreatic cancer(Wolters Kluwer Medknow Publications, 2020) Cetin, Sirin; Dede, IsaBackground: The predictive value of different prognostic biomarkers has been studied in various cancer types. Aims and Objectives: The purpose of this study was to examine the degree of risk and prognostic significance of pretreatment neutrophil-to-lymphocyte ratio (NLR) and carbohydrate antigen (CA) 19-9 levels in patients with metastatic pancreatic cancer (PC) and reveal its relevance with survival. Materials and Methods: Clinical and laboratory data of 118 patients with metastatic PC at the time of diagnosis were retrospectively analyzed. The overall survival (OS) was estimated according to the Kaplan-Meier method. To determine the prognostic factors affecting PC, the Cox regression analysis was performed. Results: The average age of the patients was 67 +/- 9.57 years. The patients were analyzed during the follow-up period, and their average OS was 12 months (95% confidence interval [CI] = 9.73-14.26). The cutoff value was 3.54 (area under the curve [AUC] = 0.653, 95% CI = 0.56-0.73, P = 0.006) for NLR and 437 (AUC = 0.670, 95% CI = 0.57-0.75, P = 0.002) for CA19-9. Statistically significant difference was found between CA19-9 (P < 000.1) and NLR (P < 000.1) and OS. Analysis of multivariate Cox regression showed that NLR (hazard ratio [HR] = 2.17, 95% CI = 1.17-4.03, P = 0.013) and CA19-9 (HR = 1.81, 95% CI = 1.08-3.03, P = 0.022) were important prognostic factors in OS analysis. Conclusion: Pretreatment NLR and CA19-9 levels were found to be reliable estimative markers for poor prognosis in patients with metastatic PC. Our findings revealed that NLR and CA19-9 levels can be used to estimate the survival of patients with PC. We believe that our findings will shed light on the management of treatment protocols for patients diagnosed with metastatic PC.Öğe Seroprevalence of hepatitis B surface antigen and associated risk factors among pregnant women(J Infection Developing Countries, 2018) Cetin, Sirin; Cetin, Meryem; Turhan, Ebru; Dolapcioglu, KenanIntroduction: Hepatitis B infection is a serious global public health problem. The aim of the study was to assess the seroprevalance of hepatitis B surface antigen (HBsAg), as well as the risk factors associated with hepatitis B virus (HBV) infection among pregnant women attending antenatal care clinics of the University Hospital in Antioch, Turkey. Methodology: This descriptive cross-sectional study was carried out between May 2016 and December 2016. The Chi-squared was utilized to estimate the statistical significance of the association between socio-demographic variables and HBsAg status. The results were generated as proportions odds ratio (OR) with their 95% confidence intervals (Cl) and calculated by using both univariate and multivariate logistic regression analysis. Results: The semprevalence of HBsAg was found to be 2.1%. A significant association was observed between age and HF3sAg seropositivity (p = 0.027). History of blood transfusion (AOR = 9.51, 95% CI = 1.92-46.80, p = 0.006), history of hepatitis (AOR = 11.13, 95% CI = 2.02-61.28, p = 0.006), tattooing (AOR = 13.64, 95% CI = 2.52-73.76, p = 0.002) and a history of household/close contact (AOR = 11.10, 95% CI = 1.56-78.65, p = 0.016) were significantly associated with the risk of HBV infection. Conclusions: Data regarding the seroprevalence of HBsAg and risk factors associated with HBV infection in pregnant women plays a crucial role in evaluating the effectiveness of the public health protection policies and the strategies to control the disease.
