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Öğe Comparison of Mean Platelet Volume Values between Patients with Nasal Polyp and Healthy Individuals(Galenos Yayincilik, 2013) Cevik, Cengiz; Yengil, Erhan; Akbay, Ercan; Arli, Cengiz; Gulmez, Mehmet Ihsan; Akoglu, ErtapObjective: Nasal Polyp (NP) and Allergic Rhinitis (AR) are frequently seen in common. It has been reported that there is an increase in the risk of atherosclerosis in allergic patients. In our study, we aimed to evaluate Mean Platelet Volume (MPV) values in patients with NP, which is used as a marker of atherosclerosis. Methods: Seventy-five patients who underwent functional endoscopic sinus surgery (FESS) with a diagnosis of NP were reviewed. Seventy-five age-matched healthy individuals without AR made up the control group. Val-ues of white blood cell (WBC), platelet (PLT), hemoglobilin (Hb) and MPV were evaluated. Results: MPV values were found to be low in patients with NP 7.89 +/- 1.02 fL compared to control group 8.32 +/- 1.42 fL. This finding was statistically significant. Conclusion: It was found that MPV values are significantly low in patients with NP than control group.Öğe Comparison of the result of consolidative technique otoplasty and incisionless otoplasty in the repairs of prominent ears(Springer, 2016) Temel, Metin; Kahraman, S. Samil; Berber, Ozge; Cevik, Cengiz; Akoglu, ErtapWe aimed to compare the long-term results of complications of consolidative technique otoplasty (CTO) and incisionless otoplasty (IO). The study consists of 156 patients who were operated between 2006 and 2015. According to surgical techniques, these patients were divided into two groups as IO group and CTO group. The distance between the head and the ear was assessed by measuring the four points preoperatively and postoperatively (SUP: most superior helical point, SCA: superior conchal attachment, ICA: inferior conchal attachment, and lobule). Early and late postoperative complications, operative time were recorded. 128 ears in IO group, 163 ears in CTO group were prominent. When postoperative SUP, SCA, ICA, lobule values for right and left ears in both groups were statistically evaluated, it was found that CTO technique has led to significantly greater improvement compared to the IO technique (p < 0.001). The success rate in IO technique and CTO technique was 72 and 96 %, respectively. Early complications were similar in both groups. The late period complication determined much more frequently was seen in the IO group. Concerning operative time, it was identified as significantly lower in the IO group (p < 0.001). The early-term outcomes of both techniques were similar; however, the complication rates due to suture material and needed for revision in IO technique were higher whereas CTO technique was more permanent with lower complication risks.Öğe CORRESPONDING ERDOSTEINE CHANGES AUTOPHAGY GENES EXPRESSION IN HIPPOCAMPUS ON RHINITIS MEDICAMENTOSA MODEL(Serbian Genetics Soc, 2015) Dokuyucu, Recep; Gogebakan, Bulent; Cevik, CengizIn our study, rats were subjected to Oxymetazoline hydrochloride treatment and Rhinitis medicamentosa (RM) was formed and then autophagy gene expression levels were determined after the application of an antioxidant agent erdosteine (ED). The rats were divided into three groups; Group 1 was the control group. Group 2 (RM) and group 3 (RM+ED) rats received two spray puffs of 0.05% oxymetazoline into the nasal cavities three times daily for eight weeks. After determination of RM in the rats, the RM group were killed. The ED+RM group received 10 mg/kg of an ED suspension. At the end of seven days, these rats were also killed. All groups' hippocampus tissues were obtained for the measurement of autophagy gene expressions. In rhinitis medicamentosa group Atg5, Atg7 and Atg10 gene expressions in the left hippocampus were reduced as compared to control group (p=0.01, p>0.05, p=0.01, respectively). Also, erdosteine treatments were restored mRNA expression of autophagy genes. In right hippocampus of rhinitis medicamentosa group, Atg5 and Atg10 gene expressions was found to be down-regulated as compared to control group (p>0.05, p<0.05, respectively). Both BECN1 and ULK genes expression were found to be reduced in left hippocampus of rhinitis medicamentosa group. Erdosteine applications was restored the expression of these genes (p=0.03, p=0.03, respectively). Additionally, in right hippocampus, Erdosteine application was restored the expression of ULK gene (p=0.01). This is the first report that evaluated the expression autophagy genes in RM rat models and the changes observed after erdosteine applications.Öğe Determination of hearing levels in patients with Familial Mediterranean Fever(2013) Cevik, Cengiz; Silfeler, Ibrahim; Arica, Vefik; Yengil, Erhan; Akbay, Ercan; Sarac, Tuba; Basarslan, FatmagulObjective: Familial Mediterranean Fever is the most common congenital, periodic fever condition that affects over 100,000 people worldwide. In the literature, there is limited number of studies about hearing levels in children with Familial Mediterranean Fever. In the present study, we aimed to investigate hearing levels and cochlear functions by using Distortion product Otoacoustic Emission and High Frequency Audiometry (250-20,000. Hz) in pediatric patients with Familial Mediterranean Fever. Methods: The study included 62 children with Familial Mediterranean Fever and 27 healthy children with similar age and gender. After otoscopic examination, both groups underwent audiological evaluation including High Frequency Audiometry (250-20,000. Hz) and Distortion product Otoacoustic Emissions. The results obtained were assessed among groups. In addition, these results were compared regarding colchicine use, age at the onset of disease and duration of the diseases in the Familial Mediterranean Fever group. Results: Of the Familial Mediterranean Fever patients, 93.5% were on colchicine therapy and mean duration of colchicine use was 19.9 ± 13.9 months. The mean age at diagnosis was 6.57 ± 2.86 years (min-max: 2-14) and mean duration of disease was 23 ± 17 months (min-max: 6-84). Pure tone audiometry values, and hearing levels between 9000 and 20,000. Hz were similar and within normal range in both groups. The Distortion product Otoacoustic Emissions responses at the frequencies of 1020, 2040, 3000, 4080 and 5040. Hz were similar for both groups. Conclusion: To the best of our knowledge, this is the first study evaluating hearing levels at the frequencies of 18. kHz and 20. kHz in children with Familial Mediterranean Fever in the literature. In children with Familial Mediterranean Fever, Pure tone audiometry values, hearing values obtained at all frequencies from 250 to 20,000. Hz, and Distortion product Otoacoustic Emissions levels were within normal range. Furthermore, hearing levels were found to be similar to those in healthy children. © 2013 Elsevier Ireland Ltd.Öğe Determination of oxidative stress and effect of erdosteine on rhinitis medicamentosa in a rat model(Elsevier Science Bv, 2014) Dokuyucu, Recep; Cevik, Cengiz; Ozler, Gul Soylu; Ozgur, Tumay; Arli, Cengiz; Sefil, Fatih; Yonden, ZaferWe aimed to determine the presence of oxidative stress in rhinitis medicamentosa (RM) and to evaluate the effect of erdosteine (ED) on mucosal changes in a rat model. Twenty-four male rats were used in this experimental study. Three groups were created. Group 1 (n=8) was the control group. Two puffs of 0.05% oxymetazolin were sprayed into the nasal cavities of the remaining rats (n = 16) three times daily for eight weeks. One of these 16 rats was scarified at the end of the eight weeks and examined to confirm the presence of RM. Seven of the remaining 16 rats were killed, and venous blood samples were taken (Group 2). Group 3 (n=8) received 10 mg/kg of an ED suspension orally for seven days. All rats were put on formalin for light microscopy. The total antioxidant status (TAS) was similar in all groups (p = 0.073). The total oxidative status (TOS) of the RM group was significantly higher than that of the control group and RM + ED group (Group 3) (p = 0.003 and p = 0.011, respectively). The pathological recovery of the nasal mucosa of the rats was similar in the RM + ED and control groups. The TOS was high in this RM rat model, and oxidative stress was associated with RM. ED significantly ameliorated nasal mucosal changes induced by RM, suggesting that oxidative stress may play an important role in the pathophysiology of this condition. (C) 2014 Elsevier B.V. All rights reserved.Öğe Effect of carboxyhemoglobin on postoperative complications and pain in pediatric tonsillectomy patients(Wiley, 2015) Koyuncu, Onur; Turhanoglu, Selim; Tuzcu, Kasim; Karcioglu, Murat; Davarci, Isil; Akbay, Ercan; Cevik, CengizBackground: Carbon monoxide (CO) is a product of burning solid fuel in stoves and smoking. Exposure to CO may provoke postoperative complications. Furthermore, there appears to be an association between COHb concentrations and pain. We thus tested the primary hypothesis that children with high preoperative carboxyhemoglobin (COHb) concentrations have more postoperative complications and pain after tonsillectomies, and secondarily that high-COHb concentrations are associated with more pain and analgesic use. Methods: 100 children scheduled for elective tonsillectomy were divided into low and high carbon monoxide (CO) exposure groups:COHb 3 or 4gdl(-1). We considered a composite of complications during the 7days after surgery which included bronchospasm, laryngospasm, persistent coughing, desaturation, re-intubation, hypotension, postoperative bleeding, and reoperation. Pain was evaluated with Wong-Baker Faces pain scales, and supplemental tramadol use recorded for four postoperative hours. Results: There were 36 patients in the low-exposure group COHb [1.81.2gdl(-1)], and 64 patients were in the high-exposure group [6.4 +/- 2.1gdl(-1)]. Indoor coal-burning stoves were reported more often by families of the high- than low-COHb children (89% vs 72%, P<0.001). Second-hand cigarette smoke exposure was reported by 54% of the families with children with high COHb, but only by 24% of the families of children with low COHb. Composite complications were more common in patients with high COHb [47% vs 14%, P=0.0001, OR:7.4 (95%Cl, lower=2.5-upper=21.7)], with most occurring in the postanesthesia care unit. Pain scores in postanesthesia care unit and one hour after surgery were statistically significantly lower in the low-exposure group [respectively, P=0.020 (95%CI, lower=-1.21-upper=-0.80), P=0.026 (95%CI, lower=-0.03-upper=0.70)], and tramadol use increased at 4h (3.5 (interquartile range: 0-8) vs 6 (5-9) mg, P=0.012) and 24h (3.5 (0-8) vs 6 (5-9) mg, P=0.008). Conclusion: High preoperative COHb concentrations are associated with increased postoperative complications and pain.Öğe The Effect of Erdosteine on Autophagy Genes Expression in Hippocampus on Rhinitis Medicamentosa Model(Wiley-Blackwell, 2015) Dokuyucu, Recep; Gogebakan, Bulent; Cevik, Cengiz[Abstract Not Available]Öğe The effect of width of facial canal in patients with idiopathic peripheral facial paralysis on the development of paralysis(Springer, 2015) Eksi, Guldem; Akbay, Ercan; Bayarogullari, Hanifi; Cevik, Cengiz; Yengil, Erhan; Ozler, Gul SoyluThe aim of this prospective study is to investigate whether the possible stenosis due to anatomic variations of labyrinthine segment (LS), tympanic segment (TS) and mastoid segment (MS) of the facial canal in the temporal bone is a predisposing factor in the development of paralysis. 22 patients with idiopathic peripheral facial paralysis (IPFP) were included in the study. Multi-slice computed tomography (MSCT) with 64 detectors was used for temporal bone imaging of the patients. Reconstruction images in axial, coronal and sagittal planes were created in workstation computers from the captured images. The diameters and lengths of LS, TS and MS of the facial canal were measured. The mean values of LD, ND and SL of LS were 1.31 +/- A 0.39, 0.91 +/- A 0.27, 4.17 +/- A 0.48 in patient group and 1.26 +/- A 0.29, 0.95 +/- A 0.21, 4.60 +/- A 1.36 in control group, respectively. The mean values of LD, ND and SL of TS were 1.11 +/- A 0.22, 0.90 +/- A 0.14, 12.63 +/- A 1.47 in patient group and 1.17 +/- A 0.23, 0.85 +/- A 0.24, 12.10 +/- A 1.79 in control group, respectively. The mean values of LD, ND and SL of MS were 1.80 +/- A 0.30, 1.44 +/- A 0.29 vs. 14.3 +/- A 1.90 in patient group 1.74 +/- A 0.38, 1.40 +/- A 0.29, 14.15 +/- A 2.16 in control group, respectively. The measurements of the parameters of all three segments in patient group and control group were similar. Similar results between patient and control group were obtained in this study investigating the effect of stenosis in facial canal in the development of IPFP.Öğe Higher frequency of methicillin resistant bacteria in children with familial mediterranean fever(Pakistan Medical Assoc, 2015) Yengil, Erhan; Cevik, Cengiz; Silfeler, Ibrahim; Yula, Erkan; Kurtoglu, Ibrahim Ahmet; Arica, Vefik; Ozer, CahitObjective: To investigate resistant microorganisms in nasal mucosa of children with Familial Mediterranean Fever. Methods: The study was conducted from March to May 2013 at Mustafa Kemal University, Turkey, and comprised children with Familial Mediterranean Fever and healthy controls. All subjects had no history of antibiotic or local and/or systemic steroid use within the preceding 2 weeks. Nasal swab samples were obtained from all the subjects. Strain identification was done by using standard methods. SPSS 13 was used for statistical analysis. Results: Of the 151 subjects in the study, 73(48.34%) were cases and 78(51.65%) were controls. Among the cases, there were 26(35.6%) girls, while among the controls, there were 40(51.3%) girls (p=0.052). The mean age of the cases was 7.78+/-3.34 years (range: 3-15 years), while it was 8.15+/-2.71 years (range: 3-16) among the controls (p=0.208). Methicillin-resistant coagulase-negative staphylococcus and methicillin-resistant staphylococcus aureus were isolated in both the groups. The growth rate of resistant bacteria was 63% (n=46) in the cases, in the controls (p=0.003; odds ratio [OR]: 2.7; 95% confidence interval [CI]: 1.4-5.2). Among the controls, history of hospitalisation increased the risk for the presence of resistant bacteria by 7.7 fold (OR: 7.7; 95%CI: 1.4 - 40.4). Conclusion: Higher rates of resistant bacteria showed that they were at risk of comorbidities related to antibiotic resistance.Öğe Identification of nasal bacterial flora profile and carriage rates of methicillin-resistant Staphylococcus aureus in patients with allergic rhinitis(Springer, 2014) Cevik, Cengiz; Yula, Erkan; Yengil, Erhan; Gulmez, M. Ihsan; Akbay, ErcanThe aim of the present study was to evaluate the effect of allergic rhinitis (AR) on the nasal flora and colonization rates of resistant microorganisms in comparison to healthy individuals. This colonization may be important in terms of AR-related disorders, the resistant microorganisms' carriage, and its complications and co-morbidities. The study was performed with two groups. The study group was composed of 54 adult patients with AR. The control group was composed of 50 healthy individuals. None of the individuals in both groups have used any antibiotics, local or systemic steroid within the last month. Composition of bacterial nasal flora and carriage rates of methicillin-resistant Staphylococcus aureus (MRSA) were evaluated with conventional methods by taking nasal smears with a swab. In the study group, methicillin-sensitive coagulase-negative staphylococci (MRCNS) were detected in 30 %; whereas diphtheroids in 25 %, methicillin-resistant coagulase-negative staphylococci in 13 %, methicillin-sensitive S. aureus in 9 %, methicillin-resistant S. aureus in 3.7 %, and extended-spectrum beta lactamases-positive gram-negative bacilli (GR-ESBL+) in 3.7 % were detected. In the control group, methicillin-sensitive coagulase-negative staphylococci were detected in 54 %; whereas diphtheroids in 21 %, methicillin-resistant coagulase-negative staphylococci in 1.5 %, methicillin-sensitive S. aureus in 16 %, methicillin-resistant S. aureus in 1.5 %, Gr-ESBL(-) in 4 %, and viridians streptococci in 3 % were detected. It is found that the MRSA and MRCNS colonization is higher in patients with AR. This colonization may be important in terms of AR-related disorders, the resistant microorganisms' carriage, and its complications and co-morbidities in comparison to healthy subjects.Öğe Mean Platelet Volume Evaluation in Patients with Nasal Polyp: Methodological Drawbacks Reply(Galenos Yayincilik, 2015) Cevik, Cengiz; Yengil, Erhan; Akbay, Ercan; Arli, Cengiz; Gulmez, Mehmet Ihsan; Akoglu, Ertap[Abstract Not Available]Öğe A novel tumor suppressor gene in basal cell carcinoma: inhibition of growth factor-2(Springer, 2015) Temel, Metin; Turkmen, Arif; Dokuyucu, Recep; Cevik, Cengiz; Oztuzcu, Serdar; Cengiz, Beyhan; Mutaf, MehmetIn loss of heterozygosity (LOH) studies at the chromosome 4q22-35 region, it was shown that the amount of deletion was high in basal cell carcinoma (BCC). It has been proposed that genes located in this chromosomal region could be tumor suppressor genes in BCC. It has been thought that deletions in the ING2 gene located in the same region can play a role in the pathophysiology of BCC and that deletions occurring in this region may influence the level of ING2 expression in BCC. Tumoral and non-tumoral tissues from 75 patients with BCC (45 men and 30 women) were included to the study. Lesions were excised by a surgical margin of 0.5 cm. After excision, RNA was isolated from tumoral and non-tumoral tissue samples. ING2 messenger RNA (mRNA) expression level was determined in tumoral and non-tumoral tissues by the real-time polymerase chain reaction (RT-PCR). It was detected that ING2 mRNA expression level decreased in tumoral tissues when compared to non-tumoral tissues from BCC patients (p = 0.0001). It was found that expression levels of this gene were comparable among patients with primary, recurrent, or multiple BCC. It is thought that ING2 gene expression level could contribute to the development of BCC but not be associated with the stage and the prognosis of the tumor.Öğe Oxidative stress in chronic otitis media(Springer, 2013) Baysal, Elif; Aksoy, Nurten; Kara, Ferit; Taysi, Seyithan; Taskin, Abdullah; Bilinc, Hasan; Cevik, CengizChronic otitis media usually presents with a benign tumor-like lesion of the temporal bone known as a cholesteatoma. The role of oxidative stress in the pathogenesis of chronic otitis media and cholesteatoma has not yet been fully explored. Therefore, the aim of this study was to investigate the oxidative stress markers and antioxidant enzymes in patients with cholesteatomatous and noncholesteatomatous chronic otitis media and in healthy subjects. A prospective controlled trial was performed on cholesteatomatous and noncholesteatomatous chronic otitis media patients in a tertiary referral center in a university hospital. A total of 75 subjects, including 25 cholesteatomatous and 25 noncholesteatomatous chronic otitis media patients and 25 healthy subjects participated in this study. Serum total oxidant status (TOS) and oxidative stress index (OSI) levels were significantly increased in the patient groups with or without cholesteatoma compared with the control group. Serum total antioxidant status (TAS) levels and Paraoxonase and arylesterase activity were significantly lower in the patient groups with or without cholesteatoma compared with the control group. Serum TOS and OSI levels were lower in the noncholesteatomatous group, whereas serum TAS levels were higher compared with the cholesteatomatous group. Serum arylesterase activity was significantly lower in the noncholesteatomatous group compared with the control group. The results of this study reveal that in cholesteatoma cases, the oxidative stress and antioxidant enzyme imbalance were more significant than in cases of chronic otitis media without cholesteatoma.Öğe Perioperative Difficulties and Early Postoperative Complications of Transoral Approach in Mouth Base Surgery(Lippincott Williams & Wilkins, 2014) Akbay, Ercan; Cevik, Cengiz; Arli, CengizObjective The aim of this study was to discuss perioperative difficulties and temporary or permanent complications that can be seen at early postoperative period in cases undergoing transoral surgical approach for disorders of mouth base. Study Design The study included 19 patients undergoing transoral surgical approach between September 2011 and January 2013 who were retrospectively evaluated. Exclusion criteria were patients with malign submandibular gland tumor or other suspected tumors at mouth base, those with a benign solid mass larger than 10 x 10 cm, and those who did not accept the transoral approach. Results Mean age was 28.47 17.89 years (range, 8-76 years) in 19 patients included (9 male and 10 female subjects). Of these, submandibular gland excision was performed in 9 cases, whereas thyroglossal duct cyst excision was performed in 3 (2 transfrenulum approach and 1 lateral lingual approach), lymphangioma excision in 1, diagnostic lymph node excision at the posterior of submandibular gland in 3 cases, and dermoid cyst excision (2 with midline and 1 with left submandibular localization) in 3 cases. Perioperative difficulties included dissection problems due to adhesion, partial adhesion between Wharton canal and lingual nerve, fragmented dissection of the gland, capsule rupture of submandibular adenoma, and facial artery rupture. While visualization of surgical field and retraction of mouth base muscles are an important issue in midline approaches, resection of hyoid bone corpus is challenging in lateral approaches. Early postoperative complications included edema at mouth base, lingual ecchymosis, and postoperative temporary abnormal tongue sensation. Conclusions Transoral mouth base surgery is a safe approach in selected patients. Permanent injuries of neural structures are rarely encountered, which is considered as a concern by head and neck surgeons. Temporary complications are at a level that can be tolerated by patients.Öğe Pseudoaneurysm of the Carotid Arterial System(Lippincott Williams & Wilkins, 2014) Bayarogullari, Hanifi; Acipayam, Mehmet; Akbay, Ercan; Atci, Nesrin; Davran, Ramazan; Cevik, CengizPseudoaneurysms of internal, external, and common carotid arteries are seen rarely. Blunt traumas caused by automobile accidents are the prior reasons to this. Central venous catheterization, ballistic trauma, cystic medial necrosis, fibromuscular dysplasia, atherosclerosis, and other inflammatory processes are some other potential reasons for pseudoaneurysm. In contrast to true aneurysms, it does not contain 3-layer structure with adventitia, media, and intima sublayers in its wall. The wall contains coagulum and fibrous capsules. Clinically, after trauma, it presents itself as swelling after days to weeks of damage to vascular walls. Because it causes morbidity and mortality when it is ruptured, It should be treated via surgical or vascular intervention.Öğe A rare complication of acute otitis media: A 6-month old infant with peripheral facial paralysis(Dr Behcet Uz Cocuk Hastaliklari Ve Cerrahisi, 2013) Cevik, Cengiz; Tutanc, Murat; Silfeler, Ibrahim; Akbay, Ercan; Alakus, UmmuOtitis media is the second most common infectious disease of childhood, which is defined as clinical presentation that occurs due to inflammation of middle ear. It has been reported that Streptococcus pneumonia, Hemophilus influenzea and Moraxella catarrhalis are the causative agents accounted for acute otitis media (AOM). It is most commonly seen between 6 and 24 months of age. Although AOM is a commonly encountered disease in children, peripheral facial paralysis (PFP) is an uncommon complication of AOM. Most common cause of PFP is Bell's paralysis in children. A child, who had a history of AOM following upper tract infection and presented with PFP (Grade III according to Hause-Brackman classification) on the 3rd day of infection, was admitted to hospital and IV antibiotic therapy was given. One-week steroid therapy was initiated during follow-up period. At the end of 2nd month, PFP was completely recovered by medical treatment. In the present study, we aimed to call attention to a rare complication of AOM, facial paralysis, in this 6-month-old girl.Öğe Rare Tumours and Tumour-like Lesions of Pharynx That Cause Dysphagia(Galenos Yayincilik, 2013) Bayarogullari, Hanifi; Cevik, Cengiz; Akbay, Ercan; Cokkeser, YasarObjective: The aim of this article is to discuss rarely encountered tumours and tumorous masses at the different levels of pharynx that were diagnosed in patients admitted to our hospital with the complaint of dysphagia. Methods: Twenty-one cases with masses causing dysphagia at the oropharyngeal, hypo-pharyngeal and laryngeal levels were identified among patients admitted to our hospital with the complaint of difficulty with swallowing between the years 2009 and 2011. Detailed anamneses and physical examinations were performed. In addition, for the purpose of diagnosis, the following were applied: Magnetic Resonance Imaging with and without contrast, Computerized Tomography, Three-Dimensional Computerized Tomography, Multiple row-Detector Computerized Tomography, MR Angiography and 99m Tc Scintigraphy. Results: Twenty-one patients, 12 women (57.1%) and 9 men (42.9%), were included in the study. Their mean age was 49.23 +/- 32.71 years old (min. 15-max. 80). There was partial obstruction at the oropharyngeal level in 11 cases; there was partial obstruction at the laryngeal and hypopharyngeal level in the other 10 cases. Conclusion: A detailed history and examination along with endoscopic, radiological and laboratory evaluations are important for early diagnosis and management of rare tumours and tumour-like lesions of the oropharynx and neck causing dysphagia.Öğe Relationship between demodex folliculorum and allergic rhinitis in adults(Acta Medica Mediterranea, 2014) Yengil, Erhan; Cevik, Cengiz; Kaya, Ozlem Aycan; Taner, Melis; Neslin Akkoca, Ayse; Ozer, CahitBackground and aim: Allergic rhinitis (AR) is a chronic disease, which exhibits rapid increase in recent years and affects approximately 30-40% of the population worldwide. Demodex folliculorum (DF) is an ectoparasite, which is prevalent in human skin. The aim of the present study was to investigate the frequency of DF at eyelashes and cheek in patients with allergic rhinitis and controls. Materials and methods: The study included 63 patients with allergic rhinitis and 65 healthy individuals. For DF evaluations, 4 eyelashes were taken from all individuals. Five samples of standardized skin surface biopsies (SSSB) were taken from each subject from the forehead, cheeks, jaw and nose. Results: For eyelashes, the frequencies of DF were found as 50.8% in AR group, whereas 38.1% in control group. For face, it was found as 38.1% in AR group, whereas 12.3% in control group. The frequencies of DF at face and eyelashes were found to be significantly higher in patients with AR than controls (p=0.001 and p=0.0001, respectively). The DF was detected at eyelashes in 63.9% of the patients with ocular symptoms vs. 33.3% of those without (OR: 3.5 (95% CI: 1.2-10.1); p=0.016), whereas it was detected at face in 52.8% of the patients with ocular symptoms vs. 18.5% of those without (OR: 4.9 (95%CI: 1.5-15.8); p=0.008). Conclusion: The frequencies of DF at eyelashes and face were significantly higher in patients with AR than healthy individuals. The higher frequency of DF in patients with AR suggests that AR facilitate the colonization of this mite.Öğe RELATIONSHIP BETWEEN DEMODEX FOLLICULORUM AND ALLERGIC RHINITIS IN ADULTS(Carbone Editore, 2014) Yengil, Erhan; Cevik, Cengiz; Kaya, Ozlem Aycan; Taner, Melis; Akkoca, Ayse Neslin; Ozer, CahitBackground and aim: Allergic rhinitis (AR) is a chronic disease, which exhibits rapid increase in recent years and affects approximately 30-40% of the population worldwide. Demodex folliculorum (DF) is an ectoparasite, which is prevalent in human skin. The aim of the present study was to investigate the frequency of DF at eyelashes and cheek in patients with allergic rhinitis and controls. Materials and methods: The study included 63 patients with allergic rhinitis and 65 healthy individuals. For DF evaluations, 4 eyelashes were taken from all individuals. Five samples of standardized skin surface biopsies (SSSB) were taken from each subject from the forehead, cheeks, jaw and nose. Results: For eyelashes, the frequencies of DF were found as 50.8% in AR group, whereas 38.1% in control group. For face, it was found as 38.1% in AR group, whereas 12.3% in control group. The frequencies of DF at face and eyelashes were found to be significantly higher in patients with AR than controls (p=0.001 and p=0.0001, respectively). The DF was detected at eyelashes in 63.9% of the patients with ocular symptoms vs. 33.3% of those without (OR: 3.5 (95% CI: 1.2-10.1); p=0.016), whereas it was detected at face in 52.8% of the patients with ocular symptoms vs. 18.5% of those without (OR: 4.9 (95%CI: 1.5-15.8); p=0.008). Conclusion: The frequencies of DF at eyelashes and face were significantly higher in patients with AR than healthy individuals. The higher frequency of DF in patients with AR suggests that AR facilitate the colonization of this mite.Öğe The relationship between posterior septum deviation and depth of maxillopalatal arch(Elsevier Sci Ltd, 2013) Akbay, Ercan; Cokkeser, Yasar; Yilmaz, Omer; Cevik, CengizObjective: To investigate the relationship between depth of maxillopalatal arch and deviation of posterior septum. Methods: This study is based on paranasal sinus CT (PNSCT) scan in the coronal plane evaluation, and sinus paranasal scans were obtained from the database. One-hundred and fifty PNSCT scans were randomly chosen among the PNSCT scans which belong to adult (18 and older) patients. All scans were divided to three different groups. The first group constituted by those patients who had more convex deviation. The second group had those patients with either crest or spur deviations. The last group (control group) had no septum deviation. The data collected from each group were statistically compared. Exclusion criteria: CT imaging which has a chronic sinusitis, nasal cavity mass, and nasal polyps. Main outcome measures: angle and distance measures were taken on maxillopalatal arch and posterior nasal septum. Results: Strongly positive correlation between posterior septum deviation and depth of maxillopalatal arch was determined (r = 0.479, p = 0.001). Conclusion: These findings suggest that posterior septum deviations are considered as a result of increase in maxillopalatal depth. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
