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Öğe Enhancement of the glucose metabolism and the reverse cholesterol transport by a peroxisome proliferator receptor ? (PPAR?) agonist included in the fasciolosis treatment in naturally infested sheep(Ecole Nationale Veterinaire Toulouse, 2013) Yuksek, N.; Altug, N.; Denizhan, V.; Ceylan, E.; Agaoglu, Z.The purpose of this study was to investigate the effects of PPAR alpha agonist on metabolic parameters in naturally Fasciola-infected sheep. Twenty sheep with fasciolosis were allotted in 2 equal groups according to the received treatment (triclabendazole/levamisole in the group I and triclabendazole/levamisole + PPAR alpha agonist (2-methyl-2-phenoxy-propionic acid) in the group II) and the haematological and biochemical parameters were assessed before the treatment and 7, 14 and 28 days after and were compared to control values determined from 10 healthy sheep. As expected, fasciolosis has induced an anaemia evidenced by low haematocrit and low haemoglobinemia coupled to eosinophilia and to a moderate lymphopenia, severe liver damage characterised by hepatocyte degenerescence (significant increases in serum AST and GDH activities) and bile duct obstruction (significant increases in serum GGT activity and in serum bile acid concentrations) leading to impairement in liver metabolic functions (hypoalbuminemia, marked decreases in serum glucose concentrations and in LDL associated cholesterol concentrations). All the heamatological and biochemical alterations were at least partially alleviated by the antihelminthic treatment except the serum triglyceride concentrations which have continued to decrease during the post-treatment period and the total cholesterol and HDL associated cholesterol concentrations which have markedly increased, particularly when sheep were also treated with the PPAR alpha agonist. These results clearly demonstrated the severe metabolic liver impairment occurring during fasciolosis in sheep and the beneficial effects of the PPAR alpha agonist on the correction of the negative energy balance, particularly by promoting the reverse cholesterol transport.Öğe Enhancement of the glucose metabolism and the reverse cholesterol transport by a peroxisome proliferator receptor ? (PPARa) agonist included in the fasciolosis treatment in naturally infested sheep(2013) Yüksek, N.; Altu?, N.; Denizhan, V.; Ceylan, E.; A?ao?lu, Z.The purpose of this study was to investigate the effects of PPAR? agonist on metabolic parameters in naturally Fasciola-infected sheep. Twenty sheep with fasciolosis were allotted in 2 equal groups according to the received treatment (triclabendazole/levamisole in the group I and triclabendazole/ levamisole + PPARa agonist (2-methyl-2-phenoxy-propionic acid) in the group II) and the haematological and biochemical parameters were assessed before the treatment and 7, 14 and 28 days after and were compared to control values determined from 10 healthy sheep. As expected, fasciolosis has induced an anaemia evidenced by low haematocrit and low haemoglobinemia coupled to eosinophilia and to a moderate lymphopenia, severe liver damage characterised by hepatocyte degenerescence (significant increases in serum AST and GDH activities) and bile duct obstruction (significant increases in serum GGT activity and in serum bile acid concentrations) leading to impairement in liver metabolic functions (hypoalbuminemia, marked decreases in serum glucose concentrations and in LDL associated cholesterol concentrations). All the heamatological and biochemical alterations were at least partially alleviated by the antihelminthic treatment except the serum triglyceride concentrations which have continued to decrease during the post-treatment period and the total cholesterol and HDL associated cholesterol concentrations which have markedly increased, particularly when sheep were also treated with the PPARa agonist. These results clearly demonstrated the severe metabolic liver impairment occurring during fasciolosis in sheep and the beneficial effects of the PPARa agonist on the correction of the negative energy balance, particularly by promoting the reverse cholesterol transport.Öğe Evaluation of analgesic and antiinflammatory activity of Pimpinella anisum fixed oil extract(2006) Tas, A.; Özbek, H.; Atasoy, N.; Altug, M. Enes; Ceylan, E.In this study, fixed oil of P. anisum was investigated for anti-inflammatory activity using carrageenan-induced rat paw oedema test on the Sprague-Dawley rats and analgesic activity using tail-flick test on the Swiss-albino mice. Indomethacin and etodolac were treated reference drugs for the anti-inflammatory activity. Aspirin and morphine hydrochloride were treated reference drugs for the analgesic activity. The results showed that fixed oil of P. anisum has an anti-inflammatory action more than etodolac and this effect was as strong as indomethacin. P. anisum induces analgesic effect comparable to that of 100 mg/kg Aspirin and 10 mg/kg morphine at 30 th min. of the study. Analgesic effect of P. anisum was not significant at 90 th or 150 th min. of study.Öğe Serum biochemical profile and protein fractions in cattle with Theileriosis(Ecole Nationale Veterinaire Toulouse, 2014) Dede, S.; Altug, N.; Deger, Y.; Ozdal, N.; Ceylan, E.Theileriosis encountered frequently in Van region and causes huge economic losses in cattle, sheep and goats. This study was carried out to examine the serum biochemical profile and serum protein fractions, determined before and 7 days after buparvaquone treatment, in 28 cattle, diagnosed to be infected with T. annulata and in 15 healthy control animals from the same region. The ALT (alanine amino transferase) and ALP (alkaline phosphatase) activities and the concentrations of bilirubin and urea were markedly increased in sera from infected animals whereas the concentrations of glucose, minerals (Na, K and Ca), total proteins, albumin and of a-globulins and the albumin/globulin (A/G) ratios were significantly depressed compared to the controls. In addition, buparvaquone treatment succeeded in alleviating the serum biochemical anomalies. These results show that liver and kidney failures occur during theileriosis leading to a global protein deficiency and that serum biochemistry and serum protein analysis may allow biochemical evaluation of treatment.
