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Öğe Doxycycline/collagen/chondroitin sulfate delivery systems used for cartilage regeneration(Inst. Nat. Cercetare-Dezvoltare Text. Pielarie, 2020) Marin, Maria-Minodora; Albu Kaya, M?d?lina Georgiana; Ghica, Mihaela Violeta; D?nil?, Elena; Coar?, Gheorghe; Popa, L?cr?mioara; Chelaru, CiprianCartilage damage is difficult to self-heal due to an avascular microenvironment and distinct mechanical properties. These features are a challenge in designing a cartilaginous tissue with repairing effect without producing any local infections. Thus, a biodegradable scaffold in which the drug can be incorporated is preferable. Drug delivery systems based on collagen sponges have progressively become remarkable biomaterials for different medical applications. The aim of this work was to design and characterize some collagen/chondroitin sulfate supports with doxycycline for cartilage tissue regeneration. The doxycycline should prevent the development of potential infections. Collagen, chondroitin sulfate and doxycycline gels were cross-linked with different concentrations of glutaraldehyde and then freeze-dried in order to obtain collagen matrices. The structural characteristics for the new synthesized biomaterials were firstly assessed by infrared spectroscopy (FT-IR), and scaffolds morphology was then evaluated by optical microscopy and water uptake. The enzymatic biodegradation was also performed. Also, the sponges surface properties were quantified through contact angle. The in vitro doxycycline kinetics release was performed with a dissolution equipment and the release mechanism was investigated. The obtained results recommend these new scaffolds based on doxycycline/collagen/chondroitin sulfate as a promising approach for the treatment of cartilage problems. © 2020 Toate drepturile asupra acestei edi?ii sunt rezervate editorilor.Öğe Formulation and Characterization of Niacinamide and Collagen Emulsion and Its Investigation as a Potential Cosmeceutical Product(Mdpi, 2024) Danila, Elena; Kaya, Durmus Alpaslan; Anuta, Valentina; Popa, Lacramioara; Coman, Alina Elena; Chelaru, Ciprian; Constantinescu, Rodica RoxanaCosmeceuticals are one of the fast-growing areas of the natural personal care industry. Cosmeceuticals are cosmetic products with medicinal or drug-like benefits that can affect the biological functioning of the skin depending on the ingredients in the composition. The development of one formulation acting on the dermis and stimulating the collagen production is very important for the hydration of the skin. The association of collagen with other ingredients can have a positive effect on increasing the natural production of collagen in the skin. An example of such an ingredient is niacinamide, which, having a recognized nutritional value, has been quite recently studied. Considering these aspects, this study focused on developing oil-in-water (O/W) emulsions, based on natural ingredients (vegetable oils, floral waters, and essential oils) and hydrolyzed collagen and niacinamide as active ingredients, and on evaluating the stability, pH, optical, superficial, rheological and textural properties, as well as microbiological tests of the emulsions, in order to investigate their potential as a cosmeceutical product. All the obtained emulsions proved to be stable at variable temperatures and had a pH value compatible with natural pH of the skin, allowing their safe application. Over goniometric analysis, a partial wetting and a hydrophilic character of the emulsions were emphasized. Following the rheological analyses, all dermatocosmetic emulsions exhibited non-Newtonian pseudoplastic behavior and a thixotropic character, these properties being very important for their production process and their application on the skin surface to generate an optimal therapeutic effect. The textural characteristics recorded for all emulsions indicated adequate spreadability at the application site. All tested samples respected the Pharmacopoeia limits of microbiological contamination. All prepared emulsions have good stability, are safe for the skin and have appropriate physicochemical and microbiological characteristics; therefore, they can be used as a cosmeceutical product.Öğe HAIR MASKS BASED ON KERATIN AND COLLAGEN(Inst. Nat. Cercetare-Dezvoltare Text. Pielarie, 2022) Albu-Kaya, M?d?lina Georgiana; Ghica, Mihaela-Violeta; Dinu-Pîrvu, Cristina-Elena; Popa, L?cr?mioara; D?nil?, Elena; Chelaru, Ciprian; Anu?a, ValentinaThe study aimed to develop and characterize some O/W emulsions, designed as nourishing hair masks. The cosmetic formulations based on collagen hydrolysate, keratin, and natural ingredients (essential and vegetable oils) were organoleptically evaluated. The pH, morphological, superficial, and rheological properties were assessed as a physicochemical background. The rheological measurements were performed at 23 and 32°C, and the shear stress versus shear rate ascending and descending rheograms were built, together with the flow profiles of viscosity as a function of shear rate. The cosmetic emulsions were stable at temperature variation and the pH values were considered physiologically acceptable for the skin, indicating that formulations can be safely applied for cosmetic purposes. Results from the optical microscopy analysis showed that all emulsions presented a creamy and non-greasy appearance. The superficial profiles, quantified through contact angle at solid/liquid interface, were specific for hydrophilic formulations. The emulsions showed pseudoplastic and thixotropic behavior, facilitating the formulations’ flow and the topical application. The Power law model was used to quantify the flow properties, and the thixotropic analysis was conducted using particular descriptors, namely thixotropic area, and thixotropic index. The designed emulsions presented appropriate physicochemical properties for cosmetic applications in hair care. © 2022 Toate drepturile asupra acestei edi?ii sunt rezervate editorilor.
