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Phthalates in commonly used pharmaceuticals
(Taylor & Francis Inc, 2023) Sungur, Sana; Ciran, Mutasim; Koroglu, Muaz; Turgut, F. Hilmi
Phthalates are man-made, endocrine disrupting chemicals that are commonly used in plastics, medical applications, drugs, personal care products, cosmetics, perfumes, home furnishings, dyes, children's toys, food packaging. Animal studies have revealed that phthalates have many adverse health effects. Since phthalates do not dissolve in acidic environments, they are only soluble in neutral or basic environments, they are frequently used in gastro-resistant film coatings of drugs that are not intended to dissolve in the stomach and that need to be dissolved directly in the intestine. Within the scope of this study, phthalates and their amounts in frequently used drugs in our country were determined by GC-MS and the potential health risks of patients using such drugs were evaluated. It was determined that the total phthalate concentrations in the examined drug samples ranged between 0.209 and 4.800 mg kg(-1), and the amounts in a single tablet ranged between 2.7x 10(-5) and 1.5x 10(-3 )mg/tablet. The highest concentrations of total phthalate were found in cholesterol (4.800 mg kg(-1)) and blood pressure lowering drugs (4.442 mg kg(-1)). The calculated hazard index values were found to be less than one. This showed that the phthalates detected in the drugs examined did not pose a risk to human health.