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  • Küçük Resim
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    Is there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension?
    (Springer, 2015) Bayramoglu, Aysegul; Urhan Kucuk, Meral; Guler, Halil Ibrahim; Abaci, Okay; Kucukkaya, Yunus; Colak, Ertugrul
    The current study was conducted to determine whether there is a relation between hypertension and two different polymorphisms, including C1562T of the Matrix metalloproteinase-9 (MMP-9) gene and C677T of the methylenetetrahydrofolate reductase (MTHFR) gene. Genomic DNA obtained from 224 persons (125 patients with hypertension and 99 healthy controls) were used in the study. Polymorphisms were determined by using polymerase chain reaction-restriction fragment length polymorphism and electrophoresis. The results were statistically analyzed and were found to be statistically significant. The frequencies of the C1562T genotypes were found to be, in controls CC 75.8 % and CT 24.2 % and in patients CC 71.2 %, and CT 28.8 %. The frequencies of C677T genotype were found to be, in controls CC 56.6 %, CT 38.4 and TT 5.1 % in controls and in patients CC 52 %, CT 30.4 % and TT 17.6 %. In conclusion, we may suggest that there is no relation between the essential hypertension and C1562T polymorphism of MMP-9 gene; on the other hand C677T polymorphism (genotype TT) of MTHFR gene can be regarded as a genetic indicator for the development of essential hypertension.
  • Küçük Resim
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    Our Midterm Outcomes of Strabismus Surgery in Vertical Deviations
    (2020) Gürsoy, Haluk Hüseyin; Cakmak, Ayse Idil; Özalp, Onur; Ozdemir, Omur Can; Colak, Ertugrul
    The evaluation of cases operated for vertical deviation. Materials and Methods: Cases operated between January 2015and June 2016 and followed-up for at least 1 year were evaluated. Pre and postoperative angle of deviations (PD), inferior obliquemuscle (IO) functions, refractive errors, etiologies and surgeries performed were noted. Success was defined as alignment with 10PD of orthophoria and/or inferior oblique overaction (IOOA) ?+1 at the final examination. 32 out of 172 cases, surgery due tovertical deviation was performed. Primary IOOA cases (group 1; n=19; 15 was associated with esotropia, 4 with exotropia) werecompared with cases (group 2; n=13) due to other etiologies [3 Duane retraction syndrome (DRS) type 3, 4 fourth nerve palsy, 4dissociated vertical deviation (DVD), and double elevator palsy (DEP)]. IO recession was performed in all primary IOOA andfourth nerve palsy. Y-split and lateral rectus recession was performed in DRS, superior rectus recession in DVD, and inferior rectusrecession in DEP. Right spherical equivalent (SE) (D) was 1.5 (0.75-2.5) in group 1 and 0.5 (-0.625-0.875) in group 2 (p=0.014).Left SE (D) was 1.5 (0.75-2.5) in group 1 and 0.5 (0.125-1) in group 2 (p=0.024). IOOA decreased from 3.16±0.60 to 0.89±0.81postoperatively in group 1 cases (p<0.01). The upshoot regressed in 3 DRS type 3 cases postoperatively. Successful outcome wasobtained in 16 cases in group 1 (84%) and 11 cases in group 2 (84%). Satisfactory outcome is possible by case-by-case approach invarious vertical deviations.