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    Changes in retinal vessels related to varicocele: a pilot investigation
    (Wiley, 2016) Coskun, M.; Ilhan, N.; Elbeyli, A.; Rifaioglu, M. M.; Inci, M.; Davran, R.; Tuzcu, E. A.
    The aim of this study was to investigate whether retinal vasculature changes had occurred (retinal artery diameter, retinal vein diameter and artery/vein ratio) in patients with varicocele. This pilot study included 50 healthy subjects with any eye disease apart from slight refractive errors and 55 patients with varicocele. Retinal arteriolar and venular diameters were measured and summarised as central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE). Retinal microvascular diameters and the arteriolar-to-venular ratio (AVR) were assessed with a digital retinal camera. All measurements and calculations were performed using a computer-based program. The mean CRAE value was 151.8 +/- 3.6m in the study group and 150.4 +/- 4.5m in the control group. Mean CRVE value was 209.4 +/- 5.9m in the study group and 200.1 +/- 8.7m in the control group. AVR was found 0.72 +/- 0.02 in the study group and 0.75 +/- 0.03 in the control group. There were significant differences between groups in terms of CRVE and AVR. There were no significant differences between groups in terms of CRAE. The results of this study showed that the patients with varicocele showed significant changes on retinal vascular diameter.
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    GENOMIC DAMAGE IN PATIENTS WITH TYPE-2 DIABETES MELLITUS
    (Medecine Et Hygiene, 2013) Binici, D. N.; Karaman, A.; Coskun, M.; Ogiu, A. Uyanik; Ucar, F.
    Genomic damage in patients with type-2 diabetes mellitus: DNA damage seems to play a role in the pathogenesis of type-2 diabetes mellitus (DM2) and its complications. Several in vitro assays have been used to measure the DNA damage. In the present study, we aimed to investigate the frequency of sister chromatid exchange (SCE) and micronuclei (MN) in DM2 patients compared with healthy controls. SCE and MN tests were carried out with the blood-cell cultures from 50 DM2 patients and 30 healthy, age- and sex-matched control subjects. The mean age of the DM2 patients was 58.12 +/- 13.39 years, with a mean duration of the diabetes of 5.40 +/- 4.32 years. The mean level of HbA1c of the DM2 patients was 8.93 +/- 2.56. Patients with DM2 showed a higher frequency of SCE compared with controls (7.11 +/- 1.14 and 4.96 +/- 0.92, p<0.001). Furthermore, the SCE frequency was positively correlated with the plasma HbA1c level (p< 0.05), but there was no significant correlation between the duration of diabetes and SCE. On the other hand, our result showed a MN frequency significant increase in DM2 patients (3.45 +/- 1.01 per 1000 cells) relative to that of the control group (1.79 +/- 0.67 per 1000 cells) (p<0.001), but there was no significant correlation between the duration of diabetes, HbA1c and MN. In conclusion, these results suggest that DM2 is a condition with genomic instability characterized by an increased level of SCE and MN. Hyperglycemia-induced oxidative stress may be the underlying factor of the increased SCE and MN frequency.
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    Irreversible Horner's syndrome diagnosed by aproclonidine test due to benign thyroid nodule
    (Professional Medical Publications, 2013) Coskun, M.; Aydogan, A.; Gokce, C.; Ilhan, O.; Ozkan, O., V; Gokce, H.; Oksuz, H.
    We are reporting an irreversible Horner Syndrome (HS) in a patient with benign thyroid gland nodule in which thyroidectomy was performed for treatment. A 37-year-old female was admitted to our clinic with a swelling in the left lobe of the thyroid gland and ptosis at the left eyelid. The clinical diagnosis of HS was confirmed pharmacologically by aproclonidine. Histopathologic examination of thyroidectomy specimen was reported as benign nodule. To the best of our knowledge, this is a very rare report in terms of thyroid benign nodule associated with irreversible HS due to cervical sympathetic chain compression.