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  • Küçük Resim
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    Cell proliferation and apoptosis in canine oral papillomatosis
    (Urmia Univ, 2024) Karakurt, Emin; Coskun, Nuvit; Aydin, Ugur; Dag, Serpil; Beytut, Enver; Ataseven, Veysel Soydal; Yilmaz, Volkan
    This study was aimed at the evaluation of cell proliferation, p53 level and apoptotic index by immunohistochemical methods in canine oral papillomatosis. The study material comprised of tumor tissue samples taken from six dogs being admitted to the Pathology Department of Faculty of Veterinary Medicine, Kafkas University, Kars, Turkiye. Choice of immunohistochemical staining was avidin-biotin peroxidase method. Cases of canine oral papillomatosis, determined to have been caused by canine papillomavirus-1, were found to have a rather high cell proliferation index. Furthermore, all cases were immunohistochemically demonstrated to carry a mutant p53 gene. Despite the mutation of p53 gene, the shift in the Bax/Bcl-2 ratio of dogs diagnosed with tumor was in favor of the pro-apoptotic Bax gene. The apoptotic mechanism was determined to occur through both the caspasedependent and caspase-independent pathways. While the lesions occupied the entire oral cavity in some cases, histopathologically, malignant transformation was not detected in any of the six cases.
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    Endless variety for bovine virus diarrhea viruses: new members of a novel subgroup into Pestivirus A from Turkey
    (Springer, 2019) Oguzoglu, Tuba Cigdem; Koc, Bahattin Taylan; Coskun, Nuvit; Dogan, Firat; Duran-Yelken, Selda
    As ubiquitous pathogens, bovine virus diarrhea viruses (BVDVs) in cattle have been reported several times in Turkey. Over time, the frequency and importance of this infection has increased for the livestock industries. A total of 1291 animals were sampled from a dairy herd in Turkey suspected of BVDV clinical signs, for instance, reproductive failures (abortion, congenital malformations in calves, repeat breeding, etc.) and interdigital phlegmon in adult animals. Reverse transcription polymerase chain reactions (RT-PCRs) were made by using targeted 5' untranslated region (UTR), E2, and NS2-3 pestiviral gene region primers for antigen ELISA-positive samples (n = 20). The obtained amplicons were sequenced. Sequence results showed the presence of a new subgroup in Pe.stivirus A species. This paper describes the nucleotide sequences of a new BVDV 1 (BVDV 1v) subgroup member.
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    Öğe
    Molecular detection of Papillomavirus and immunohistochemical investigation of p53 gene expressions in bovine papillomas and fibropapillomas (vol 204, 278, 2022)
    (Springer, 2022) Karakurt, Emin; Coskun, Nuvit; Dag, Serpil; Beytut, Enver; Ataseven, Veysel Soydal; Yilmaz, Volkan; Dogan, Firat
    [Abstract Not Available]