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Öğe Detection of cutaneous leishmaniasis cases in Hatay and surrounding areas(2006) Culha, Gülnaz; Akçali, CenkLeishmaniasis; is a disease that is transmitted by infected sand flies when they suck the blood of mammals. Cutaneous leishmaniasis (CL), which is given such names as the Antep boil in Turkey, is mostly seen on the skin and sometimes on the mucosa and heals with a recessed scar. Between June 2003 and October 2005, 55 patients with skin lesions presented at the parasitology laboratory of the Mustafa Kemal University Medical Faculty for the detection of CL. Microscopic examination showed Leishmania amastigotes in 40 patients who were given a diagnosis of CL. Thirteen patients were men (32.5%) and 27, women (67.5%). The most frequent age range was 0-20 (57.0%). The lesions were mostly found on the face in 27 (67.5%) patients and on the hands and feet in 13 (32.5%). Fourteen patients (35.0%) had 2 or more lesions. The duration of the lesions was from a minimum of 1 month to a maximum of 3 years. The patients were mostly from Iskenderun/Kirikhan, Iskenderun/Arsus Serinyol, Altinözü, Samanda? Antakya, Harbiye and they were farmers. Cutaneous leishmaniasis was more often detected during the May-June period. Some patients came to our laboratory from regions that had not reported CL before. Therefore, we think that CL has been increasing in Hatay and its surroundings.Öğe The distribution of patients with intestinal parasites presenting at the parasitology laboratory of the Mustafa Kemal University medical faculty(2006) Culha, GülnazIn this study, fecal specimens of 3,679 patients presenting at the parasitology laboratory of the Medical Faculty of the Mustafa Kemal University between September and May 2005 were examined for intestinal parasites. A total 3,679 stool specimens from 1,260 (34.3%) males and 2,419 (65.7%) females for intestinal parasites using the native-Lugol method were examined. Intestinal parasites were found in 265 (34.23%) male and 509 (65.76%) females. One or more intestinal parasites were detected in 774 (21.03%) patients. A total of 1,720 cellophane tape specimens were examined (64 (38.60%) male and 1,056 (61.39% female). E. vermicularis was found in a total of 150 (8.72%) patients; of whom 65 (9.78%) were male patients and 85 (8.04%) female. The distribution of intestinal parasites detected in stool specimens were follows: (31.5%) Giardia intestinalis, (25.3%) Blastocystis hominis, (18.30%) Entamoeba coli, (13.40%) Entamoeba histolytica/dispar, (1.2%) Dicrocoelium dentriticum, (%1) Ascaris lumbricoides, (%2. 8) Iodamoeba bütschlii, (%1.20) Chilomastix mesnili, (1.4%) Hymenolepis nana, (1.8%) Trichomonas hominis, (0.2%) Strongyloides stercoralis and (0.7%) Taenia saginata.Öğe Falciparum malaria originating in foreign country: four cases(2007) Onlen, Yusuf; Culha, Gülnaz; Ocak, Sabahattin; Savaş, Lütfü; Güllü, MuratMalaria has been commonly determined in tropical and subtropical regions and the Plasmadium (P.) vivax generally occurs in our country, Turkey. However, in the people who have been travelling abroad from Turkey P. falciparum and P. malaria were also detected. The diagnosis was confirmed by microscopy of Giemsa stained thin and thick blood slides in four cases, at a magnification of 1000. The diagnosis of four cases was made by seeing the gametocytes of P.falciparum in thin blood films. The cases were found in Hatay region and the patients are those working abroad. The cases are presented in order to emphasize on the necessity of giving education on public health and taking the precautions for the prevention of the disease and in order to draw attention to malaria diseases caused by different species from abroad and to the fact that it can be seen in local cases as well.Öğe Investigation of the prevalence of Trichomonas vaginalis in women with complaints of vaginal discharge and itching(2006) Culha, Gülnaz; Hakverdi, Ali Ulvi; Zetero?lu, Sahin; Duran, NizamTrichomonas vaginalis (T. vaginalis) is the most common pathogen that is sexually spread in women. In this study, the presence of Trichomonas vaginalis was investigated in patients with vaginal discharge and itching who presented at the polyclinic of the Mustafa Kemal University Medical Faculty Department of Gynecology. These women were between 20-40 years of age. During gynecologic examination of patients, vaginal fluid samples were collected with swaps from the speculum and fornics to two tubes that contained sterile saline. One of the vaginal discharges collected with swaps was used for direct microscopic examination and Giemsa staining. The other one was used for culturing for T. vaginalis in Trichomonas medium that contained horse serum and antibiotics. While the fre-quency of T. vaginalis was found to be 1.81% (5 of the 275 samples) by the direct microscopic examination and Giemsa stain, this ratio was 2.18% (6 of the 275 samples) by the culture method. In conclusion, it was decided to use the culture method in diagnosis of T. vaginalis in addition to direct microscopic examination. This was the first study of T. vaginalis infection in our region and it was compared with other studies carried out in other regions of Turkey. Our results were somewhat lower than those in other regions.Öğe Leishmaniasis in Turkey: Determination of Leishmania species by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS)(Tehran University of Medical Sciences (TUMS), 2014) Culha, Gülnaz; Akyar, Isin; Yildiz Zeyrek, Fadile; Kurt, Özgür; Gündüz, Cumhur; Özensoy Töz, Seray; Östan, IpekBackground: Cutaneous leishmaniasis (CL) is endemic in Southeastern Anatolia, mainly in Sanliurfa and Hatay provinces, and the causative agents are mostly Leishmania tropica and less frequently L. infantum. Here, we report the first MALDI-TOF analyses of Leishmania promastigotes obtained from the cultures of two CL cases from Osmaniye and Hatay provinces who were initially diagnosed by microscopy, culture and identified as L. infantum with Real-Time PCR (RT-PCR). Methods: Samples obtained from the skin lesions of patients were initially stained with Giemsa and cultivated in NNN medium. Examination of the smears and cultures revealed Leishmania amastigotes and promastigotes, respectively. The promastigotes (MHOM/TR/2012/CBU15 and MHOM/TR/2012/MK05) obtained from the cultures of both patients were used for RT-PCR targeting the ITS-1 region in the SSU of rRNA. The reference strains of four Leishmania species (L. infantum, L. donovani, L. tropica and L. major) were initially assessed with MALDI-TOF and their data were added to MALDI-TOF Biotyper Library. Results: Both RT-PCR and MALDI-TOF analyses indicated that the causative agent in both patient samples was L. infantum. Conclusion: Despite disadvantages such as requirement of culture fluid with nothing but promastigotes and high cost, MALDI-TOF analysis may be a fast, sensitive and specific diagnostic tool in especially large-scale research studies, where the cost declines, relatively.Öğe Problem of cystic echinococcoss in Hatay(2008) Hakverdi, Sibel; Culha, Gülnaz; Canda, M Serefettin; Yaldiz, Mehmet; Altintaş, SüleymanEchinococcosis is a zoonotic infection caused by Echinococcus granulosus and E. multilocularis. It continues to be a serious public health problem in many countries including Turkey. In Hatay, no previous study has been carried out; therefore, in this study, in order to determine its prevalence and to attract scientific attention to this issue, we have retrospectively evaluated cases of cystic echinococcosis in human patients presenting at the pathology laboratory of the Mustafa Kemal University, Faculty of Medicine, Research Hospital, as well as Antakya and Iskenderun State Hospitals. We have identified a total of 26 cases, of which 18 were in female patients (69.23%) and 8 in male patients (30.76%). The highest rate of cystic echinococcosis was found in the liver (57.6%), and lungs (19.23%). It was also found in the peritoneal region, spleen, cervical region, muscle, and an incision scar. In addition, the presence of cystic echinococcosis was investigated in 35,812 cattle slaughtered in Antakya slaughterhouse and 5,448 (3.23%) were found to have cystic echinococcosis.Öğe Strongyloides stercoralis in a patient complaining of chronic diarrhea(2006) Culha, Gülnaz; Savaş, Lütfü; Onlen, YusufIn this study, a case of Strongyloides stercoralis infection in a 38-year-old patient with complaints of chronic diarrhea and stomach ache is presented. His history showed that the patient who has been a mechanic for 25 years is a farmer as well. S. stercoralis larvae were found during the parasitological examination of the patient's stool samples taken 3 times. The patient was given Albendazol (400 mg a day) for fifteen days. After the patient started to take Albendazol, there was a reduction in the number of parasites in the stool examined on the fifth day. In the stool examinations made on the tenth day, fifteenth day and after the treatment ended, no parasites were seen. When the treatment was completed, all the complaints of the patient disappeared. It was found that no investigation of parasitic infection had been made previously and he had been given different treatments. For this reason, it is important to investigate the possibility of parasitic infection in patients with chronic diarrhea.
