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    Apoptosisinbovineocularsquamousecellcarcinomas
    (2022) Kutlu, Tuncer; Karakurt, Emin; Aydın, Uğur; Beytut, Enver; Özaydın, İsa; Dağ, Serpil; Aksoy, Özgür
    Aim: Cell death, especially apoptosis, is one of the most studied topics regarding cells. Understanding the mechanism of apoptosis in\rdiseases will help understand the pathogenesis of diseases, as well\ras the treatment. This study aims to grade the Bovine ocular squamous cell carcinoma (BOSCC) and to evaluate apoptosis in tumors\rwith different anaplastic features.\rMaterials and Methods: A total of 30 formalin-fixed tumor tissues\rconsisting of 10 poorly-differentiated, 10 moderately-differentiated,\rand 10 well-differentiated tissues were used to examine apoptosis in\rBOSCCs. Hematoxylin & eosin (HE) was performed for histopathological examination and TUNEL staining was performed for detection\rof apoptosis in all BOSCCs.\rResults: It was determined that apoptosis decreased as the malignancy increased in BOSCCs (p<0.001). Although all the tumors\rexamined were malignant, apoptosis, i.e. controlled cell death, was\rfound to be severe in well-differentiated type and mild in moderate\rand poorly-differentiated types.\rConclusion: It was concluded that this case observed in bovines\rshould be considered in studies on the pathogenesis of cancer and\rtreatment.