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    Effect of phosphodiesterase-5 inhibitor on hearing
    (Cambridge Univ Press, 2009) Okuyucu, S.; Guven, O. E.; Akoglu, E.; Ucar, E.; Dagli, S.
    Objective: Following a report of sudden hearing loss in a patient taking phosphodiesterase type 5 inhibitor, and a Food and Drug Administration announcement concerning this class of drugs, a study was planned to investigate if ototoxicity occurs in patients using phosphodiesterase 5 inhibitor for erectile dysfunction. Methods: Eighteen patients with erectile dysfunction who had been using phosphodiesterase 5 inhibitor were included in the study. Audiometric tests were performed on all patients, between the frequencies 250 and 16 000 Hz, before and 1, 5 and 72 hours after drug ingestion. Results: Four patients showed a unilateral threshold decrease compatible with ototoxicity criteria; this change was reversible. A statistically significant difference in pre- versus post-drug hearing thresholds was observed in the right ear at 10 000 Hz (p = 0.008). There were no statistically significant hearing threshold differences at any other frequencies (p > 0.05). Conclusion: Although temporary ototoxicity was noted in four patients, we could not find any permanent, deleterious effect of phosphodiesterase type 5 inhibitor on hearing thresholds.
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    Hearing loss in patients with Behcet's disease: an audiological and transient evoked otoacoustic emission study
    (Cambridge Univ Press, 2010) Aslan, S.; Serarslan, G.; Savas, N.; Teksoz, E.; Dagli, S.
    Objective: To investigate hearing loss in patients with Behcet's disease. Materials and methods: Twenty-four consecutive cases ofBehqet's disease and 24 sex- and age-inatched controls were included in this study. Pure tone and high frequency audiometric tests were performed and pure tone average hearing thresholds calculated for both groups. Transient evoked otoacoustic emission testing was also performed. Results: Pure tone audiometry showed a sensorineural hearing loss in 15 of the Behcet's disease cars. Hearing thresholds were significantly higher in the study group than in the control group, on both pure tone frequency (except 0.5 kHz) and high frequency audiometry. Significant reductions in transient evoked otoacoustic emission amplitude were found at 1.4 and 2 kHz in the Behcet's disease patients. There were no significant differences in reproducibility, stimulus intensity or stability, comparing the Behcet's disease patients and controls. Conclusion: Significantly lower mid-frequency amplitudes were found in Behcet's patients on transient evoked otoacoustic emission testing.
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    Large maxillary ameloblastoma: a case report
    (Galenos Yayincilik, 2009) Beriat, G. K.; Ezerarslan, H.; Dagli, S.; Kulacoglu, S.
    Ameloblastoma is a rare epithelial tumor of odontogenic origin. Ameloblastoma is mostly encountered in the mandible but it is rarely seen in maxilla. It may reveal difficulties in distinguishing other odontogenic and non-odontogenic jaw tumours because it can mimic symptoms and diagnosis of these. Although it is considered as a benign disease it can grow very rapidly and infiltrate the surrounding tissues. The lesions in the maxilla tend to be more extensive and invasive than those in the mandible because of the lesser amount of dense cortical bone. This case report presents one of the large maxillary ameloblastomas with an extention to periorbital tissues, infratemporal fossa, paranasal sinuses, hard palate and premaxillary subcutaneous tissue.